Tobacco smoke organic solvents

Moszczynski P, Slowinski S, Moszczynski P. Synergistic effect of organic solvents and tobacco smoke on the indicators of humeral immunity in humans. Gig Tr Prof Zabol 1991 3 34-6. 

Tobacco smoke. Tobacco smoke produces particulate matter that acts as an adsorption site for toxic vapors)26 In addition to particulates, tobacco smoke produces more than 4000 individual toxic compounds, including 43 known carcinogens. 27 Many of the toxic effects of tobacco smoke that have been established empirically cannot be ascribed to individual compounds in that smoke. With more than 4000 different toxins, the number of mixtures possible is incalculable. Numerous examples of synergism between tobacco smoke and other toxicants have been identified. These include tobacco smoke and asbestos or other mineral fibers, I28 29 alcohol, I30 31 organic solvents, 32 biological... 

Moszczynski P, Lisiewicz J, Slowinski S. Synergistic effects of organic solvents and tobacco smoke on serum immunoglobulin levels in humans. Med Pr 1989 40(6) 337 41. 

Smoking enhances the immunotoxicity of aromatic solvents. Tobacco smoke and organic solvents acting alone are immunotoxins that reduce antibody levels in blood serum. The reduction of serum IgA, IgG, and IgM levels are enhanced (relative to solvent or smoking effects alone) when smokers are occupationally exposed to benzene and its homologs. I65l... 

Both tobacco smoke and aromatic organic solvents when acting separately diminish serum immunoglobulin levels in humans. Tobacco smoke as well as benzene and its homologs decrease serum IgA and IgG levels. Tobacco smokers also have reduced IgM levels. The serum of tobacco smokers occupationally exposed to benzene and its homologs has been shown to have levels of all three immunoglobulins reduced to a greater... 

Only a very few studies have documented the toxic effects of chemical mixtures on the musculoskeletal system. Almost all of these studies address the effects of tobacco smoking and organic solvent exposure. The following studies are illustrative of those reported. 

Table 9 Volatile organic compounds (VOC) (nonmicrobial) sources of selected indicator MVOC. (Artificial) flavoring (I),beer (2), cauliflower (boiled) (3), coating materials (4), fat (5), cream components (6), essential oil (7), paints (8), coffee (9), coffee flavoring (10), cabbage (II), coconut fat (12), varnishes (13),solvents (14),perfumes (15),leeks (cooked) (16), cleaning agents (17), air freshener (IS), ointment (19), shellfish (cooked) (20), chives (21), tobacco smoke (22) ...

Xylenols which are clear crystalline compounds soluble in alcohol, acetone, and many organic solvents, are present in various essential oils and also in tea, tobacco, roasted coffee, and in various smoked foods. In some cases xylenols contribute to the flavor of these products [1]. 

Many of the isomeric Cg through Cgg alkanes have been identified in the organic solvent-soluble extracts from one or more of the major tobacco types (flue-cured, burley. Oriental, Maryland). Their presence in tobacco smoke is the result of their volatilization during the puff and smolder phases of the smoking process and subsequent direct transfer from the tobacco to its MSS and sidestream smoke (SSS). The bulk of these higher alkanes are found in the particulate phase of the smoke aerosol with traces of the lower ones (Cg-Cij) in the vapor phase. 

From the mid-1960s to the early 1970s, the USDA gronp described the pyrolysis of organic-solvent extractables from tobacco. In the earlier stndies, the pertinence of the pyrolysis results in defining the precnrsors in tobacco of the PAHs in the CSC was emphasized (3465, 3455), bnt snbseqnent research dealt with the precnrsors in tobacco of the simple phenols in cigarette smoke (3456, 3468). 

Matthews, J.E. Smoke technique and analysis 2nd Tobacco Chemists Research Conference, Program Booklet and Abstracts, Vol. 2, Paper No. 8, 1948, p. 1. Matthey, E. Efficacite du traitement prealable du tabac par un solvent organique, du point de vue de la reduction des substances toxiques dans la fumee [Effectiveness of the preliminary treatment of tobacco with an organic solvent, from the point of view of the reduction of the toxic substances in the smoke] Z. Praventivmed. 6 (1961)428 3. 

Mouron, J.-C., J. Bonnet, and S. Neukomm Extraction of tobacco by some organic solvents and consequences on chemical composition of the smoke Oncologia 13 (1960) 271-278. 

Hash oil This is a manufactured product of cannabis and is produced by extracting the whole plant material using an organic solvent (usually alcohol or ether). On extraction the resulting oil can contain between 10 and 30% by weight of A -THC. The oil is used in various ways including smoking with tobacco. 

Apart from the separation of components of tobacco smoke, atmospherie pollutants, solvents, plant extracts, essential oils, volatile vegetable oils and organic acids etc., for which it is routinely used, gas chromatography is being increasingly used as an analytical tool to study... 

Smoking enhances the immunotoxicity of aromatic solvents. Tobacco smoke and organic solvents acting alone are immunotoxins that reduce antibody levels in blood... 

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