Nucleus pulposus

Chymopapain [9001 -90-6] derived from the latex of the papaya tree, produces improvement in lower back pain and sciatica in the majority (75%) of recipients (185—189) when injected into the lumbar intervertebral disks of patients suffering from herniated disk (the nucleus pulposus). This treatment degrades the proteoglycans of the diseased nucleus pulposus, resulting in shrinkage of the disk and reduction of pressure on the nerve roots (190). [Pg.311]

Advances in Tissue Engineering Approaches to Treatment of Intervertebral Disc Degeneration Cells and Polymeric Scaffolds for Nucleus Pulposus Regeneration... [Pg.201]

Abstract Synthetic polymers and biopolymers are extensively used within the field of tissue engineering. Some common examples of these materials include polylactic acid, polyglycolic acid, collagen, elastin, and various forms of polysaccharides. In terms of application, these materials are primarily used in the construction of scaffolds that aid in the local delivery of cells and growth factors, and in many cases fulfill a mechanical role in supporting physiologic loads that would otherwise be supported by a healthy tissue. In this review we will examine the development of scaffolds derived from biopolymers and their use with various cell types in the context of tissue engineering the nucleus pulposus of the intervertebral disc. [Pg.201]

Keywords Biomaterials Biopolymers Intervertebral disc Intervertebral disc degeneration Nucleus pulposus Tissue engineering... [Pg.201]

Nucleus Pulposus Replacement with Polymeric Materials ... [Pg.202]

Fig. 2 Representative histological images of (a) bovine annulus fibrosus (H E staining), (b) bovine nucleus pulposus (H E staining), and (c) porcine notochordal cells (Alcian blue staining for GAGs with fast red nuclei stain)...

Mwale F, Roughley P, Antoniou J (2004) Distinction between the extracellular matrix of the nucleus pulposus and hyaline cartilage a requisite for tissue engineering of intervertebral disc. Eur Cell Mater 8 58-63... [Pg.226]

Hunter CJ, Matyas JR, Duncan NA (2003) The notochordal cell in the nucleus pulposus a review in the context of tissue engineering. Tissue Eng 9(4) 667-677... [Pg.226]

Iatridis JC et al (1997) Alterations in the mechanical behavior of the human lumbar nucleus pulposus with degeneration and aging. J Orthop Res 15(2) 318—322... [Pg.227]

Johannessen W, Elliott DM (2005) Effects of degeneration on the biphasic material properties of human nucleus pulposus in confined compression. Spine (Phila Pa 1976) 30 (24) E724—E729... [Pg.227]

Vemengo J et al (2008) Evaluation of novel injectable hydrogels for nucleus pulposus replacement. J Biomed Mater Res B Appl Biomater 84(l) 64-69... [Pg.228]

Wardlaw D (2008) BioDisc nucleus pulposus replacement. In Yue J, Bertagnoli R, McAfee P, An H (eds) Motion preservation surgery of the spine advanced techniques and controversies. Elsevier, Philadelphia, pp 431—441... [Pg.228]

Joshi A et al (2006) Functional compressive mechanics of a PVA/PVP nucleus pulposus replacement. Biomaterials 27(2) 176-184... [Pg.228]

Boelen EJ et al (2005) Intrinsically radiopaque hydrogels for nucleus pulposus replacement. Biomaterials 26(33) 6674-6683... [Pg.228]

Halloran DO et al (2008) An injectable cross-linked scaffold for nucleus pulposus regeneration. Biomaterials 29(4) 438 147... [Pg.228]

Gorensek M et al (2004) Nucleus pulposus repair with cultured autologous elastic cartilage derived chondrocytes. Cell Mol Biol Lett 9(2) 363—373... [Pg.228]

Kaneyama S et al (2008) Fas ligand expression on human nucleus pulposus cells decreases with disc degeneration processes. J Orthop Sci 13(2) 130—135... [Pg.228]

Cappello R et al (2006) Notochordal cell produce and assemble extracellular matrix in a distinct manner, which may be responsible for the maintenance of healthy nucleus pulposus. Spine (Phila Pa 1976) 31(8) 873—882, discussion 883... [Pg.228]

Erwin WM et al (2006) Nucleus pulposus notochord cells secrete connective tissue growth factor and up-regulate proteoglycan expression by intervertebral disc chondrocytes. Arthritis Rheum 54(12) 3859-3867... [Pg.228]

Aguiar DJ, Johnson SL, Oegema TR (1999) Notochordal cells interact with nucleus pulposus cells regulation of proteoglycan synthesis. Exp Cell Res 246( 1) 129—137... [Pg.229]

Korecki CL et al (2010) Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation toward a young nucleus pulposus phenotype. Stem Cell Res Ther 1(2) 18... [Pg.229]

Risbud M, Izzo M, Adams C et al. (2003) Mesenchymal stem cells respond to their microenvironment and in vitro to assume nucleus pulposus-like phenotype. Paper presented at 30th Annual Meeting of the International Society for the Study of the Lumbar Spine. Vancouver, Canada... [Pg.229]

Li X et al (2005) Modulation of chondrocytic properties of fat-derived mesenchymal cells in co-cultures with nucleus pulposus. Connect Tissue Res 46(2) 75-82... [Pg.229]

Lu ZF et al (2007) Differentiation of adipose stem cells by nucleus pulposus cells configuration effect. Biochem Biophys Res Commun 359(4) 991-996... [Pg.229]

Tsai TT et al (2007) Fibroblast growth factor-2 maintains the differentiation potential of nucleus pulposus cells in vitro implications for cell-based transplantation therapy. Spine (Phila Pa 1976) 32(5) 495-502... [Pg.229]

Yang SH et al (2005) An in-vitro study on regeneration of human nucleus pulposus by using gelatin/chondroitin-6-sulfate/hyaluronan tri-copolymer scaffold. Artif Organs 29(10) 806-814... [Pg.229]

Yang SH et al (2005) Gelatin/chondroitin-6-sulfate copolymer scaffold for culturing human nucleus pulposus cells in vitro with production of extracellular matrix. J Biomed Mater Res B Appl Biomater 74(l) 488 f94... [Pg.229]

Li CQ et al (2009) Construction of collagen II/hyaluronate/chondroitin-6-sulfate tri-copoly-mer scaffold for nucleus pulposus tissue engineering and preliminary analysis of its physicochemical properties and biocompatibility. J Mater Sci Mater Med 21 741-751... [Pg.229]

Sakai D et al (2006) Atelocollagen for culture of human nucleus pulposus cells forming nucleus pulposus-like tissue in vitro influence on the proliferation and proteoglycan production of HNPSV-1 cells. Biomaterials 27(3) 346-353... [Pg.230]

Mercuri J, Gill S, Simionescu D (2011) Novel tissue derived biomimetic scaffold for regenerating the human nucleus pulposus. J Biomed Mater Res A 96(2) 422 135... [Pg.230]

Cloyd JM et al (2007) Material properties in unconfined compression of human nucleus pulposus, injectable hyaluronic acid-based hydrogels and tissue engineering scaffolds. Eur Spine J 16(11) 1892-1898... [Pg.230]

Seguin CA et al (2004) Tissue engineered nucleus pulposus tissue formed on a porous calcium polyphosphate substrate. Spine (Phila Pa 1976) 29(12) 1299-1306... [Pg.230]

Chou Al, Nicoll SB (2009) Characterization of photocrosslinked alginate hydrogels for nucleus pulposus cell encapsulation. J Biomed Mater Res A 91(1) 187-194... [Pg.230]

Chou Al, Akintoye SO, Nicoll SB (2009) Photo-crosslinked alginate hydrogels support enhanced matrix accumulation by nucleus pulposus cells in vivo. Osteoarthr Cartil 17(10) 1377-1384... [Pg.230]

Roughley P et al (2006) The potential of chitosan-based gels containing intervertebral disc cells for nucleus pulposus supplementation. Biomaterials 27(3) 388-396... [Pg.230]

Reza AT, Nicoll SB (2009) Characterization of novel photocrosslinked carboxymethyl-cellulose hydrogels for encapsulation of nucleus pulposus cells. Acta Biomater 6(1) 179-186... [Pg.230]

Yang SH et al (2008) Three-dimensional culture of human nucleus pulposus cells in fibrin clot comparisons on cellular proliferation and matrix synthesis with cells in alginate. Artif Organs 32(l) 70-73... [Pg.230]

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