Mouse macrophage

They encapsulated poly(MA-CDA) into mannan-coated liposomes and evaluated superoxide production from mouse macrophages. The activity was three- to five-fold high compared with uncapsulated poly(MA-CDA) itself [5,11], suggesting that an increased incorporation of the polymer by the receptor-mediated endocytosis mediated the higher biological activity.. 

Scarei S., Giovine M., Gasparini A., Damonte G., Millo E., Pozzolini M., Benatti U. Modified peptide nucleic acids are internalized in mouse macrophages RAW 264.7 and inhibit inducible nitric oxide synthase. FEB. S. Lett. 1999 451 264-268. 

Preventing immunological hepatocyte damage Inhibitors of NO generation in mouse macrophage cells Antiplasmoidal activity... 

Goodlick, L.A. and Kane, A.B. (1986). Role of reactive oxygen metabolites in crocidolite asbestos toxicity to mouse macrophages. Cancer Res. 46, 5558-5566. 

Hong CH, Sun KH, Jin O, Sun SK, Kyung AN, Sang KL. Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells. J Ethnopharmacol 2002 83 153-159. 

Rafi, MM and Shafaie, Y, 2007. Dietary lutein modulates inducible nitric oxide synthase (iNOS) gene and protein expression in mouse macrophage cells (RAW 264.7). Mol Nutr Food Res 51, 333-340. 

Sakata K, Hirose Y, Qiao Z, Tanaka T and Mori H. 2003. Inhibition of inducible isoforms of cyclooxygenase and nitric oxide synthase by flavonoid hesperidin in mouse macrophage cell line. Cancer Lett 199(2)439-145. 

High antioxidative activity carvedilol has been shown in isolated rat heart mitochondria [297] and in the protection against myocardial injury in postischemic rat hearts [281]. Carvedilol also preserved tissue GSL content and diminished peroxynitrite-induced tissue injury in hypercholesterolemic rabbits [298]. Habon et al. [299] showed that carvedilol significantly decreased the ischemia-reperfusion-stimulated free radical formation and lipid peroxidation in rat hearts. Very small I50 values have been obtained for the metabolite of carvedilol SB 211475 in the iron-ascorbate-initiated lipid peroxidation of brain homogenate (0.28 pmol D1), mouse macrophage-stimulated LDL oxidation (0.043 pmol I 1), the hydroxyl-initiated lipid peroxidation of bovine pulmonary artery endothelial cells (0.15 pmol U1), the cell damage measured by LDL release (0.16 pmol l-1), and the promotion of cell survival (0.13 pmol l-1) [300]. SB 211475 also inhibited superoxide production by PMA-stimulated human neutrophils. 

Leenen, P.J. et al., Markers of mouse macrophage development detected by monoclonal antibodies, J. Immunol. Methods, 174, 15, 1994. 

Holness, C.L. et al., Macrosialin, a mouse macrophage-restricted glycoprotein, is a member of the lamp/lgp family, J. Biol. Chem., 268, 9661, 1993. 

Few studies have been conducted to date evaluating the effects of Pb exposure on host resistance to parasitic diseases, although one study examined the effect of Pb on the ability of mouse macrophages to kill Leishmania enriettii parasites in vitro [87], The authors found that 30-100 pM Pb acetate interfered with the killing ability of macrophages without producing macrophage cytotoxicity. 

Mercuric chloride can reduce the superoxide anion production by mouse macrophages [ 174], but this effect is probably of little toxicological significance in view of the high concentrations required and of its reversibilities. The effect has been suggested to result from loss of the reducing properties of cellular NADPH. 

Kwon, Nathan and Stuehr37 found tetrahydrofolic acid (BH4) to serve as a cofactor for the production of NO from mouse macrophages. This compound had been established... 

Ramprasad, M.P., Fischer, W., Witztum, J.L., Sambrano, G.R., Quehenberger, O., and Steinberg, D., 1995, The 94- to 97-kDa mouse macrophage membrane protein that recognizes oxidized low density lipoprotein and phosphatidylserine-rich liposomes is identical to macrosiaUn, the mouse homologue of human CD68, Proc. Natl. Acad. Sci. U.S.A. 92 9580-9584. 

Merck s L-651,896 (54) was the lead compound from a series of dihydro-benzofuranols [158]. L-651,896 inhibited cRBL (1 //M) as well as platelet 12-LO (5.9 /zM). In zymosan-stimulated mouse macrophages, both LTC4 and PGE2 release were inhibited (0.1 //M and 1.1 //M, respectively) similar potency was seen in rat and human ISN. Potent topical activity in AAE was seen, with LT production and oedema both inhibited at 20-30 nM/ear. LT levels were also reduced in mouse oxazolone contact sensitivity, but in this... 

Other compounds containing heteroatom-heteroatom bonds have been reported as 5-LO inhibitors. Diphenyldisulphides and substituted analogues, as well as disulphiram (108), inhibited cRBL and LT release from zymosan-stimulated mouse macrophages (0.3-20 / M) [277, 278]. A number of thiosulphinate esters such as (109) and related compounds, isolated from onion and garlic, were likewise active in cells and cell-free enzymes over the... 

The unsubstituted 1-naphthyl compound Wy-47,288 (144) was inactive orally, but showed topical activity in several models (AAE, phorbol ester ear oedema, oxazolone-induced contact sensitivity, and UV erythema) [351]. In rat neutrophils, Wy-47,288 showed selectivity for 5-LO over CO (0.4 and 6.3 /iM, respectively), and was even more selective in mouse macrophages. 

Beauveriolides I (19) and III (20), two fungal (Beauveria Spp) metabolites, have been found to be specific inhibitors of lipid droplet formation in mouse macrophages. It has been recently observed that the metabolisms of A[3 proteins and cholesterol esters are closely linked. One of the... 

Liang, Y.C. et ah. Suppression of inducible cyclooxygenase and nitric oxide synthase through activation of peroxisome proliferator-activated receptor-y by flavonoids in mouse macrophages, FEBS Lett., 496, 12, 2001. 

---