Smoke, tobacco

A large number of polycyclic aromatic hydrocarbons are known Many have been synthesized m the laboratory and several of the others are products of com bustion Benzo[a]pyrene for example is present m tobacco smoke contaminates food cooked on barbecue grills and collects m the soot of chimneys Benzo[a]pyrene is a carcinogen (a cancer causing substance) It is converted m the liver to an epoxy diol that can induce mutations leading to the uncontrolled growth of certain cells... 

Tobacco smoke contains a variety of air pollutants. In a survey of 80 homes ia an area where the outdoor TSP varied between 10—30 lg/m, the iadoor TSP was the same, or less, ia homes having ao smokers. la homes having oae smoker, the TSP levels were betweea 30—60 lg/m, while ia homes having two or more smokers, the levels were betweea 60—120 lg/m (64). la other studies, iadoor TSP levels exceeding 1000 lg/m have beea fouad ia homes with aumerous smokers. la additioa to TSP, burning tobacco emits CO, NO formaldehyde [50-00-0] bea2opyreaes, nicotine [54-11-5] pheaols, and some metals such as cadmium [7440-43-9] and arsenic [7440-38-2] (65). 

Sources of human exposure to formaldehyde are engine exhaust, tobacco smoke, natural gas, fossil fuels, waste incineration, and oil refineries (129). It is found as a natural component in fmits, vegetables, meats, and fish and is a normal body metaboHte (130,131). FaciUties that manufacture or consume formaldehyde must control workers exposure in accordance with the following workplace exposure limits in ppm action level, 0.5 TWA, 0.75 STEL, 2 (132). In other environments such as residences, offices, and schools, levels may reach 0.1 ppm HCHO due to use of particle board and urea—formaldehyde foam insulation in constmction. 

I. K. O Neill, J. Chen, and H. Bartsch, eds.. Relevance to Human Cancer of N-Nitroso Compounds, Tobacco Smoke andMjcotoxins, lARC Scientific Pubhcation No. 105, International Agency for Research on Cancer, Lyon, Prance, 1991. 

The two isomeric butanals, n- and isobutyraldehyde, C HgO, are produced commercially abnost exclusively by the Oxo Reaction of propylene. They also occur naturally ia trace amounts ia tea leaves, certain oils, coffee aroma, and tobacco smoke. 

National Research Council. (1986b). "Environmental Tobacco Smoke Measuring Exposures and Assessing Health Effects." National Academy Press, Washington, DC. 

Airborne material affecting the quality of indoor air may be classified as gases or particulate matter. Gases which may be potential problems are radon, CO, NOj, and hydrocarbons. Particulate matter may come from tobacco smoke, mold spores, animal dander, plant spores, and others as shown in Table 23-1. Other factors interact to influence our perception of indoor air quality, including humidity, temperature, lighting, and sound level. 

Effects of indoor air pollutants on humans are essentially the same as those described in Chapter 7. However, there can be some additional pollutant exposures in the indoor environment that are not common in the ambient setting. From the listing in Table 23-1, radon exposures indoors present a radiation hazard for the development of lung cancer. Environmental tobacco smoke has been found to cause lung cancer and other respiratory diseases. Biological agents such as molds and other toxins may be a more likely exposure hazard indoors than outside. 

Cleaning solutions Tobacco smoke Air-conditioning systems Water treatment Humidifiers Disinfectants Exhaled breath Vehicle exhausts Smoking chimneys Portable heaters Tobacco smoke Gas cookers Gas and oil heaters... 

Ozone Tobacco smoke Gas heaters Electrical discharges from equipment such as photocopiers, electrostatic... 

Smoke - Smoke constitutes fine, solid, gasbome matters that are products of incomplete combustion of organics (wood, coal, tobacco). Smoke particles are extremely small, ranging in size from less than 0.01 /im to 1 /im. 

Environmental Tobacco Smoke (ETS) mixture of smoke from the burning end of a cigarette, pipe, or cigar and smoke exhaled by the smoker (also secondhand smoke or passive smoking). 

Compounds that induce bronchoconstriction include tobacco smoke, formaldehyde, and diethyl ether. Several other compounds, such as acidic fumes (e.g., sulfuric acid) and gases, such as ozone and nitrogen dioxide, as well as isocyanates, can cause bronchoconstriction. Also, cellular damage in the airways induces bronchoconstriction because of the release of vasoactive compounds. Frequently, different mechanisms work at the same time, provoking bronchoconstriction and increased secretion of mucus, both of which interfere with respiration. 

Chronic Pulmonary Toxicity Chronic damage to the lungs may be due to several subsequent exposures or due to one large dose that markedly exceeds the capacity of pulmonary defense, clearance, and repair mechanisms. Chronic pulmonary toxicity includes emphysema, chronic bronchitis, asthma, lung fibrosis, and lung cancer. The single most important reason for chronic pulmonary toxicity is tobacco smoke, which induces all types of chronic pulmonary toxicity, with the exception of fibrosis. 

Compounds Affecting Rq>roduction Compounds that can affect reproductive function include several drugs and occupationally important chemicals such as solvents and pesticides as well as a number of environmentally relevant com-fxrunds. A group of chemical compounds that has received much attention recently is endocrine disrupters, many of which are halogenated hydrocarbons, e.g., PCBs. These are known to induce feminization in fish and other animal species.1.5/ There is intense debate about the significance of these compounds to human health. Tobacco smoke and ethyl alcohol also have major effects on human reproduction, the effects of alcohol being especially important. Table 5.17 lists compounds that may disturb the functions of female and male reproductive functions. 

FAS is normally characterized by growth retardation, anomalies of the head and face, and psychomotor dysfunctions. Excessive consumption of ethyl alcohol may lead to malformations of the heart, extremities, and kidneys. Since consumption of ethyl alcohol is socially acceptable and prevalent even in pregnant women, the risks associated with the use of ethyl alcohol are remarkable. However, it should be kept in mind that there are several chemical compounds in tlie occupational environment that may also cause malformations even at low doses. The oc-cupationally-important known human teratogens include methyl mercury, ethyl alcohol, PCB compounds, tobacco smoke, lead, TCDD, 2,4,5- F, carbon monoxide, nitrogen dioxide, gasoline, and fluoride. 

If the light-scattering objects originally present in the airflow are unsuitable for LDA measurements due to insufficient concentration or incorrect estimated flow-tracking capability, the air must be seeded with oil smoke, tobacco smoke, or titanium dioxide tracer particles or droplets. A simple smoke candle is generally suitable for seeding, even if the enclosure is large and the air path is not closed as in several cases of industrial ventilation. 

The first experiment with the electrostatic gas cleaning was made in 1824, when Hohlfeld show that a fog was cleared from a glass jar which contained an electrically charged point electrode. Similar demonstrations were published in the 19th century, an example being the precipitation of tobacco smoke in a glass cylinder by Guitard (1850). 

Tobacco and its alkaloids have long ceased to have any therapeutic importance, but their extensive use as insecticides and the demand for nicotine for the manufacture of nicotinic acid have stimulated interest in processes of extraction and methods of estimation. On the latter subject there is a voluminous literature, of which critical resumes have been published by various authors.Recent work on this subject has been specially concerned with (1) the development of miero- and semi-miero-methods suitable for estimating nieotine in tobacco smoke and the distribution of nieotine on sprayed garden produce, in treated soils and in tobaeeo leaves,(2) the study of conditions necessary to ensure satisfactory results in using particular processes, " and (3) methods of separation and estimation of nicotine, nomicotine and anabasine in mixtures of these bases. ) In the United States and in Russia considerable interest is being shown in the cultivation of types of tobacco rich in nicotine, in finding new industrial uses for tobacco and its alkaloids, and in possible by-products from tobacco plants such as citric and malic acids, i " Surveys of information on tobacco alkaloids have been published by Jackson, i Marion and Spath and Kuffner. ... 

Alkaloids of Tobacco Smoke. The following alkaloids, apart from normal alkaloidal constituents of tobacco, have been isolated by Wenusch and Schoeller from tobaceo smoke. 

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