Inhibitors of angiotensin-converting enzyme

Cushman DW, Cheung HS, Sabo EF, Ondetti M A. Design of potent competitive inhibitors of angiotensin-converting enzyme. Carboxyalkanoyl and mercaptoal-kanoyl amino acids. Biochemistry 1977 16 5484-91. 

Schmidt, E., Ghisalba, O., Gygax, D. and Sedelmeier, G. (1992) Optimization of a process for the enzymatic production of fA )-2-hyroxy-4-phenyl butyric acid - an intermediate for inhibitors of angiotensin converting enzymes. Journal of Biotechnology, 24, 315-327. 

Petrillo, E.W. and Spitzmiller, E.R., Synthesis of 2-phosphonopyrrolidine and its substitution for proline in an inhibitor of angiotensin-converting enzyme, Tetrahedron Lett., 4929, 1979. 

Cheung HS, Wang EL, Ondetti MA, Sabo EF, Cushman DW. (1980) Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. Importance of the COOH-terminal dipeptide sequence. J Biol Chem 255 401-407. 

A limited amount of work was also conducted by the group of Schultz to investigate the potential of N-formyl hydroxylamine head group to inhibit HDAC. This bidentate chelating moiety was used successfully in inhibitors of angiotensin converting enzyme and neural endopeptidase, however, in the case of HDAC a 50-fold loss in activity was observed vdth this group (17a-c) [33]. 

Herings RM, de Boer A, Strieker BH, Leufkens HG, Porsius A. Hypoglycaemia associated with use of inhibitors of angiotensin converting enzyme. Lancet 1995 345(8959) 1195-8. 

Robl JA, Sun C-Q et al (1997) Dual metalloprotease inhibitors mercaptoacetyl-based fused heterocyclic dipeptide mimetics as inhibitors of angiotensin-converting enzyme and neutral endopeptidase. J Med Chem 40 1570-1577... 

Saunders, J. Inhibitors of Angiotensin Converting Enzyme as Effective Antihypertensive Agents. In Top Drugs Top Synthetic Routes (Chapter 1). Oxford, UK Oxford University Press, 2000. 

M. A. Design of Potent Competitive Inhibitors of Angiotensin-Converting Enzyme Carboxyalkanoyl and Mercaptoalkanoyl Amino Acids. Biochemistiy. 1977, 16, 5484-5491. 

Hypercholesterolemia in the patients with persistent nephrotic syndrome should be treated. Statins are similarly effective as in nonnephrotic subjects and are able to reduce total and LDL cholesterol by about 30% (M2). Reduction of proteinuria by inhibitors of angiotensin-converting enzyme is also able to reduce LDL cholesterol (M2). Dietary therapy seems to be less effective. 

JA Robl, C Sun, J Stevenson, DE Ryono, LM Simpkins, MAP Cimarusti, T Dejneka, WA Slusarchyk, S Chao, L Stratton, RN Misra, MS Bednarz, MM Asaad, HS Cheung, BE Aboa-Offei, PL Smith, PD Mathers, M Fox, TR Schaeffer, AA Seymour, NC Trippodo. Dual metalloprotease inhibitors mercaptoacetyl-based fused heterocyclic dipeptide mimetics as inhibitors of angiotensin-converting enzyme and neutral endopeptidase. J Med Chem 40 1570-1577, 1997. 

DS Karanewsky, MC Badia, DW Cushman, JM DeForrest, T Dejneka, MJ Loots, MG Perri, EW Petrillo, JR Powell. (Phosphinyloxy)acyl amino acid inhibitors of angiotensin converting enzyme (ACE). 1. Discovery of (S)-l-[6-amino-2-[[hy-droxy(4-phenylbutyl)phosphinyl]oxy]-l-oxohexyl]-L-proline, a novel orally active inhibitor of ACE. J Med Chem 31 204-212, 1988. 

Important Snake Venom Peptide Inhibitors of Angiotensin-Converting Enzyme... 

Meisel, H. and Schlimme, E. 1994. Inhibitors of angiotensin converting enzyme derived from bovine casein (casokinins). In (3-Casomorphins and Related Peptides Recent Developments (V. Brand and H. Teschemacher, eds), pp. 27-33. VCH, Weinheim. 

A58365AandA58365B Streptomyces chromofuscus Inhibitors of angiotensin converting enzyme... 

Peptide sequences related to those of snake venom peptides had already been used to define the structural requirements for peptide inhibitors of angiotensin-converting enzyme. Peptides are unstable in vivo and poorly ab-... 

Stage renal failure, where the hypertension can provoke heart failure and leakage of fluid into the lungs (pulmonary edema). This hj ertension can be treated with dietary restriction of salt and water, and with drugs (inhibitor of angiotensin-converting enzyme). 

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