A-Nitrosamines in tobacco smoke

In its 1986 monograph on tobacco smoking, the International Agency for Research on Cancer (lARC) discussed many of the details of A-nitrosamines and tobacco-specific A-nitrosamines in tobacco smoke. Despite the reports prior to 1985 on the identification in tobacco smoke of many nitro components (1755, 1758, 2137, 3086), lARC listed only one nitro compound, 2-nitropropane, as a biologically active smoke component [see Table 19, pp. 86-87 in (1870)]. In its listing of the evaluation of tobacco smoke components for... 

The U.S. Surgeon General [see p. 200 in (4010)], on the subject of A-nitrosamines in tobacco smoke, stated There is lack of direct evidence that these compounds are also human carcinogens. This was also the view of Magee, who first demonstrated the tumorigenicity of A-nitrosamines in... 

Bmnnemann, K.D., J.E. Cox, Y. Liu, and D. Hoffmann Analysis of volatile and tobacco-specific A-nitrosamines in tobacco smoke by conventional method and by supercritical fluid extraction 46th Tobacco Chemists Research Conference, Program Booklet and Abstracts, Vol. 46, Paper No. 22, 1992, pp. 33-34. 

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