Gene delivery mesenchymal stem cells

Deng Y, Guo X, Yuan Q, Li S. Efficiency of adenoviral vector mediated CTLA4Ig gene delivery into mesenchymal stem cells. Chin Med J (Engl) 2003 116 1649-1654. 

Saraf A, Hacker MC, Sitharaman B et al (2008) Synthesis and conformational evaluation of a novel gene delivery vector for human mesenchymal stem cells. Biomacromolecules 9 (3) 818-827... 

Another novel cardiovascular therapy that has recently come into play is the use of stem cell delivery. These approaches have thus far involved the use of gene delivery mechanisms to essentially force embryonic stem cells into cardiomyocyte differentiation with the goal of producing a cardiac pace-making cell (Arruda et al., 2004). Researchers are also developing methods for utilizing seeded adult mesenchymal stem cells as an implanted base to act as a depot for the delivery of localized gene therapies (Arruda et al., 2004). 

Meinel, L., Hofmann, S., Betz, O., Fajardo, R., Merkle, H.P., Langer, R., Evans, C.H., Vunjak-Novakovic, G., and Kaplan, D.L. "Osteogenesis by human mesenchymal stem cells cultured on silk biomaterials Comparison of adenovirus mediated gene transfer and protein delivery of BMP-2". Biomaterials 27(28), 4993-5002 (2006b). 

L. R. Ee, Nanostructured PEG-based hydrogels with tunable physical properties for gene delivery to human mesenchymal stem cells. Biomaterials 33 (2012) 6533-6541. 

Cationic Polymers for Gene Delivery into Mesenchymal Stem Cells as a Novel Approach to Regenerative Medicine... 

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