Delivery of Mesenchymal Stem Cells

Manning CN, Schwartz AG, Liu W, Xie J, Havlioglu N, Sak ma-Elbert SE, Silva MJ, Xia Y, Gelberman RH, Thomopoulos S (2013). Controlled delivery of mesenchymal stem cells and growth factors using a nanofiber scaffold for tendon repair. Acta Biomater, 9,6905-6914. 

Wang L, Rao RR, Stegemann JP (2013). Delivery of mesenchymal stem cells in chitosan/collagen microbeads for orthopedic tissue repair. Cells Tissues Organs, 197,333-343. 

Deng Y, Guo X, Yuan Q, Li S. Efficiency of adenoviral vector mediated CTLA4Ig gene delivery into mesenchymal stem cells. Chin Med J (Engl) 2003 116 1649-1654. 

Suncion VY, et al. Does transendocardial injection of mesenchymal stem cells improve myocardial function locally or globally an analysis from the Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis (POSEIDON) randomized trial. Circ Res 2014 114 1292-301. 

Santos, J.L., Oliveira, H., Pandita, D., Rodrigues, J., Pego, A.P., Granja, P.L., et al., 2010. Functionalization of poly(amidoamine) dendrimers with hydrophobic chains for improved gene delivery in mesenchymal stem cells. J. Control. Release 144 (1), 55-64. 

Barbash IM, Chouraqui P, Baron J, Eeinberg MS, Etzion S, Tessone A, Miller R, Guetta E, Zipori D, Kedes LH, Kloner RA, Leor J. Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium feasibility, cell migration, and body distribution. Circulation 2003 108 863-868. 

Mode of delivery of human mesenchymal stem cells alfects engraftment of human CD34+ cells in NOD/SCID mice Liu, L., Mbalaviele, G., Lee, K., Mosca, J., Deans, R. 

Saraf A, Hacker MC, Sitharaman B et al (2008) Synthesis and conformational evaluation of a novel gene delivery vector for human mesenchymal stem cells. Biomacromolecules 9 (3) 818-827... 

Another novel cardiovascular therapy that has recently come into play is the use of stem cell delivery. These approaches have thus far involved the use of gene delivery mechanisms to essentially force embryonic stem cells into cardiomyocyte differentiation with the goal of producing a cardiac pace-making cell (Arruda et al., 2004). Researchers are also developing methods for utilizing seeded adult mesenchymal stem cells as an implanted base to act as a depot for the delivery of localized gene therapies (Arruda et al., 2004). 

Meinel, L., Hofmann, S., Betz, O., Fajardo, R., Merkle, H.P., Langer, R., Evans, C.H., Vunjak-Novakovic, G., and Kaplan, D.L. "Osteogenesis by human mesenchymal stem cells cultured on silk biomaterials Comparison of adenovirus mediated gene transfer and protein delivery of BMP-2". Biomaterials 27(28), 4993-5002 (2006b). 

T. Hou, J. Xu, Q. li, J. Feng, L. Zen, In vitro evaluation of a fibrin gel antibiotic delivery system containing mesenchymal stem cells and vancomycin alginate beads for treating bone infections and facilitating bone formation. Tissue Eng. A 14 (7) (2008) 1173-1182. 

Katare, R., Riu, E., Rowlinson, J., Lewis, A., Holden, R., Meloni, M., Reni, C., Wallrapp, C., Emanueh, C., Madeddu, P. Perivascular delivery of encapsulated mesenchymal stem cells improves postischemic angiogenesis via paracrine activation of vegf-a. Arteriosclerosis, Thrombosis And Vascular Biology 33, 1872-1880(2013)... 

AM is innovative in that it fulfills an unmet clinical need with a human tissue-derived solution that does not introduce new materials into the human body. AM addresses a global health issue with an available source of human biomaterial. The product may provide an innovative source of human mesenchymal stem cells and their delivery for tissue regeneration. 

Park JS, Na K, Woo DG et al (2010) Non-viral gene delivery of DNA polyplexed with nanoparticles transfected into human mesenchymal stem cells. Biomaterials 31 124—132... 

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