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Enzymes enzyme inhibitor

Many drugs are effective as a result of inhibiting one or more enzymes. Enzyme inhibitors reduce the rate of formation of product. In a closed system such as an enzyme assay in a test tube, they do not alter the amount of product that is ultimately generated rather, it takes longer in the presence of an inhibitor to generate a given amount of product. [Pg.113]

Many substances can affect metabolic processes by influencing the activity of enzymes. Enzyme inhibitors are particularly important here. A large proportion of medicines act as enzyme inhibitors. Enzyme-kinetic experiments are therefore an important aspect of drug development and testing procedures. Natural metabolites are also involved in regulatory processes as inhibitors (see p.ll4). [Pg.96]

Phage display techniques can be used in any field where molecular biological approaches find application. It can be successfully used for epitope mapping, vaccine development, identification of proteinkinase substrates and nonpeptid ligands, selection of functional interactions of hormones, enzymes, enzyme inhibitors, mapping... [Pg.119]

Y3. Yamamoto, N., Nagasawa, Y., Sawai, M., Sudo, T., andTsubomura, H., Potentiometric investigations of antigen-antibody and enzyme-enzyme inhibitor reactions using chemically modified metal electrodes. J. Immunol. Methods 22, 309-317 (1978). [Pg.110]

Serum contains more than 100 different proteins, each under separate genetic control. They are transport proteins for hormones, vitamins, lipids, metals, pigments, and drugs enzymes enzyme inhibitors (proteinase inhibitors) hormones antibodies clotting factors complement components and kinin precursors. Quantitation (by radial immunodiffusion, electroimmunoassay, nephelometric methods, enzyme-linked immunological methods, and radioimmunoassay) of the various constituents of serum is of value in diagnosing and following the course of certain diseases. Several of these proteins are discussed elsewhere in the text. [Pg.949]

Telomerase has not yet made the enzyme/enzyme inhibitor handbooks, nor the Sigma catalog Biochemicals and Reagents for Life Science Research (Sigma-Ald-rich, St. Louis, MO). However, a number of inhibitors are listed in the handbooks of enzyme inhibitors for RNA-directed DNA polymerase, including several antibiotics such as actinomydn. [Pg.184]

To further clarify and understand the unusual ligand binding and the mechanism of the reaction, additional structures of mutant enzymes, enzyme—inhibitor complexes and mutant enzyme—inhibitor complexes were studied. When a high-resolution crystal structure (1.0 A) of the enzyme—substrate complex was examined, a substrate-sized internal cavity was found behind the flaps near the product-binding site. The crystal structure (2.4 A) of the enzyme complexed with the inhibitor vanillate showed that the flaps were partly opened when compared to the product-bound enzyme. [Pg.429]

Many magnetic adsorbents have been used for the isolation of various biologically active macromolecules such as enzymes, enzyme inhibitors, DNA, RNA, antibodies, antigens, etc. from different sources such as nutrient media, fermentation broth, tissue extracts, body fluids, and others. However, the present discussion is restricted to enzymes only. [Pg.174]

Yamamoto N., Nagasawa Y., Shuto S., Sawai M., Sudo T. and Tsubomura H. (1978) The electrical method of investigation of the antigen-antibody and enzyme-enzyme inhibitor reactions using chemically modified electrodes. Chem. Letters, 245-246. [Pg.188]

Application of the CCM to small sets (n < 6) of enzyme inhibitors revealed correlations between the inhibitory activity and the chirality measure of the inhibitors, calculated by Eq. (26) for the entire structure or for the substructure that interacts with the enzyme (pharmacophore) [41], This was done for arylammonium inhibitors of trypsin, Di-dopamine receptor inhibitors, and organophosphate inhibitors of trypsin, acetylcholine esterase, and butyrylcholine esterase. Because the CCM values are equal for opposite enantiomers, the method had to be applied separately to the two families of enantiomers (R- and S-enantiomers). [Pg.419]

Bartlett P A and C K Marlowe 1987. Evaluation of Intrinsic Binding Energy from a Hydrogen-bondi Group in an Enzyme Inhibitor. Science 235 569-571. [Pg.649]

J1992. LUDI - Rule-Based Automatic Design of New Substituents for Enzyme Inhibitor Leads. mal of Computer-Aided Molecular Design 6 593-606. [Pg.736]

Kubinyi H1998. Structure-based Design of Enzyme Inhibitors and Receptor Ligands. Current Opinion i. Drug Discovery and Development 1 5-15. [Pg.739]

In the case of competitive inhibition, the equilibrium between the enzyme, E, the inhibitor, 1, and the enzyme-inhibitor complex, El, is described by the equilibrium constant Ki. [Pg.662]

Enzyme catalysis Enzyme electrode Enzyme immobilization Enzyme immunoassay Enzyme inhibitors... [Pg.364]


See other pages where Enzymes enzyme inhibitor is mentioned: [Pg.30]    [Pg.406]    [Pg.241]    [Pg.686]    [Pg.398]    [Pg.443]    [Pg.581]    [Pg.22]    [Pg.417]    [Pg.352]    [Pg.4]    [Pg.1510]    [Pg.30]    [Pg.406]    [Pg.241]    [Pg.686]    [Pg.398]    [Pg.443]    [Pg.581]    [Pg.22]    [Pg.417]    [Pg.352]    [Pg.4]    [Pg.1510]    [Pg.133]    [Pg.326]    [Pg.711]    [Pg.639]    [Pg.662]    [Pg.15]    [Pg.23]    [Pg.55]    [Pg.55]    [Pg.60]    [Pg.65]    [Pg.65]    [Pg.204]    [Pg.241]    [Pg.346]    [Pg.440]    [Pg.591]    [Pg.682]    [Pg.686]    [Pg.747]    [Pg.750]   


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Acrylate enzyme inhibitor

Active-site-directed enzyme inhibitors

Allosteric enzymes, inhibitor activator effect

Aminoglycoside-modifying Enzyme Inhibitors Targeting Ribosomal RNA

Angioedema angiotensin-converting enzyme inhibitor

Angioedema enzyme inhibitors

Angiotensin I converting enzyme (ACE inhibitors

Angiotensin converting enzyme dual inhibitors

Angiotensin converting enzyme inhibitors (ACE

Angiotensin converting enzyme inhibitors actions

Angiotensin converting enzyme inhibitors effects

Angiotensin converting enzyme inhibitors heart failure management

Angiotensin converting enzyme inhibitors hypertensive renal disease

Angiotensin converting enzyme inhibitors prevention

Angiotensin converting enzyme inhibitors specific agents

Angiotensin converting enzyme inhibitors transporters

Angiotensin-converting enzyme (ACE) inhibitors for hypertension

Angiotensin-converting enzyme inhibitor

Angiotensin-converting enzyme inhibitor development

Angiotensin-converting enzyme inhibitors NSAIDs

Angiotensin-converting enzyme inhibitors adverse effects

Angiotensin-converting enzyme inhibitors adverse interactions

Angiotensin-converting enzyme inhibitors and hypertension

Angiotensin-converting enzyme inhibitors angioedema with

Angiotensin-converting enzyme inhibitors availability

Angiotensin-converting enzyme inhibitors binding

Angiotensin-converting enzyme inhibitors bradykinin

Angiotensin-converting enzyme inhibitors captopril

Angiotensin-converting enzyme inhibitors clearance

Angiotensin-converting enzyme inhibitors concepts

Angiotensin-converting enzyme inhibitors congestive heart failure

Angiotensin-converting enzyme inhibitors contraindications

Angiotensin-converting enzyme inhibitors contributions

Angiotensin-converting enzyme inhibitors coronary heart disease

Angiotensin-converting enzyme inhibitors cough with

Angiotensin-converting enzyme inhibitors diabetic nephropathy treatment

Angiotensin-converting enzyme inhibitors dosing

Angiotensin-converting enzyme inhibitors drug interactions

Angiotensin-converting enzyme inhibitors drug interactions with

Angiotensin-converting enzyme inhibitors drugs implication

Angiotensin-converting enzyme inhibitors enalapril

Angiotensin-converting enzyme inhibitors fosinopril

Angiotensin-converting enzyme inhibitors hyperkalemia with

Angiotensin-converting enzyme inhibitors hypertension treatment

Angiotensin-converting enzyme inhibitors in acute coronary syndromes

Angiotensin-converting enzyme inhibitors in heart failure

Angiotensin-converting enzyme inhibitors in hypertension

Angiotensin-converting enzyme inhibitors intravenous

Angiotensin-converting enzyme inhibitors lisinopril

Angiotensin-converting enzyme inhibitors metabolism

Angiotensin-converting enzyme inhibitors myocardial infarction

Angiotensin-converting enzyme inhibitors nephrotoxicity

Angiotensin-converting enzyme inhibitors patients

Angiotensin-converting enzyme inhibitors pharmacokinetics

Angiotensin-converting enzyme inhibitors ramipril

Angiotensin-converting enzyme inhibitors renal disease treatment

Angiotensin-converting enzyme inhibitors renal insufficiency

Angiotensin-converting enzyme inhibitors side effects

Angiotensin-converting-enzyme inhibitor ACEI)

Angiotension-converting enzyme inhibitors

Antibacterial enzyme inhibitors

Anticancer drugs enzyme inhibitors

Antifungal enzyme inhibitors

Antihypertensive drugs angiotensin-converting enzyme inhibitors

Antimetabolites competitive enzyme inhibitors

Antiprotozoal enzyme inhibitors

Antiviral enzyme inhibitors

Binding site homology, enzyme inhibitors

Biosynthesis enzyme inhibitors

Bisubstrate analog enzyme inhibitors

Bonds enzyme-inhibitor

Boronic Esters as Enzyme Inhibitors

Boronic enzyme inhibitors

Buckwheat enzymes/enzyme inhibitors

Capoten Angiotensin converting enzyme inhibitor

Captopril converting enzyme) inhibitors

Carbohydrate-processing enzymes inhibitors

Cardiovascular drugs angiotensin-converting enzyme inhibitors

Cathepsin enzyme inhibitors

Composition digestive enzyme inhibitors

Conformational change, mechanism enzyme inhibitors

Conjugate enzyme inhibitors, effect

Converting enzyme inhibitors

Cough enzyme inhibitors

Covalent bonds enzyme-inhibitor

Covalently binding enzyme inhibitors

Covalently binding enzyme inhibitors inactivation

Cysteine enzyme inhibitor

Cytochrome P450 enzymes inhibitors

Determination enzyme inhibitor

Determining Modality for Tight Binding Enzyme Inhibitors

Development of Natural Product-based Inhibitors for Enzymes Belonging to the Same Family

Dextran enzyme inhibitors, effect

Digestive enzyme, protein inhibitors

Diisopropylfluorophosphate enzyme inhibitor

Drug design/discovery enzyme inhibitors

Electrostatic interactions enzyme inhibitors

Endothelin-converting enzyme inhibitors

Energy enzyme-inhibitor complex

Enzym-inhibitor complex

Enzyme ACE inhibitor

Enzyme Kinetics and Inhibitors

Enzyme Kinetics in the Presence of an Inhibitor

Enzyme Sensors for Inhibitors

Enzyme activation inhibitors

Enzyme catalysis, activation energy inhibitor

Enzyme classical inhibitor

Enzyme immunoassays inhibitors

Enzyme inhibition polypeptide protease inhibitors

Enzyme inhibition, drug design mechanism-based inhibitors

Enzyme inhibition/inhibitors active site directed

Enzyme inhibition/inhibitors affinity

Enzyme inhibition/inhibitors anticancer

Enzyme inhibition/inhibitors antimetabolite

Enzyme inhibition/inhibitors antiretroviral

Enzyme inhibition/inhibitors competitive

Enzyme inhibition/inhibitors general concepts

Enzyme inhibition/inhibitors irreversible

Enzyme inhibition/inhibitors mechanism based

Enzyme inhibition/inhibitors noncompetitive

Enzyme inhibition/inhibitors phosphodiesterase

Enzyme inhibition/inhibitors reversible

Enzyme inhibition/inhibitors specificity

Enzyme inhibition/inhibitors transition-state analog

Enzyme inhibitor EPSP synthase

Enzyme inhibitor binding

Enzyme inhibitor chorismate mutase

Enzyme inhibitor data

Enzyme inhibitor libraries

Enzyme inhibitor pepsin

Enzyme inhibitor thermolysin

Enzyme inhibitor, occurrence

Enzyme inhibitor/inhibition

Enzyme inhibitors

Enzyme inhibitors

Enzyme inhibitors Cumulative

Enzyme inhibitors acids, based

Enzyme inhibitors active-site-directed irreversible

Enzyme inhibitors affinity labels

Enzyme inhibitors allosteric

Enzyme inhibitors antimycin

Enzyme inhibitors applications

Enzyme inhibitors arsenicals

Enzyme inhibitors as drugs

Enzyme inhibitors aspartic proteinase

Enzyme inhibitors azide

Enzyme inhibitors choline acetyltransferase

Enzyme inhibitors coadministration with drugs

Enzyme inhibitors commercial applications

Enzyme inhibitors competitive

Enzyme inhibitors cyanide

Enzyme inhibitors drug metabolism

Enzyme inhibitors fluoride

Enzyme inhibitors fluorine-containing

Enzyme inhibitors homodimers

Enzyme inhibitors human immunodeficiency virus protease

Enzyme inhibitors human leukocyte elastase

Enzyme inhibitors in foods

Enzyme inhibitors iodoacetate

Enzyme inhibitors irreversible

Enzyme inhibitors mercurials

Enzyme inhibitors oligomycin

Enzyme inhibitors ouabain

Enzyme inhibitors phosphodiesterase

Enzyme inhibitors polymers, based

Enzyme inhibitors polypeptides, based

Enzyme inhibitors pseudoirreversible

Enzyme inhibitors rapid, reversible

Enzyme inhibitors reversible

Enzyme inhibitors specific Enzymes

Enzyme inhibitors synthesis

Enzyme inhibitors thymidylate synthase

Enzyme inhibitors transition-state analogs

Enzyme inhibitors treatment

Enzyme inhibitors twin drugs

Enzyme inhibitors types

Enzyme inhibitors urokinase

Enzyme inhibitors, design

Enzyme inhibitors, effect

Enzyme inhibitors, immunosuppressive action

Enzyme inhibitors, structure-function

Enzyme inhibitors, structure-function correlation

Enzyme kinetics competitive inhibitors

Enzyme kinetics inhibitor

Enzyme mixed inhibitors

Enzyme protease inhibitor

Enzyme reactions proton inhibitors/activators

Enzyme serine protease inhibitor

Enzyme slowly binding inhibitor

Enzyme substrate/inhibitor complex

Enzyme suicide inhibitors

Enzyme thrombin inhibitor

Enzyme tight-binding inhibitor

Enzyme uncompetitive inhibitors

Enzyme-Inhibitor Binding Equilibria

Enzyme-Reaction Intermediate Analogues as Examples of Tight Binding Inhibitors

Enzyme-activated inhibitors

Enzyme-activated irreversible inhibitors

Enzyme-inhibitor association

Enzyme-inhibitor complex

Enzyme-inhibitor complex, kinetics

Enzyme-inhibitor dissociation constant reactions

Enzyme-inhibitor encounter complex

Enzyme-inhibitor interactions docking

Enzyme-linked immunosorbent inhibitors

Enzyme-linked inhibitors

Enzyme/transporter inhibitor

Enzymes inhibitor detection

Enzymes, active conformation inhibitors

Evaluation of Enzyme Inhibitors in Drug Discovery, by Robert A. Copeland

Flavonoids enzyme inhibitors

Gastrointestinal tract enzyme inhibitors

Ground-state analog enzyme inhibitors

Hemodynamically-mediated kidney injury angiotensin-converting enzyme inhibitors

Homodimers as enzyme inhibitors

Hormones as enzyme inhibitors

Human enzymes inhibitors

Hydrogen bonds enzyme inhibitors

Hydrolytic enzyme inhibitors

Hydrophobic interactions enzyme inhibitors

Hyperkalemia enzyme inhibitors

Hypoglycemia enzyme inhibitors

Immobilized enzyme inhibitors

Inactivation enzyme inhibitors

Inhibitor of enzymes

Inhibitor of proteolytic enzymes

Inhibitor-enzyme dissociation constant

Inhibitor-enzyme interactions

Inhibitors Permanently Alter the Enzyme Structure

Inhibitors enzyme activity affected

Inhibitors enzymes and

Inhibitors in study of enzyme mechanisms

Inhibitors of angiotensin-converting enzyme

Inhibitors substrate-enzyme interactions

Inhibitors, endogenous proteolytic enzymes

Inhibitors, enzyme cysteine proteinase

Inhibitors, enzyme sensors

Inhibitors, enzymes multiplicity

Inhibitors, enzymes trypsin activity

Inhibitors, proteolytic enzyme

Interferences with Urinary Glucose and Enzymes—Endogenous Inhibitors

Interleukin-1/? converting enzyme inhibitors

Iodoacetic enzyme inhibitor

Kinase Inhibitors - Stabilizing Inactive Enzyme Conformations

Kunitz enzyme inhibitors

Lipase inhibitor, enzyme inhibition

Mechanism-based enzyme inhibitor

Medicinal uses of enzyme inhibitors

Michaelis-Menten enzyme kinetics inhibitors

Microarray enzyme substrate/inhibitor

Modification of Chemical Reactivity Enzyme Inhibitors

Molecular heterogeneity, enzyme inhibitors

Multiple binding sites, enzyme inhibitors

Multisubstrate analog enzyme inhibitors

Natural enzyme inhibitors

Noncompetitive enzyme inhibitors

Noncompetitive inhibitor, enzyme kinetics

Noncovalently binding enzyme inhibitors

Oral delivery enzyme inhibitors

Organophosphorus compounds enzyme inhibitors

Other Enzyme Inhibitors

Peptic enzyme inhibitors

Pharmaceuticals enzyme inhibitors

Phosphate Transferring Enzyme Inhibitors

Plant inhibitors of digestive enzymes

Polymers polymer-enzyme inhibitor conjugates

Potato enzyme inhibitors

Prescription drugs enzyme) inhibitors

Principles of Enzyme-Inhibitor Design

Process development, inhibitor enzymes

Proteins enzyme inhibitors

RNase, enzyme-inhibitor complexes

Renal impairment enzyme inhibitors

Renin-angiotensin system enzyme inhibitors

Resistance-causing enzymes inhibitors

Retroviral enzymes inhibitor

Reversible Modes of Inhibitor Interactions with Enzymes

Ribonucleotide reductase enzyme-activated inhibitors

Secretase Enzyme Inhibitors

Sequence homology, enzyme inhibitors

Slow-binding enzyme inhibitors

Slow-tight-binding enzyme inhibitors

Specific enzyme inhibitors

Structure enzyme: coenzyme: inhibitor complex

Study Angiotensin-Converting Enzyme Inhibitors

Substrate analog enzyme inhibitors

Substrate binding enzyme:coenzyme :inhibitor complex

Substrate-enzyme-inhibitor

Sugar-nucleotide-binding enzymes inhibitors

Suicide enzyme-inactivator mechanism-based inhibitor

Tables enzyme inhibitors

Toxicants enzyme inhibitors

Trehalase inhibitors enzymes

Uncompetitive inhibitor, enzyme kinetics

Unsaturated carbapyranoses as enzyme inhibitors

Xenobiotic metabolizing enzymes inhibitors

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