Nonpeptide ligands

Significant progress has been made in the development of nonpeptidic ligands for the GAL3 receptor (Fig. 1). 3-Arylimino-2-indolones including SNAP 37889 and SNAP 398299 were shown by Swanson... 

Plummer MS, Holland DR, Shahripour A, Lunney EA, Fergus JH, Marks JS, McConnell P, Mueller WT, Sawyer TK. Design, synthesis, and cocrystal structure of a nonpeptide Src SH2 domain ligand. J Med Chem 1997 40 3719-3725. 

Lunney EA, Para KS, Rubin JR, Humblet C, Fergus JH, Marks JS, Sawyer TK. Structure-based design of a novel series of nonpeptide ligands that bind to the pp60c"src SH2 domain. J Am Chem Soc 1997 119 12471-12476. 

JH. Discriminative stimulus effects of BW373U86 a nonpeptide ligand with selectivity for delta opioid receptors. J Pharmacol Exp Ther 1993 267 888-895. 

Nonpeptide Agonists Bind in the Deep Part of the Main Ligand-Binding... 

Recently, nonpeptide compounds have been developed for many peptide receptor systems. These compounds, which usually are discovered through screening of chemical files, generally do not resemble the corresponding peptide ligands chemically. Nevertheless, they act as specific and... 

E. R. Hickey, S. Jakes, A. Kabcenell et al. Nonpeptidic, monocharged, cell permeable ligands for the p561ck SH2 domain, J. Med. Chem. 2001, 44, 2421-2431... 

Xue J-C, Chen C, Zhu J et al. Differential binding domains of peptide and nonpeptide ligands in the cloned rat A-opioid receptor. J Biol Chem 1994 269 30195-30199. 

Rzepecki, P., Nagel-Steger, L., Feuerstein, S., et al. (2004) Prevention of Alzheimer s disease-associated AP aggregation by rationally designed nonpeptide P-sheet ligands. J. Biol. Chem., 279,47497 7505. 

Sawada Y, Kayakiri H, Abe Y, et al. A new class of nonpeptide bradykinin B2 receptor ligands, incorporating a 4-aminoquinoline framework. Identification of a key pharmacophore to determine species difference and agonist/antagonist profile. 7 Med Chem 2004 47 2667-77. 

Feng et al. " used combinatorial synthesis to discover several ligands containing nonpeptide binding elements to... 

LRG4, LRG5, LRG6 Glycoproteins LH/FSH nonpeptide ligands... 

Zaveri N. Peptide and nonpeptide ligands for the noci-ceptin/orphanin FQ receptor ORLl research tools and potential therapentic agents. Life Sci 2003 73(6) 663-78. 

Phage display techniques can be used in any field where molecular biological approaches find application. It can be successfully used for epitope mapping, vaccine development, identification of proteinkinase substrates and nonpeptid ligands, selection of functional interactions of hormones, enzymes, enzyme inhibitors, mapping... 

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