Modification of Chemical Reactivity Enzyme Inhibitors

A third example of this approach concerns artemisinin derivatives, and it will be developed in Chapter 4. 

Modifications of the chemical reactivity generated by the presence of fluorine atoms in a molecule are connected to three main factors the strength of the C— F bond, the electron-withdrawing character of the fluorinated substituents, and the possible loss of a fluoride ion or of HF in the processes of )S-elimination. On these bases and taking into account the ability of fluoro-substituents to sterically or electronically mimic other 

---