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Scaffolds mesenchymal stem cells

Stem cell-scaffold systems Hyaluronan-based 3D scaffolds Mesenchymal stem cells Osteochondral repair Radice et al., 2000... [Pg.375]

Neuss and coworkers have reported the possibility of SMPs using PCL dimethacrylate copolymers as cellular scaffold for tissue engineering. Behaviors of different cells from three different species (human mesenchymal stem cells, human mesothelial cells, and rat mesothelial cells) on the matrices were investigated, and the differentiation capacity of mesenchymal stem cells on the matrices was also analyzed [329]. The SMPs proved biocompatibility for all tested cell types, supporting viability and proliferation. The SMPs also supported the osteogenic and adipogenic differentiation of human mesenchymal stem cells 3 weeks after induction. [Pg.105]

In an attempt to mimic the physiological ratio of collagen type II to hyaluronan in the healthy human NP, Calderon et al. constructed hydrogels scaffolds composed of these two elements in a 9 1 (w/w) ratio [104]. Scaffolds were crosslinked with various concentrations of EDC/NHS, but it was found that 8 mM EDC/NHS resulted in a confined compressive modulus on the order of the native NP, while allowing for optimal rat mesenchymal stem cell (rMSC) viability and proliferation. Additionally, real time PCR results from rMSCs seeded on the scaffolds for 21 days indicated that the scaffolds promoted increased aggrecan expression and inhibited collagen type I expression compared to rMSCs cultured on monolayers. [Pg.215]

BC is a good material not only for wound treatment and other fields of veterinary medicine, but also as a scaffold material for cell cultivation in tissue engineering [156,157]. On such scaffolds the fzmb has cultivated the following cell types successfully human osteoblasts, human osteogenic sarcoma cells (SAOS-2), equine osteoblast lines and chondrocytes, and mesenchymal stem cells. [Pg.84]

Meinel, L., Hofmann, S., Karageorgiou, V., Zichner, L., Langer, R., Kaplan, D., and Vunjak-Novakovic, G. "Engineering cartilage-like tissue using human mesenchymal stem cells and silk protein scaffolds". Biotechnol. Bioeng. 88(3), 379-391 (2004a). [Pg.154]

Wise JK et al (2009) Chondrogenic differentiation of human mesenchymal stem cells on oriented nanofibrous scaffolds engineering the superficial zone of articular cartilage. Tissue Eng A 15(4) 913-921... [Pg.208]

Wollenweber, M. Domaschke, H. Hanke, T. Boxbetger, S. Schmack, G. GUesche, K. Schamweber, D. Worch, H. Mimicked bioartificial matrix containing chondroitin sulphate on a textile scaffold of poly(3-hydroxybutyrate) alters the differentiation of adult human mesenchymal stem cells. Tissue Eng. 2006 February, 12(2), 345-359. [Pg.41]

Mota, A., A.S. Lotfi, J. Barzin, M. Hatam, B. Adibi, Z. Khalaj, and M. Massumi. Human bone marrow mesenchymal stem cell behaviors on PCL/gelatin nanofibrous scaffolds modified with A collagen IV-derived RGD-containing peptide. Cell Journal (Yakhteh) 16(1) (2014) 1. [Pg.435]

Chastain, S. R., Kundu, A. K., Dhar, S., Calvert, J. W, Putnam, A. J. Adhesion of mesenchymal stem cells to polymer scaffolds occurs via distinct ECM ligands and controls their osteogenic differentiation. Journal of Biomedical Materials Research. 2006, 78, 73-85. [Pg.931]

Kim, H., Kim, H. W, Suh, H. Sustained release of ascorbate-2-phosphate and dexamethasone from porous PLGA scaffolds for bone tissue engineering using mesenchymal stem cells. Biomaterials. 2003, 24, 4671-4679. [Pg.931]

Li, W. Tuli, R. Okafor, C. Derfoul, A. Danielson, K.G. Hall, D.J. Tuan, R.S. A three-dimensional nanofibrous scaffold for cartilage tissue engineering using human mesenchymal stem cells. Biomaterials 2005, 26 (6), 599-609. [Pg.1330]

Shin M, Yoshimoto H, Vacanti JP (2004) In vivo bone tissue engineering using mesenchymal stem cells on a novel electrospun nanofibrous scaffold. Tissue Eng 10 33-41 Shinomiya M, Iwata T, Doi Y (1998) The adsorption of substrate-binding domain of PHB depolymerases to the surface of poly(3-hydroxybutyric acid). Int J Biol Macromol 22 129-135 Sim YC, Sudesh K (Unpublished). Annual report 2009 (2009) http //www.simedaiby.com/ downloads/pdfs/SDB/Annual Report/Sime Darby AR2009.pdf. Accessed online. Accessed Oct 1 2010... [Pg.124]

W. Bensaid, J. Triffitt, C. Blanchat, K. Oudina, L. Sedel, H. Petite, A biodegradable fibrin scaffold for mesenchymal stem cell transplantation, Biomaterials 24 (2003) 2497-2502. [Pg.56]

H.B. Fan, H.F. Liu, S.L. Toh, J.C.H. Goh, Anterior cruciate liga- [185] ment regeneration using mesenchymal stem cells and silk scaffold... [Pg.60]

J.R. Mauney, et al.. Engineering adipose-Uke tissue in vitro and in vivo utilizing human bone marrow and adipose-derived mesenchymal stem cells with silk fibroin 3D scaffolds, Biomaterials 28 (2007) 5280-5290. [Pg.240]

S. Neuss, et al.. Long-term survival and bipotent terminal differentiation of human mesenchymal stem cells (hMSC) in combination with a commercially available three-dimensional collagen scaffold. Cell Transplant. 17 (2008) 977-986. [Pg.240]

L. Zhao, M. Tang, M.D. Weir, M.S. Detamore, H.H. Xu, Osteogenic media and rhBMP-2-induced differentiation of umbilical cord mesenchymal stem cells encapsulated in alginate microbeads and integrated in an injectable calcium phosphate-chitosan fibrous scaffold. Tissue Eng. A 17 (7-8) (2010) 969-979. [Pg.368]

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