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Antihypertensive drugs angiotensin-converting enzyme inhibitors

The most potentially serious drug interactions include the concomitant use of NSAIDs with lithium, warfarin, oral hypoglycemics, high-dose methotrexate, antihypertensives, angiotensin-converting enzyme inhibitors, fi-blockers, and diuretics. [Pg.28]

Antihypertensive therapy should be initiated in diabetic or nondiabetic CKD patients with an angiotensin-converting enzyme inhibitor (ACEI) or an angiotensin II receptor blocker. Nondihydropyridine calcium channel blockers are generally used as second-line antiproteinuric drugs when ACEIs or angiotensin II receptor blockers are not tolerated. [Pg.873]

Angiotensin-converting enzyme inhibitors have turned out to be very effective antihypertensive drugs that have begun to overtake )3-adrenoblockers, especially in monotherapy of hypertension. [Pg.305]

Moreover, whether or not hypertension is caused by an elevated level of renin or other reasons, angiotensin-converting enzyme inhibitors lower both systolic and diastolic arterial pressure in hypertensive patients, and their effects are enhanced by diuretics. Angiotensin-converting drugs of this series (captopril, enalapril) are effective antihypertensive drugs used both independently and in combination with other drugs to treat all types of hypertension as well as to treat cardiac insufficiency. [Pg.306]

Cushman, D. W., Cheung, H. S., Sabo, E. F., and Ondetti, M. A. (1981). Angiotensinconverting enzyme inhibitors Evaluation of a new class of antihypertensive drugs. In "Angiotensin-Converting Enzyme Inhibitors Mechanism of Action and Clinical Implications", (Z. P. Horovitz, Ed.), pp. 1-25. Urban and Schwarzenberg, Baltimore and Munich. [Pg.100]

The effects of antihypertensive agents have been evaluated in patients taking ciclosporin. Collectively, dihydropyridine calcium channel blockers that do not affect ciclosporin blood concentrations substantially or at all (felodipine, isradipine, and nifedipine) are usually considered to be the drugs of choice. However, the risk of gingival hyperplasia with nifedipine, which ciclosporin also causes, should be borne in mind. Combination therapy with angiotensin-converting enzyme inhibitors or beta-blockers, or the use of other calcium channel blockers (verapamil or diltiazem) should also be considered, but careful monitoring of ciclosporin blood concentrations is recommended with the latter because they inhibit ciclosporin metabolism. [Pg.744]

NSAIDs interfere with the antihypertensive action of angiotensin-converting enzyme inhibitors the other drugs listed enhance the blood pressure-lowering effects of captopril and other members of the pril drug family. The answer is (C). [Pg.537]

Unfortunately, this reaction has not yet reached its fid potential for the stereoselective total synthesis of natural products. It is easy to recognize that piperazic acid derivatives 201 could develop from an azo Diels-Alder reaction. These nonproteinogenic cyclic a-hydrazino acids are widely found in depsipeptide natural products like the antimycobacteria lydiamycins 202 isolated from the fermentation broth of Streptomyces lycidus or in cdazapril 203 an angiotensin-converting enzyme inhibitor used as an antihypertensive drug by Hoffman-Laroche (Scheme 41.43). ... [Pg.1273]

Thiazide diuretics have a venerable history as antihypertensive agents until the advent of the angiotensin-converting enzyme (ACE) inhibitors this class of drugs completely dominated first line therapy for hypertension. The size of thi.s market led until surprisingly recently to the syntheses of new sulfonamides related to the thiazides. Preparation of one of the last of these compounds starts by exhaustive reduction of the Diels-Alder adduct from cyclopentadiene and malei-mide (207). Nitrosation of the product (208), followed by reduction of the nitroso group of 209,... [Pg.50]

One of the hrst angiotensin converting enzyme (ACE) inhibitors was teprotide. It is an antihypertensive drug for use after heart attacks. The active ingredient was isolated from the venom of a South American viper snake. Other well-known ACE inhibitors such as captopril and analopril were developed based on modifications to the venom chemical structures. [Pg.55]

Their antihypertensive efficacy is comparable to that of (3-adrenergic blockers and angiotensin-converting enzyme (ACE) inhibitors. The choice of a calcium channel blocker, especially for combination therapy, is largely influenced by the effect of the drug on cardiac pacemakers and contractility and coexisting diseases, such as angina, asthma, and peripheral vascular disease. [Pg.221]


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See also in sourсe #XX -- [ Pg.282 ]




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Angiotensin antihypertensives

Angiotensin converting enzyme

Angiotensin inhibitor

Angiotensin-converting

Angiotensin-converting enzyme inhibitor

Antihypertension drugs

Antihypertensive drugs

Converting enzyme

Converting enzyme inhibitors

Enzyme inhibitors

Enzymes drugs

Enzymes enzyme inhibitor

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