INTRINSIC BINDING ENERGY

Bartlett P A and C K Marlowe 1987. Evaluation of Intrinsic Binding Energy from a Hydrogen-bondi Group in an Enzyme Inhibitor. Science 235 569-571. 

FIGURE 16.2 The intrinsic binding energy of the enzyme-snbstrate (ES) complex (AGi ) is compensated to some extent by entropy loss dne to the binding of E and S (TAS) and by destabilization of ES (AGt) by strain, distortion, desolvation, and similar effects. If AGi, were not compensated by TAS and AG, the formation of ES would follow the dashed line. 

P. A. Bartlett, and C. K. Marlowe, Evaluation of intrinsic binding energy from a hydrogen... 

In recent years attention has focused on the role of intrinsic binding energy and entropic factors as major contributors to enzyme catalytic efficiency (Page and Jencks, 197l Jencks, 1975,1981). The ribonuclease mechanism conforms to expectations based on these ideas. In particular, distortion occurs to raise the ground state of the substrate in the S complex, and the bound substrate interacts with the enzyme in a manner such that the enzyme becomes complementary to the transition state of the reaction during the catalytic cycle. 

Amyes, T.L., O Donoghue, A.C., Richard, J.P. (2001) Contribution of phosphate intrinsic binding energy to the enzymatic rate acceleration for triosephosphate isomerase. J. Am. Chem Soc. 123, 11,325-11,326. 

Although it is likely that the enzyme must use its cofactor-enzyme intrinsic binding energy [9] to weaken the Co—C bond or otherwise trigger the Co—C... 

In other words, the intrinsic binding energies of the two steps are additive but not the entropy losses [130], which means that the intrinsic binding free energy of the first step AG1 (carb) contributes to NCA stabilization. On the other hand, free energies corresponding to the overall entropy losses as-... 

There is a striking similarity between the CO2-promoted catalytic pathway (Scheme 36) and the usual representation of enzymatic catalysis. It is because both processes are partly based on the concept of induced intramolec-ularity [44], Except the nature of binding, there is indeed no fundamental difference between the utilization of the intrinsic binding energy from the... 

Comparing "Equation 16" with "Equation 14" where in the latter the maximum intrinsic binding energy was assumed to be in the activated TS complex and taking into consideration AGf, to be originally... 

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