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Angiotension-converting enzyme inhibitors

SH Kubo, RJ Cody. Clinical pharmacokinetics of the angiotension converting enzyme inhibitors. Clin Pharmacokinet 10 377-391, 1985. [Pg.422]

Fig. 10. Pharmacophores for angiotension-converting enzyme. Distances in nm. (a) The stmcture of a semirigid inhibitor and distances between essential atoms from which one pharmacophore was derived (79). (b) In another pharmacophore, atom 1 is a potential zinc ligand (sulfhydryl or carboxylate oxygen), atom 2 is a neutral hydrogen bond acceptor, atom 3 is an anion (deprotonated sulfur or charged oxygen), atom 4 indicates the direction of a hydrogen bond to atom two, and atom 5 is the central atom of a carboxylate, sulfate, or phosphate of which atom 3 is an oxygen, or atom 5 is an unsaturated carbon when atom 3 is a deprotonated sulfur. The angle 1- -2- -3- -4 is —135 to —180° or 135 to 180°, and 1- -2- -3- -5 is —90 to 90°. Fig. 10. Pharmacophores for angiotension-converting enzyme. Distances in nm. (a) The stmcture of a semirigid inhibitor and distances between essential atoms from which one pharmacophore was derived (79). (b) In another pharmacophore, atom 1 is a potential zinc ligand (sulfhydryl or carboxylate oxygen), atom 2 is a neutral hydrogen bond acceptor, atom 3 is an anion (deprotonated sulfur or charged oxygen), atom 4 indicates the direction of a hydrogen bond to atom two, and atom 5 is the central atom of a carboxylate, sulfate, or phosphate of which atom 3 is an oxygen, or atom 5 is an unsaturated carbon when atom 3 is a deprotonated sulfur. The angle 1- -2- -3- -4 is —135 to —180° or 135 to 180°, and 1- -2- -3- -5 is —90 to 90°.
Another type of antihypertensive agent is a calcium channel blocker. This was discussed under amlodipine (no. 6) in Section 3.6. Finally, angiotension-converting enzyme (ACE) inhibitors are used in severe... [Pg.430]

See other pages where Angiotension-converting enzyme inhibitors is mentioned: [Pg.413]    [Pg.254]    [Pg.405]    [Pg.254]    [Pg.413]    [Pg.254]    [Pg.405]    [Pg.254]    [Pg.665]    [Pg.50]    [Pg.50]    [Pg.204]    [Pg.372]    [Pg.649]    [Pg.418]    [Pg.171]    [Pg.99]    [Pg.64]    [Pg.32]   
See also in sourсe #XX -- [ Pg.430 ]



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Angiotension

Angiotension converting enzyme

Converting enzyme

Converting enzyme inhibitors

Enzyme inhibitors

Enzymes enzyme inhibitor

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