Intervertebral disc degeneration

Advances in Tissue Engineering Approaches to Treatment of Intervertebral Disc Degeneration Cells and Polymeric Scaffolds for Nucleus Pulposus Regeneration... [Pg.201]

Keywords Biomaterials Biopolymers Intervertebral disc Intervertebral disc degeneration Nucleus pulposus Tissue engineering... [Pg.201]

T able 2 Summary of the matrix metalloproteinases involved in intervertebral disc degeneration [26,41]... [Pg.207]

Le Maitre CL et al (2007) Matrix synthesis and degradation in human intervertebral disc degeneration. Biochem Soc Trans 35(Pt 4) 652-655... [Pg.226]

Rutges JP et al (2008) Increased MMP-2 activity during intervertebral disc degeneration is correlated to MMP-14 levels. J Pathol 214(4) 523-530... [Pg.226]

Walker MH, Anderson DG (2004) Molecular basis of intervertebral disc degeneration. Spine J 4(6 Suppl) 158S-166S... [Pg.226]

Goupille P et al (1998) Matrix metalloproteinases the clue to intervertebral disc degeneration Spine (Phila Pa 1976) 23( 14) 1612—1626... [Pg.227]

Sobajima S et al (2008) Feasibility of a stem cell therapy for intervertebral disc degeneration. Spine J 8(6) 888-896... [Pg.229]

Nomura T et al (2001) Nucleus pulposus allograft retards intervertebral disc degeneration. Clin Orthop Relat Res 389 94-101... [Pg.232]

Nuckley DJ et al (2008) Intervertebral disc degeneration in a naturally occurring primate model radiographic and biomechanical evidence. J Orthop Res 26(9) 1283-1288... [Pg.232]

Sobajima S et al (2005) A slowly progressive and reproducible animal model of intervertebral disc degeneration characterized by MRI, X-ray, and histology. Spine 30(l) 15-24... [Pg.232]

Kroeber MW et al (2002) New in vivo animal model to create intervertebral disc degeneration and to investigate the effects of therapeutic strategies to stimulate disc regeneration. [Pg.232]

Hoogendoom RJ et al (2007) Experimental intervertebral disc degeneration induced by chondroitinase ABC in the goat. Spine (Phila Pa 1976) 32(17) 1816-1825... [Pg.232]

Low back pain is the leading cause of job-related disability in the United States and second only to headache as the most common neurologic complaint [11]. The causes are many, but degeneration of the spine and intervertebral discs are frequently blamed. Conventional scientific consensus says intervertebral disc degeneration and other spinal abnormalities are largely mechanical, but recent evidence has implicated genetic and biochemical... [Pg.86]

Jim JJ, Noponen-Hietala N, Cheung KM, et al. The TRP2 allele of COL9A2 is an age-dependent risk factor for the development and severity of intervertebral disc degeneration. Spine 2005 30(24) 2735 2. [Pg.93]

In terms of medical applications, DSC has been used to examine intervertebral disc degeneration in humans . The results suggested that definitive differences exist between the stages of disc degeneration in calorimetric measures. [Pg.169]

Le Maitre CL, Freemont AJ, Hoyland JA. The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration. Arthritis Res Ther 2005 7 R732-R745. [Pg.149]

Cs-Szabo G, Ragasa-San Juan D, Turumella V, Masuda K, Thonar EJ, An HS. Changes in mRNA and protein levels of proteoglycans of the anulus fibrosus and nucleus pulposus during intervertebral disc degeneration. Spine 2002 27 2212-2219. [Pg.153]

Bertram H, Steck E, Zimmermann G, Chen BH, Carstens C, Nerlich A, Richter W. Accelerated intervertebral disc degeneration in scoliosis versus physiological ageing develops against a background of enhanced anabolic gene expression. Biochem Biophys Res Commun 2006 342 963-972. [Pg.153]

Recent Advances in Regenerative Approaches to Intervertebral Disc Degeneration... [Pg.427]

Sakai, D., Anderson, G.B.J. Stem cell therapy for intervertebral disc regeneration obstacles and solution. Nat. Rev. Rheumatol. (2015). doi 10.1038/nirheum.2015.13 Maidhof, R., Alipui, D.O., Rafiuddin, A., Levine, M., Grande, D.A., Chahine, N.O. Emerging trends in biological therapy for intervertebral disc degeneration. Discov. Med. 14, 401 11 (2012)... [Pg.439]

Liu, Y., Fu, S., Rahaman, M.N., Mao, J.J., Bal, B.S. Native nucleus pulposus tissue matrix promotes notochordal differentiation of human induced pluripotent stem cells with potential for treating intervertebral disc degeneration. J. Biomed. Mater. Res. A (2014). doi 10.1002/jbm.a.35243... [Pg.442]

Adams MA, Roughley PJ (2006) What is intervertebral disc degeneration, and what causes it Spine 31 2151-2161... [Pg.320]

Lyons, G., Eisenstein, S.M. and Sweet, M.B.E. (1981) Biochemical changes in intervertebral disc degeneration. Biophysics Acta, 673, 443. [Pg.57]

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