Enzyme inhibitor design

De novo enzyme inhibitor design, 10 324-325 DENOX, 11 692 Denoxification, 17 788 DENOX units, 10 605 Dense medium separation (DMS),... 

Enzyme-inhibitor design, genetic software techniques for, 10 342 Enzyme inhibitor implants, 10 343 Enzyme-inhibitor interactions, visualization of, 10 340 Enzyme-inhibitor models, based on pharmacophores, 10 333 Enzyme inhibitors, 10 317-346 biological effects of, 10 328... 

Organometallics as Structural Scaffolds for Enzyme Inhibitor Design... 

The first principle of enzyme inhibitor design is Use aU the available information . This information can be biological, functional, structural, chemical, or theoretical. There is such an immense amount of biological information on thrombin that it cannot be surveyed here we focus on thrombin as a serine protease of the trypsin family and take fibrinogen to be its primary substrate. A convenient way to look at the information available is from the more general to the very specific. For thrombin, we may take four levels the general catalytic mechanism the particular substrate types processed the structure of the protein and, often forgotten, the flexibihty of the protein required to achieve this function. 

Peter A. Tipton received his undergraduate degree in chemistry from Cornell University, and his Ph.D. in biochemistry at the University of Wisconsin-Madison, where he worked with Professor W. W. Cleland on the mechanism of hiotin carboxylase. He spent a postdoctoral stint in Professor Jack Peisach s laboratory at the Albert Einstein College of Medicine, where he used pulsed EPR methods to study active-site geometries in Mn " -utilizing enzymes. He assumed a position at the University of Missouri, where he is currently professor of biochemistry. His research interests are in metabolic pathways and enzyme mechanisms in bacterial pathogens, and enzyme inhibitor design. 

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