T-Cell Functions

Fig. 4. Regulatory T-cell functions suppression of DCs that support the generation of effector T cells suppression of ThI, Th2, and ThI 7 cells suppression of allergen-specific IgE and induction of lgG4, IgA, or both suppression of mast cells, basophils, and eosinophils interaction with resident tissue cells and remodeling, and suppression of effectorT-cell migration to tissues. 

Type IV reactions are mediated by T cells themselves. Delayed-type hypersensitivity reactions from positive tuberculin tests to contact dermatitis are typical type IV reactions, but understanding T-cell function allows us to further define this category, as shown in Table 51-1. 

Buttner C, Lun A, Splettstoesser T, Kunkel G, Renz H. Monoclonal antiinterleukin-5 treatment suppresses eosinophil but not T-cell functions. Eur Respir J 2003 21(5) 799-803. 

Volume 150. Immunochemical Techniques (Part K In Vitro Models of B and T Cell Functions and Lymphoid Cell Receptors)... 

Adkins, B. T-cell function in newborn mice and humans, Immunol. Today, 20, 330, 1999. 

Other acceptable assays include drug effect on NK cell function in vitro bastogenesis, cytotoxic T cell function, cytokine production, delayed-type hypersensitivity, host resistance to infections or implanted tumors. 

Mercaptopurine Antimetaholite acute leukemias arthritis Decreased T-cell function bone marrow suppression... 

Wu Y, Borde M, Heissmeyer V, Feuerer M, Lapan AD, Stroud JC, Bates DL, Guo L, Han A, Ziegler SF, Mathis D, Benoist C, Chen L, Rao A FOXP3 controls regulatory T cell function through cooperation with NFAT. CeU 2006 126 375-387. 

Mempel TR, Pittet MJ, Khazaie K, Weninger W, Weissleder R, von Boehmer H, von Andrian UH Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. Immunity 2006 25 129-141. 

Gelfand EW, Cui ZH, Takeda K, Kanehiro A, Joetham A Fexofenadine modulates T-cell function, preventing allergen-induced airway inflammation and hyperresponsiveness. J Allergy Clin Immunol 2002 110 85-95. 

Wu Y, Borde M, Heissmeyer V, et al FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 2006 126 375-387. 

Sutmuller RP. den Brok MH. Kramer M. et al Toll-llke receptor 2 controls expansion and function of regulatory T cells. J Clin Invest 2006 116 485-494. Zanin-Zhorov A. Cahalon L. Tal G. Margalit R. Lider 0. Cohen IR Heat shock protein 60 enhances CD4+ CD25+ regulatory T cell function via innate TLR2 signaling. J Clin Invest 2006 116 2022-2032. 

Adenosine deaminase (ADA) deficiency, an autosomal recessive disorder, produces severe combined immunodeficiency (SCID). Lacking both B-cell and T-cell function, children are multiply infected with many organisms Pneumocystis carinii, Candida) and do not survive without treatment. Enzyme replacement therapy and bone marrow transplantation may be used. Experimental gene therapy trials have not yet yielded completely successfiil cures. 

HLA-deficient clones to escape T cell responses since T cell function is already immunosuppressed. 

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