Esmolol hydrochloride

Esmolol. Esmolol hydrochloride, an ultrashort acting cardioselective P ceptor blocker having no ISA or membrane stabilizing activity, is... 

Esmolol hydrochloride 250-500 mcg/kg/minute IV bolus, then 50-100 mcg/kg/minute by infusion may repeat bolus after 5 minutes or increase infusion to 300 mcg/minute 1-2 minutes 10-30 minutes Hypotension, nausea, asthma, first-degree heart block, heart failure Aortic dissection, perioperative... 

Esmolol hydrochloride is a competitive p-adrenergic receptor antagonist it is selective for pT adrenoceptors. In contrast to pindolol, esmolol has little intrinsic sympathomimetic activity, and it differs from propranolol in that it lacks membrane stabilizing activity Of all of the p-adrenergic blocking drugs, this compound has the shortest duration of action because it is an ester, it is hydrolyzed rapidly by plasma esterases and must be used by the intravenous route Esmolol is approved only for the treatment of supraventricular arrhythmias... 

Class n, beta-adrenergic blocking agents esmolol hydrochloride propranolol hydrochloride sotalol hydrochloride... 

Warfarin sodium may be adsorbed to PVC and intravenous infusion sets but may be minimized with glass containers or polyethylene-lined containers. Warfarin sodium is incompatible with solutions of adrenaline hydrochloride, amikacin sulfate, metaraminol tartrate, oxytocin, promazine hydrochloride, tetracycline hydrochloride, aminophylline, bretylium tosylate, ceftazidime, cimetidine hydrochloride, ciprofloxacin lactate, dobutamine hydrochloride, esmolol hydrochloride, gentamicin sulfate, labetalol hydrochloride, metronidazole hydrochloride, and vancomycin hydrochloride.130131... 

In the clinic, esmolol s distribution half-life is 2 min and its elimination half-life is 9 min. Esmolol hydrochloride is rapidly metabolized by hydrolysis of the ester linkage, chiefly by esterases in the cytosol of red blood cells and not by plasma cholinesterases or red cell membrane acetylcholinesterase [22]. Its volume of distribution is 3.4 L kg-1, and its total clearance is 285 mL kg-1 min-1, "... which is greater than cardiac output thus the metabolism ofesmolol is not limited by the rate of blood flow to metabolizing tissues such as the liver or affected by hepatic or renal blood flout [22]. As expected from such a "... high rate of blood-based metabolism, less than 2% of the drug is excreted unchanged in the wind [22]. Within 24 h after infusion, approximately... 

Quote and details taken directly from package insert as provided by Bedford Laboratories for Esmolol Hydrochloride Injection ready-to-use 10 mLvials. ... 

Angaran DM, Schultz NJ, Tschida VH. Esmolol hydrochloride an ultrashort-acting, beta-adrenergic blocking agent. Clin Pharm 1986 5(4) 288-303. 

Esmeron rocuronium bromide, esmolol [BAN, inn] (esmolol hydrochloride [usan] Brevibloc Celectol ) is a P-adrenoceptor antagonist, which is relatively water-soluble. Therapeutically, it can be used as an antiarrhythmic to control supraventricular tachyarrhythmias, as an antihypertensive and antiglaucoma treatment. 

V. Dave, S. Sharma, and S. Pahwal, Design and evaluation of esmolol hydrochloride ocular inserts with specied reference to glaucoma treatment, /Pharm Invest, 43,89-99,2013. 

Esmolol hydrochloride concentrated intravenous infusion 250 mg/mL. Adult dose the infusion is diluted and administered at 0.05-0.2 mg/kg/min. 

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