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Multisubstrate analog enzyme inhibitors

A substrate analog will frequently inhibit only one of the two forms of a multisubstrate enzyme with a ping-pong mechanism.1 72 Reciprocal plots made for various inhibitor concentrations consist of a family of parallel lines reminiscent of uncompetitive inhibition. Observation of such parallel line plots can support a ping-pong mechanism for an enzyme but cannot prove it because in some cases parallel lines are observed for inhibition of enzymes acting by an ordered sequential mechanism. The following question arises naturally for any ordered bimolecular reaction (Eq. 9-43) Of the... [Pg.475]

See other pages where Multisubstrate analog enzyme inhibitors is mentioned: [Pg.363]    [Pg.436]    [Pg.741]    [Pg.742]    [Pg.6]    [Pg.689]    [Pg.113]    [Pg.713]    [Pg.144]    [Pg.15]   
See also in sourсe #XX -- [ Pg.720 , Pg.741 , Pg.742 , Pg.743 , Pg.744 , Pg.745 , Pg.746 , Pg.747 ]

See also in sourсe #XX -- [ Pg.720 , Pg.741 , Pg.742 , Pg.743 , Pg.744 , Pg.745 , Pg.746 , Pg.747 ]



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Analogous enzymes

Enzyme analogs

Enzyme inhibitors

Enzymes enzyme inhibitor

Multisubstrate enzyme

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