SCID mice

Peled A, Kollet O, Ponomaryov T, et al. The chemokine SDF-1 activates the inte-grins LFA-1, VLA-4, and VLA-5 on immature human CD34(+) cells role in transendothelial/stromal migration and engraftment of NOD/SCID mice. Blood 2000 95( 11) 3289-3296. 

Blades MC, Ingegnoli F, Wheller SK, et al. Stromal cell-derived factor 1 (CXCL12) induces monocyte migration into human synovium transplanted onto SCID Mice. Arthritis Rheum 2002 46(3) 824-836. 

Lapenta C, Spada M, Santini SM, et al. Pertussis toxin B-oligomer inhibits HIV infection and replication in hu-PBL-SCID mice. Int Immunol 2005 17(4) 469-475. 

Arenberg DA, Kunkel SL, Polverini PJ, Glass M, Burdick MD, Stricter RM. Inhibition of interleukin-8 reduces tumorigenesis of human non-small cell lung cancer in SCID mice. J Clin Invest 1996 97(12) 2792-2802. 

Beider K, Nagler A, Wald O, et al. Involvement of CXCR4 and IL-2 in the homing and retention of human NK and NK T cells to the bone marrow and spleen of NOD/SCID mice. Blood 2003 102(6) 1951-1958. 

No No Yes Yes—in SCID mice Liver, kidney, lung, spleen, adrenal, lymph nodes, diaphragm... 

It is clear from studies in the 7. muris, H. polygyrus and N. brasiliensis systems that administration of IL-4C to infected SCID mice can mediate... 

In contrast with other enteropathies, there is no evidence that IFN-y plays an important role in either protection or pathology in T. spiralis infections. Infections in mice treated with anti-IFN-y antibody or in IFN-yR-deficient mice (Rose et al., 1994 Lawrence et al., 1998) were comparable in time course and pathology to those in controls. However, crypt hyperplasia was reduced following immunodepletion of IFN-y in SCID mice infected... 

Systemic targeting of pDNA and siRNA polyplexes has been demonstrated in several animal models. In continuation of the work with localized antiproliferative and immunostimulatory poly(I C) RNA, intravenous systemic delivery of EGER-targeted PEG-modified polyplexes were successfully used for human carcinoma treatment in mice [225]. The therapeutic effect was most pronounced when intravenous delivery of poly(I C) polyplexes was followed by intraperitoneal injection of peripheral blood mononuclear cells [226]. This induced the complete cure of SCID mice with pre-established disseminated EGFR-overexpressing tumors, without adverse toxic effects. Due to the chemokines produced by the internalized poly (I C) in the tumor cells, the immune cells home to the tumors of the treated animal and contribute to the tumor destruction. 

Seydel KB, Zhang T, Champion GA, Fichten-baum C, Swanson PE, Tzipori S, Griffiths JK, Stanley SL Jr Cryptosporidium parvum infection of human intestinal xenograils in SCID mice induces production of human tumor necrosis factor alpha and interleukin-8. Infect Immun 1998 66 2379-2382. 

Human immunodeficiency virus (HIV) type 1 ELDKWA epitope Potato virus X in tobacco leaf Sera from normal and hu-PBL-SCID mice showed anti-HIV-1 neutralizing activity. Immunogenic in mice when delivered parenterally or nasally. 18... 

Metastatic bone disease (MBD) is characterized by very high levels of bone turnover in regions proximal to the tumour [33]. Bone resorption inhibitors such as bisphosphonates represent the current standard of care for the treatment of bone metastases primarily due to breast or prostate cancer and multiple myeloma. It has been proposed that other strong anti-resorptives such as a Cat K inhibitor could be useful in the treatment of bone metastases. Evidence for this has been presented in the form of a preclinical MBD model in which human breast cancer cells are implanted into nude mice. Treatment with a Cat K inhibitor gave a significantly lower area of breast cancer-mediated osteolytic lesions in the tibia [34]. In a separate study, the efficacy of a Cat K inhibitor in the reduction in tumour-induced osteolysis was found to be enhanced in the presence of the bisphosphonate zolendronic acid [35,36]. When prostate cancer cells were injected into the tibia of SCID mice, treatment with a Cat K inhibitor both prevented and diminished the progression of cancer growth in bone [37]. 

Recently, it has been possible to grow cells of the human immune system in special mice. These mice carry a genetic defect called severe combined immunodeficiency (SCID), which leaves them with crippled immune systems, much like those in AIDS patients. Because SCID mice lack functional cellular immunity, it is possible to implant them with human cells without tissue rejection taking place. Researchers have recently developed techniques to implant human fetal tissues containing stem cells for the blood into SCID mice. It is then possible to reconstitute these mice with functional human immune system cells, including T lymphocytes and B lymphocytes. They have also found that if these SCID mice are infected by HIV, the virus will establish infection in the human tissue and destroy the T helper lymphocytes, just as it does in humans. Thus, it may be possible to study some of the mechanisms by which HIV attacks the immune system in these mice. In addition, they may be very useful for testing potential antiviral drugs. 

Millar JL, Millar BC, Powles RL, et al. Liposomal vincristine for the treatment of human acute lymphoblastic leukaemia in severe combined immunodelicient (SCID) mice. Br J Haematol 1998 102 718. 

Mazurier F, Doedens M, Gan 01, Dick JE. Rapid myeloeiythroid repopulation after intrafemoral transplantation of NOD-SCID mice reveals a new class of human stem cells. Nat Med. 2003 9 959-963. 

Hogan CJ, Shpall EJ, Keller G. Differential long-term and multilineage engraftment potential from subfractions of human CD34-F cord blood cells transplanted into NOD/SCID mice. Proc Natl Acad Sci USA. 2002 99 413-418. 

Angelopoulou M, Novell E, Grove JE et al. Cotransplantation of human mesenchymal stem cells enhances himian myelopoiesis and megakaryoc34opoiesis in NOD/SCID mice. Exp Hematol. 2003 31 413 420. 

Basecke, J., Schwieger, M., Griesinger, F., Schiedlmeier, B., Wulf, G., Tmmper, L. and Stocking, C. (2005) AMLl/ETO promotes the maintenance of early hematopoietic progenitors in NOD/SCID mice but does not abrogate their lineage specific differentiation. Leuk Lymphoma 46, 265 272. 

Lapidot, T., Pflumio, F., Doedens, M., Murdoch, B., Williams, D. and Dick J. (1992) Cytokine stimulation of multi lineage hematopoiesis from immature human cells engrafted in SCID mice, Science255, 1137-1141. 

The in vitro invasive assay consisted of grafting rat tracheas by implanting into severe combined immxmodeficiency disease (SCID) mice. The tracheas were first injected with the adenocarcinoma cells to promote tumor growth. Invasiveness was determined by histochemical staining of the iso-... 

SCID mice, severe combined immunodeficient mice... 

M. Q. Huang, D. S. Nelson, S. Pickup, H. Qiao, E. J. DeUkatny, H. Poptani and J. D. Glickson, In vivo monitoring response to chemotherapy of human diffuse large B-cell lymphoma xenografts in SCID mice by H and P MRS. Acad. Radiol., 2007,14, 1531-1539. 

The importance of lymphocytes in cancer treatments based on LPS had been evoked by Parr et al. [61], Their role was later emphasized in A/J mice bearing SA-1 sarcoma or BALB/c mice bearing Meth A fibrosarcoma, treated with LPS [95], and in BDEX rats bearing PROb colon carcinoma, treated with bacterial extracts [96], Furthermore, SCID mice treated with intraperitoneal (i.p.) injections of LPS are unable to reject Meth A fibrosarcoma [96], However, lipid A treatment was efficient in nude mice bearing human pancreatic tumors [134]. 

There were no signs of tumor formation at one year post-injection of HuCNS-SCs (105 or 106 cells) in NOD/SCID mice [437290]. No further data are currently available on the toxicity of HuCNS-SCs in animal models. 

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