Mesenchymal stem cell

Chun C, Lim HJ, Hong KY et al (2009) The use of injectable, thermosensitive poly (organophosphazene)-RGD conjugates for the enhancement of mesenchymal stem cell osteogenic differentiation. Biomaterials 30 6295-6308... [Pg.167]

Figure 7.3. All skeletal tissues arise from a single cell type, the mesenchymal stem cell. Differentiation into bone, cartilage, muscle, or ligament occurs in response to the mechanical and biochemical stimuli of the stem cell s environment.

It has even been demonstrated that CXCR4-expressing mesenchymal stem cells can enter the brain following stroke (Hill et al. 2004) or under other circumstances (Sano et al. 2005). Indeed, a population of CXCR4-expressing cells that also... [Pg.199]

Ortiz LA, Gambelli F, McBride C, et al. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci U S A 2003 100(14) 8407-8411. [Pg.311]

Neuss and coworkers have reported the possibility of SMPs using PCL dimethacrylate copolymers as cellular scaffold for tissue engineering. Behaviors of different cells from three different species (human mesenchymal stem cells, human mesothelial cells, and rat mesothelial cells) on the matrices were investigated, and the differentiation capacity of mesenchymal stem cells on the matrices was also analyzed [329]. The SMPs proved biocompatibility for all tested cell types, supporting viability and proliferation. The SMPs also supported the osteogenic and adipogenic differentiation of human mesenchymal stem cells 3 weeks after induction. [Pg.105]

Cell transplantation has shown promise as a method for treating serious diseases. Various kinds of pluripotent stem cells have been developed or identified, including embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and mesenchymal stem cells (MSCs). Moreover, the differentiation of stem cells to functional cells has been extensively studied. Previous studies have demonstrated that the transplantation of islet of Langerhans cells (islets) could successfully treat type 1 diabetes. Islets are insulin-secreting cells found in the pancreas. Over 200 patients... [Pg.189]

In an attempt to mimic the physiological ratio of collagen type II to hyaluronan in the healthy human NP, Calderon et al. constructed hydrogels scaffolds composed of these two elements in a 9 1 (w/w) ratio [104]. Scaffolds were crosslinked with various concentrations of EDC/NHS, but it was found that 8 mM EDC/NHS resulted in a confined compressive modulus on the order of the native NP, while allowing for optimal rat mesenchymal stem cell (rMSC) viability and proliferation. Additionally, real time PCR results from rMSCs seeded on the scaffolds for 21 days indicated that the scaffolds promoted increased aggrecan expression and inhibited collagen type I expression compared to rMSCs cultured on monolayers. [Pg.215]

Richardson SM et al (2008) Human mesenchymal stem cell differentiation to NP-like cells in chitosan-glycerophosphate hydrogels. Biomaterials 29(1 ) 85—93... [Pg.228]

Korecki CL et al (2010) Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation toward a young nucleus pulposus phenotype. Stem Cell Res Ther 1(2) 18... [Pg.229]

Pittenger MF et al (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284(5411) 143-147... [Pg.229]

Aggarwal S, Pittenger MF (2005) Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 105(4) 1815-1822... [Pg.229]

Steck E et al (2005) Induction of intervertebral disc-like cells from adult mesenchymal stem cells. Stem Cells 23(3) 403 f11... [Pg.229]

Risbud M, Izzo M, Adams C et al. (2003) Mesenchymal stem cells respond to their microenvironment and in vitro to assume nucleus pulposus-like phenotype. Paper presented at 30th Annual Meeting of the International Society for the Study of the Lumbar Spine. Vancouver, Canada... [Pg.229]

Richardson SM et al (2006) Intervertebral disc cell-mediated mesenchymal stem cell differentiation. Stem Cells 24(3) 707-716... [Pg.229]

Sakai D et al (2006) Regenerative effects of transplanting mesenchymal stem cells embedded in atelocollagen to the degenerated intervertebral disc. Biomaterials 27(3) 335-345... [Pg.229]

Angelopoulou M, Novell E, Grove JE et al. Cotransplantation of human mesenchymal stem cells enhances himian myelopoiesis and megakaryoc34opoiesis in NOD/SCID mice. Exp Hematol. 2003 31 413 420. [Pg.61]

Based on this background, the objective of our studies was to test the therapeutic potential of mesenchymal stem cells, administered to rats following induction of MI or AKI by ischemia/reperfusion (I/R), and to monitor their physical presence in the injured organ using magnetic resonance imaging (MRI) and histology. [Pg.107]

For MRI or histological tracking of MSG in vivo, cultured mesenchymal stem cells were prelabeled for 24 hours with carboxy-dextran-coated iron oxide nanoparticles (Resovist, Schering, Berlin, Germany) (Ittrich et al, 2005 Lange et al., 2005b). [Pg.107]

Sedated and anaesthetized rats received a lateral (mini-) thoracotomy and a pistil (3x6mm chilled to -193° G) was advanced through the hole in the chest and pressed onto the surface of the heart for 30 sec. The procedure was repeated 10 times in order to generate a cryolesion of reproducible size. GFP-transduced mesenchymal stem cells were directly injected into the borderzone of the developing ischemia (2x left lateral, 2x right lateral, lx apical). Each injection contained 8x10 mesenchymal stem cells in a volume of 30 pi (Jaquet et al., 2005). [Pg.107]

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