Ciprofloxacin hydrochloride and

Ciprofloxacin hydrochloride and hydrocortisone otic suspension contains the synthetic broad spectrum antibacterial agent, ciprofloxacin hydrochloride, combined with the anti-inflammatory corticosteroid, hydrocortisone, in a preserved, nonsterile suspension for otic use. Each milliliter contains ciprofloxacin hydrochloride (equivalent to 2 mg... 

Nijhawan and Agarwal [140] investigated inclusion complexes of ciprofloxacin hydrochloride and hydroxy-propyl-P-cyclodextrin and found that the complexes exhibited better stability, biological activity, and ocular tolerance than the uncom-plexed drug in solution. 

Mao ZW, Ma L, Gao CY, Shen JC. Preformed microcapsules for loading and sustained release of ciprofloxacin hydrochloride. J Controlled Release 2005 104 193-202. 

Warfarin sodium may be adsorbed to PVC and intravenous infusion sets but may be minimized with glass containers or polyethylene-lined containers. Warfarin sodium is incompatible with solutions of adrenaline hydrochloride, amikacin sulfate, metaraminol tartrate, oxytocin, promazine hydrochloride, tetracycline hydrochloride, aminophylline, bretylium tosylate, ceftazidime, cimetidine hydrochloride, ciprofloxacin lactate, dobutamine hydrochloride, esmolol hydrochloride, gentamicin sulfate, labetalol hydrochloride, metronidazole hydrochloride, and vancomycin hydrochloride.130131... 

The assay of an IV formulation is performed using a liquid chromatographic method, which requires the following solutions. For solution (1), dilute a quantity of the intravenous infusion with sufficient mobile phase to produce a solution containing the equivalent of 0.05% w/v of ciprofloxacin. Solution (2) contains 0.058% w/v of ciprofloxacin hydrochloride EPCRS in mobile phase. Solution (3) contains 0.025% w/v of ciprofloxacin impurity C EPCRS (ethylenediamine compound) in solution (2). For solution (4), dilute 1 volume of solution (3) to 100 volumes with the mobile phase. The chromatographic procedure may be carried out using a stainless steel column (12.5 cm x 4 mm) packed with stationary phase C (5 mm) (Nucleosil C18 is suitable). The mobile phase is eluted at a flow rate of 1.5 mL/min, and consists of a mixture of 13 volumes of acetonitrile and 87 volumes of a 0.245% w/v solution of orthophosphoric acid (the pH of which has been adjusted to 3.0 with triethylamine). Analytes are detected on the basis of their UV absorption at 278 nm. The assay is not valid unless in the chromatogram obtained with solution (3), the resolution factor between the peaks due to ciprofloxacin and the ciprofloxacin impurity C is at least 1.5. 

Ciprofloxacin hydrochloride, in pharmaceutical raw material and capsules, has been analyzed by oscillopolarography [21]. A sample that was mixed with 2 mL of 0.5 M KH2P04/K0H buffer (pH 6.9), and diluted with water, yielded a reductive peak potential at —1.51 V vs. SCE. The calibration graph was linear from 0.1 to 20 pM, with an average recovery of 101.1% and a RSD of 1.14%. 

Charoo, N. A., Kohli, K., Ali, A., and Anwer, A. (2003), Ophthalmic delivery of ciprofloxacin hydrochloride from different polymer formulations In vitro and in vivo studies, Drug Dev. Ind. Pharm., 29(2), 215-221. 

The ciprofloxacin hydrochloride ophthalmic ointment consists of synthetic, sterile, multiple-dose, antimicrobials for topical ophthalmic use. Ciprofloxacin is a fluoroquinolone antibacterial that is active against a broad spectrum of gram-positive and gram-negative ocular pathogens. It is available as the monohydrochloride monohydrate salt of 1-cyclopropyl-6-fluoro-l,4-dihydro-4-oxo-7-(l-piperazinyl)-3-quinoline-carboxylic acid. It is a faint to light-yellow... 

Films of alginate and gelatin, cross-linked with Cs and containing ciprofloxacin hydrochloride as model drug in different concentrations, were obtained by a casting/solvent evaporation method. The film can lead to a successful application for localized dmg delivery in vivo or in vitro environments [135]. 

Ciprofloxacin recently received much press because it was the drug of choice for combating anthrax. Ciprofloxacin hydrochloride, Cj HjgFNjOj-HCbH O, is a synthetic broad-spectrum antibacterial agent. Ciprofloxacin differs from other quinolones in that it has a fluorine atom at the 6-position, a piperazine moiety at the 7-position, and a cyclopropyl ring at the 1-position. 

Liposomes Ciprofloxacin Hydrochloride Improved ocular permeation, prolonged drug release and enhanced antibacterial activity of ciprofloxacin [90]... 

Tuncel, T., and Bergisadi, N., 1992, In Vitro Adsorption of Ciprofloxacin Hydrochloride on Various Antacids , Pharmazie, 47, pp 304-305. 

Semi interpenetrating polymer networks pPNs) of carboxymethyl cellulose (CMC) and polyacrylic acid were prepared by Bajpai et. al. [130] and its potential for controlled release of ciprofloxacin were assessed. The IPNs were characterized by IR spectral analysis and ESEM analysis. The entrapped drug was examined for its antibacterial activity and chemical stability. The effects of experimental parameters such as vaiying chemical composition of the IPNs, % loading of Cfe (ciprofloxacin) hydrochloride, pH, and temperature of release medium and presence of salts ions in outer solution were examined on the release profile of the drug. 

Heparin and its salts are incompatible with many drugs including alteplase, amikacin sulfate, amiodarone hydrochloride, ampicillin sodium, aprotinin, benzylpenicillin potassium or sodium, cephalothin sodium, ciprofloxacin lactate, cytarabine, dacarbazine, daunorubicin hydrochloride, diazepam, dobutamine hydrochloride, doxorubicin hydrochloride, droperidol, erythromycin lactobionate, gentamicin sulfate, haloperidol lactate, hyaluronidase, hydrocortisone sodium succinate, kanamycin sulfate, methicillin sodium, netilmicin sulfate, some opioid analgesics, oxytetracycline hydrochloride, some phenothiazines, polymyxin B sulfate, streptomycin sulfate, tetracycline hydrochloride, tobramycin sulfate, vancomycin hydrochloride, vinblastine sulfate, cisatracurium besylate, labetalol hydrochloride, nicardipine hydrochloride, cefmetazole, sodium ions, and fat emulsion.110 112... 

Holtzapple et al. developed an immunoassay method for determination of four fluoroquinolone compounds (including ciprofloxacin) in liver extracts [64]. In this method, an immunoaffinity capture SPE column was used, that contained anti-sarafloxacin antibodies covalently cross-linked to protein G. After interfering liver matrix compounds had been washed away, the bound ciprofloxacin was eluted directly onto the HPLC column. The HPLC system used a 5 pm Inertsil phenyl column (15 cm x 4.6 mm i.d.), with 0.1 M-glycine hydrochloride/acetonitrile (17 3) as the mobile phase (eluted at a rate of 0.7 mL/min). Fluorimetric detection at 444 nm was used after excitation at 280 nm. The recovery of ciprofloxacin ranged from 85.7 to 93.5%, and the detection limit was... 

Ciprofloxacin is commercially available as the monohydrate phase of its hydrochloride salt, and has been formulated for oral and ophthalmic administration. The compound has also been developed as the lactate salt for use in intravenous administration [3]. 

Seven paralytic shellfish toxins (PSTs), namely decarbamoylsaxitoxin (dcSTX), saxitoxin (STX), neosaxitoxin (NEO), gonyautoxin-2 (GTX-2), gonyautoxin-3 (GIX-3), gonyautoxin-1 (GTX-1), and gonyautoxin-4 (GTX-4) Antibiotics residues (amoxicillin, doxycycline hydrochloride, streptomycin sulfate, thiamphenicol, florphenicol, nifursol, enrofloxacin, ciprofloxacin, norfloxacin) from poultry and porcine tissues Quinolones [enrofloxacin (ENR), ciprofloxacin (CPR), danofloxacin (DAN), difloxacin (DIF), marbofloxacin (MAR), flumequine (FLU), and oxolinic acid (OXA)] in pig kidney tissue... 

The determination of amoxicilline, ciprofloxacin, and piroxicam in bulk and pharmaceutical preparations has been performed by combining the oxidation character of Fe(III) with the chelation property of Fe(II), affording highly colored complexes. The reagent solutions are (1) a mixture of 1,10-phenanthroline and iron(III) ammonium sulfate in hydrochloride medium and (2) 2,2 -bipyridyl and iron(III) ammonium sulfate in hydrochloride medium. The resulting Fe(II) concentration, proportional to the amount of drug present, is monitored by the measurement of absorbances of tris(o-phenanthro-line) iron(U) or tris (bipyridyl) iron(II) complexes at 510 and 522 nm, respectively. 

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