F-5 Possible tryptophan-derived compounds in tobacco smoke

FIGURE XVII.F-5 Possible tryptophan-derived compounds in tobacco smoke. 

On the other hand, it is also true that human beings are being exposed to many heterocyclic amines and many other carcinogens with tumor promoters and/or suppressing factors 

As in the case of the carcinogens whose activity can be substantially reduced by anticarcinogens [see review by Rodgman (3255)], Lee et al. (2327c) reported that mainstream CSC significantly inhibited the mutagenicity of several of these A-heterocyclic amines when tested in the Ames assay with Salmonella typhimurium, strain TA 98 in the presence of the S-9 mix. The A-heterocyclic amines tested included 2-amino-3-methylimidazo[4,5-/]quinoline (IQ), 2-amino-3,4-dimethylimidazo[4,5-/]quinoline (MelQ), 2-amino-6-methyl-dipyrido[l,2-fl 3 ,2 - /]imidazole(Glu-P-l), 2-aminodipyrido[l,2-fl 3 ,2 - /]imidazole (Glu-P-2), 3-amino- 

Although many of the A-heterocyclic amines are indeed present in cigarette MSS, it should be remembered that the 

Summary of Lists of Tumorigenic A/-Heterocyclic Amines in Tobacco Smoke 

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