Sodium succinate hydrocortisone

Administer hydrocortisone sodium phosphate or hydrocortisone sodium succinate, 100 mg intravenously every 6 to 8 hours for 24 hours. 

Anderson, J. M., Komis, T., Nelson, T., Horst, M., and Love, D. S., The Slow Release of Hydrocortisone Sodium Succinate from Poly(2-Hydroxyethyl Methacrylate) Membranes, in Hydrogels for Medical and Related Applications (J. D. Andrade, Ed.), American Chemical Society Washington, pp. 167-178. 1976. 

Admixture incompatibilities - Magnesium sulfate in solution may result in a precipitate formation when mixed with solutions containing Alcohol (in high concentrations) alkali carbonates and bicarbonates alkali hydroxides arsenates barium calcium clindamycin phosphate heavy metals hydrocortisone sodium succinate phosphates polymyxin B sulfate procaine hydrochloride salicylates strontium tartrates. 

Hydrocortisone sodium succinate - May be administered IV or IM. The initial dose is 100 to 500 mg, and may be repeated at 2-, 4- or 6-hour intervals depending on patient response and clinical condition. 

Incompatibilities Do not mix IV minocycline before or during administration with any solutions containing the following Adrenocorticotropic hormone (ACTH), aminophylline, amobarbital sodium, amphotericin B, bicarbonate infusion mixtures, calcium gluconate or chloride, carbenicillin, cephalothin sodium, cefazolin sodium, chloramphenicol succinate, colistin sulfate, heparin sodium, hydrocortisone sodium succinate, iodine sodium, methicillin sodium, novobiocin, penicillin, pentobarbital, phenytoin sodium, polymyxin, prochlorperazine, sodium ascorbate, sulfadiazine, sulfisoxazole, thiopental sodium, vitamin K (sodium bisulfate or sodium salt), whole blood. 

Hydrocortisone is a relatively short-acting agent. For replacement therapy in adrenal insufficiency it is administered orally and in combination with fludrocortisone. Hydrocortisone sodium succinate is a water-soluble derivative which can be used parenter-ally in emergencies such as acute bronchospasm and hypersensitivity reactions like anaphylactic shock. 

Hydrocortisone (Cortisol HYCOSON) 100 mg IM used as hydrocortisone sodium succinate injection. Also used as intraarticular inj. as hydrocortisone acetate 1-2.5% topical (skin, ear eye WYCORT)... 

Hydrocortisone sodium succinate or phosphate in doses of 100 mg intravenously is given every 8 hours until the patient is stable. The dose is then gradually reduced, achieving maintenance dosage within 5 days. 

Parenteral 50 mg/mL for IV, IM, or SC injection Hydrocortisone sodium succinate (generic, SoluCortef)... 

During the infusion of amphotericin B, the patient s temperature will rise, which may or may not be accompanied by hypotension and delirium. Often, hydrocortisone sodium succinate is added to the infusion during the initial but not the succeeding alternate-day treatment with amphotericin B. 

Although sedative antihistamines do not potentiate the effect of alcohol, they should be avoided in excess quantity. Overdose of astemizole can be treated with gastric lavage and supportive measures.86 Coadministration of astemizole and ter-fenadine with antiarrhythmics, antipsychotics, cisapride, and diuretics should be avoided. Chlorpheniramine maleate has been found to be incompatible with phe-nobarbitone sodium, kanamycin sulfate, and calcium chloride. Cyclizines have been used alone or with opioids in tablets or in injectable form for euphoric effects. Cyproheptadine has shown dependence in long-term use. Diphenhydramine is reported to be incompatible with amphotericin, cephalothin sodium, and hydrocortisone sodium succinate. Diphenhydramine and pheniramine maleate are sometimes used as drugs of abuse. Studies have shown that promethazine is adsorbed onto glass, plastic containers, and infusion systems.87... 

Heparin and its salts are incompatible with many drugs including alteplase, amikacin sulfate, amiodarone hydrochloride, ampicillin sodium, aprotinin, benzylpenicillin potassium or sodium, cephalothin sodium, ciprofloxacin lactate, cytarabine, dacarbazine, daunorubicin hydrochloride, diazepam, dobutamine hydrochloride, doxorubicin hydrochloride, droperidol, erythromycin lactobionate, gentamicin sulfate, haloperidol lactate, hyaluronidase, hydrocortisone sodium succinate, kanamycin sulfate, methicillin sodium, netilmicin sulfate, some opioid analgesics, oxytetracycline hydrochloride, some phenothiazines, polymyxin B sulfate, streptomycin sulfate, tetracycline hydrochloride, tobramycin sulfate, vancomycin hydrochloride, vinblastine sulfate, cisatracurium besylate, labetalol hydrochloride, nicardipine hydrochloride, cefmetazole, sodium ions, and fat emulsion.110 112... 

Prochlorperazine Edisylate Prochlorperazine edisylate is not compatible with sodium chloride solutions containing methyl hydroxybenzoate and propyl hydroxy-benzoate as preservatives, but is compatible with solutions containing benzyl alcohol. Prochlorperazine edisylate salts are incompatible with a number of drugs such as aminophylline, amphotericin, ampicillin sodium, some barbiturates, ben-zylpenicillin salts, calcium gluconate, cefmetazole sodium, cephalothin sodium, chloramphenicol sodium succinate, chlorothiazide sodium, chloramphenicol, morphine sulfate containing phenol, magnesium trisilicate mixture, sodium succinate, chlorothiazide sodium, dimenhydrinate, heparin sodium, hydrocortisone sodium succinate, midazolam hydrochloride, and some sulfonamides.166... 

Bleomycin Bleomycin is incompatible and loses its potency if it is administered with solutions of benzylpenicillin sodium, carbenicillin, cephazolin or cephalothin sodium, hydrocortisone sodium succinate, mitomycin, methotrexate, nafcillin sodium, aminophylline, ascorbic acid, terbutaline, divalent and trivalent cations (especially copper), compounds containing sulfhydryl groups, and precipitation by hydrophobic anions, essential amino acids, riboflavine, dexamethasone, and frusemide. 

Precipitation occurs when doxorubicin is combined with diazepam or hydrocortisone sodium succinate and frusemide or heparin sodium. Visual incompatibility forms a purple color when doxorubicin is mixed with aminophylline.216 Doxorubicin is not photodegradable but is sensitive to light at low concentrations. 

II- p-HYDROCORTISONE see CNS750 HYDROCORTISONE FREE ALCOHOL see CNS750 HYDROCORTISONE SODIUM SUCCINATE see HHROOO... 

Parenteral preparation for systemic effect the soluble Hydrocortisone Sodium Succinate Inj. is used for quick (1-2 h) effect for continuous effect about 8-hourly administration is appropriate. Prednisolone Acetate Inj. i.m. is an alternative, once or twice a week. 

This is an emergency and hydrocortisone sodium succinate 100 mg should be given i.v. immediately it is suspected, or the patient may die. 

Hydrocortisone Sodium Phosphate R = POa (Na )j Hydrocortisone Sodium Succinate ... 

Preparations available are pellets containing hydrocortisone sodium succinate 2.5 mg, and a paste containing triamcinolone acetonide 0.1% in carmellose... 

Carboxylic half-esters (e.g. hemisuccinates) of phenols are easily hydrolyzed in aqueous solution and are therefore not recommended for the solubilization of phenolic compounds. Even hemisuccinates of alcohols suffer somewhat from stability problems and must be supplied as lyophi-lized (freeze-dried) powders for reconstitution in water and used within 48 h (see, for example, the monographies chloramphenicol sodium succinate or hydrocortisone sodium succinate in The Handbook on Injectable Drugs,see also Anderson et... 

A number of other agents may be required for the treatment of anaphylactic reactions. Corticosteroids (hydrocortisone sodium succinate intravenously) are recommended to reduce the risk of late-phase reactions. Aminophylline may be used as adjunctive therapy for bronchospasm. Histamine (Hi) receptor blockers (such as diphenhydramine) may be administered to reduce some of the symptoms associated with anaphylaxis however, these agents are not effective as primary therapy. 

Administer hydrocortisone sodium succinate 100 mg intravenously (push) and 100 mg intravenously in saline every 2-4 h to block the late-phase reaction. 

Cortisone (25 to 300 mg/day) is insoluble in water. Cortisone acetate (Biofine) is available in a 25-mg tablet. Hydrocortisone (cortisol, 20 to 240 mg/day) exists in suspension and is insoluble in water. Hydrocortisone cypionate (Cortef, 20 to 240 mg/day) is available in an oral suspension. Hydrocortisone sodium phosphate, a water-soluble salt with a rapid onset but short duration of action, is available for IV, IM, or SC injection. Hydrocortisone sodium succinate (Solu-Cortef) in an initial dose of 100 to 500 mg may be administered IV or IM. The antiinflammatory effect of corfisol is relatively weak (Table 11). 

Hydrocortisone and hydrocortisone cypionate (Cortef) may be administered orally. Hydrocortisone sodium phosphate may be administered by IM, SC, or IV injection, or by IV infusion, q. 12-hour interval. Hydrocortisone sodium succinate (A-hydroCort, Lifocort, Solu-Cortef) may be administered by IM or rV injection or IV infusion q. 2 to 10 hours, depending on the clinical situation. Hydrocortisone acetate is a suspension that may be administered by intra-articular, intrasynovial, intrabursal, intralesional, or soft tissue injection. It has a slow onset but a long duration of action. The injectable forms are usually used only when the oral dosage forms cannot be used (see also Table 11). 

HYDROCORTISONE SODIUM SUCCINATE (A-hydroCort, Efcortelan, Lifocort, Solu-Cortef)... 

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