Hypoglycemia enzyme inhibitors

Arauz Pacheco C, Ramirez LC, Rios JM, Raskin P. Hypoglycemia induced by angiotensin-converting enzyme inhibitors in patients with non-insulin-dependent diabetes receiving sulfonylurea therapy. Am JMed (1990) 89, 811-13. 

Pyruvate carboxylase is a mitochondrial enzyme in animal cells, whereas PEPCK is almost exclusively mitochondrial in some species (e.g., pigeons) and cytosolic in others (e.g., rats and mice). In humans (and guinea pigs), PEPCK occurs in both mitochondria and cytosol. An interesting consequence of this species differences is that quinolinate, an inhibitor of cytoplasmic PEPCK, causes hypoglycemia in rats but is less active in humans and guinea pigs. 

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