Angiotensin-converting enzyme inhibitors clearance

ACC = American College of Cardiology ACE = angiotensin-converting enzyme Inhibitor AHA = American Heart Association AMI = acute myocardial Infarction CAD = coronary artery disease EF = ejection fraction IV = Intravenous CrcL = creatinine clearance SC = subcutaneous. 

No adverse interactions have been reported in patients treated with lithium and P-adrenoreceptor antagonists, whereas methyidopa has been reported to induce neurotoxic symptoms in some lithium-treated patients.There is a risk of lithium intoxication with simultaneous administration of angiotensin-converting enzyme inhibitors (ACEIs) lithium clearance may be reduced by up to 25%. ° Losartan, an angiotensin II antagonist, was anecdotally reported to induce lithium intoxication. ... 

ESKD (see Chap. 44), necessitating dialysis or transplantation for survival (see Chaps. 45 and 87). The rate of progression can be slowed and in some cases halted through dietary modification and blood pressure control, angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker therapy, and improved glucose control in patients with type I diabetes mellitus (see Chap. 43). The efficacy of these interventions is optimally assessed with serial measurements of accurate and sensitive indices of GFR such as iohexol, iothalamate, or radioisotope clearances. ... 

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