Inducible pluripotent stem cells

BIX01294, which inhibits G9a [29], is efficacious as a replacement for oct3/4, one of the four original genetic factors used for reprogramming of mammalian somatic cells into induced pluripotent stem cells [36]. [Pg.335]

Knowledge gained from cell adhesion studies with SAMs has been used to develop culture substrates with the appropriate cell adhesion glycoproteins for different types of cells [7-10], Stem cells, capable of self-renewal and differentiation into multiple cell types, are found in embryonic and adult tissues. Pluripotent stem cells, like embryonic stem cells and induced pluripotent stem cells, have been developed in vitro. These cells are expected to provide cell sources for regenerative medicine. Various culture conditions have been developed to enable expansion of these cells without loss of their multi- and pluripotency and to induce differentiation into viable cells with specific functions. [Pg.169]

Cell transplantation has shown promise as a method for treating serious diseases. Various kinds of pluripotent stem cells have been developed or identified, including embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and mesenchymal stem cells (MSCs). Moreover, the differentiation of stem cells to functional cells has been extensively studied. Previous studies have demonstrated that the transplantation of islet of Langerhans cells (islets) could successfully treat type 1 diabetes. Islets are insulin-secreting cells found in the pancreas. Over 200 patients... [Pg.189]

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Cardiomyocyte-like cells derived from hESCs or human-induced pluripotent stem cells (hiPSCs) recapitulate genomic, biochemical, mechanical, and electrophysiological behaviors of human cardiomyocytes [77, 78] and thus provide an amenable source of cells for in vitro cardiotoxicity testing [79-85],... [Pg.65]

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Rana P, Anson B, Engle S, Will Y (2012) Characterization of human-induced pluripotent stem cell-derived cardiomyocytes bioenergetics and utilization in safety screening. Toxicol Sci 130(1)417-131... [Pg.75]

Use of Induced Pluripotent Stem Cells in Drug Toxicity Screening... [Pg.335]

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Polo JM et al (2010) Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nat Biotechnol 28(8) 848-855... [Pg.348]

Nakagawa M et al (2008) Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat Biotechnol 26(1) 101-106... [Pg.348]

Kim J et al (2008) An extended transcriptional network for pluripotency of embryonic stem cells. Cell 132(6) 1049-1061 Yu J et al (2007) Induced pluripotent stem cell lines derived from human somatic cells. Science 318(5858) 1917-1920... [Pg.348]

Zhou T et al (2012) Generation of human induced pluripotent stem cells from urine samples. Nat Protoc 7(12) 2080-2089 Kang L et al (2009) iPS cells can support full-term development of tetraploid blastocyst-complemented embryos. Cell Stem Cell 5(2) 135-138... [Pg.348]

Liang G, Zhang Y (2013) Embryonic stem cell and induced pluripotent stem cell an epigenetic perspective. Cell Res 23(1 ) 49-69 Wang P, Na J (2011) Mechanism and methods to induce pluripotency. Protein Cell 2(10) 792-799... [Pg.348]

Dimos JT et al (2008) Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science 321(5893) 1218-1221... [Pg.348]

Park IH et al (2008) Disease-specific induced pluripotent stem cells. Cell 134(5) 877-886... [Pg.349]

Sommer CA et al (2009) Induced pluripotent stem cell generation using a single lentiviral stem cell cassette. Stem Cells 27(3) 543-549... [Pg.349]

Woltjen K et al (2009) piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature 458(7239) 766-770... [Pg.349]

Yu J et al (2009) Human induced pluripotent stem cells free of vector and transgene sequences. Science 324(5928) 797-801... [Pg.349]

Lin SL (2011) Concise review deciphering the mechanism behind induced pluripotent stem cell generation. Stem Cells 29(11) 1645-1649... [Pg.349]

Hu BY et al (2010) Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Proc Natl Acad Sci U S A 107(9) 4335 340... [Pg.349]

Zhang J et al (2009) Functional cardiomyo-cytes derived from human induced pluripotent stem cells. Circ Res 104(4) e30-e41 Zwi L et al (2009) Cardiomyocyte differentiation of human induced pluripotent stem cells. Circulation 120(15) 1513-1523 Burridge PW et al (2012) Production of de novo cardiomyocytes human pluripotent stem cell differentiation and direct reprogramming. Cell Stem Cell 10(l) 16-28 Rattman SJ et al (2011) Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and... [Pg.349]

Khan JM, Lyon AR, Harding SE (2013) The case for induced pluripotent stem cell-derived cardiomyocytes in pharmacological screening. Br J Pharmacol 169(2) 304-317... [Pg.350]

Ye L et al (2013) Effective cardiac myocyte differentiation of human induced pluripotent stem cells requires VEGF. PLoS One 8(l) e53764... [Pg.350]

Rashid ST et al (2010) Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. J Clin Invest 120(9) 3127-3136... [Pg.350]

Oh SI, Lee CK, Cho KJ, Lee KO, Cho SG, Hong S (2012) Technological progress in generation of induced pluripotent stem cells for clinical applications. Scientific World J ournal 2012 417809... [Pg.372]

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Du J, Campau E, Soragni E, Ku S, Puckett JW, Dervan PB, Gottesfeld JM (2012) Role of mismatch repair enzymes in GAA-TTC triplet-repeat expansion in Friedreich ataxia induced pluripotent stem cells. J Biol Chem 287(35 ) 29861-29872... [Pg.372]

Shofuda T, Fukusumi H, Kanematsu D, Yamamoto A, Yamasaki M, Arita N, Kanemura Y (2013) A method for efficiently generating neurospheres from human-induced pluripotent stem cells using microsphere arrays. Neuroreport 24(2) 84-90... [Pg.372]

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