Kanamycin sulfate

Chemical Name 0-3-amino-3-deoxy-O -D-glucopyranosyl-(1 glucopyranosyl- 1 r4)-2-deoxy-D-streptamine sulfate 

Trade Name Manufacturer Country Year Introduced 

As described in U.S. Patent 2,931,798, Streptomyces kanamyceticus (K2-J) was first cultured in shake flasks in the following media (a) 0.75% meat extract, 0.75% peptone, 

The yield was highest with starch or dextrin, intermediate and about the same with sucrose, glucose, maltose and lactose and poorest with glycerol. Kanamycin was produced by media containing soybean meal, peanut meal, cottonseed meal, corn steep liquor, peptone, yeast extract or meat extract, with or without sodium nitrate. Commercially available soybean meal was recognized to be one of the best nitrogen sources. The addition of corn steep liquor, peptone, yeast extract or nitrate to the soybean meal promoted the production of kanamycin. 

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The brownish white kanamycin (5 g) was dissolved in 50 ml of 60% aqueous methanol, insoluble material was removed and to the filtrate 40 ml of 60% aqueous methanol containing 2,000 mg of ammonium sulfate was added, and the precipitated kanamycin sulfate was collected, washed with 50 ml of 80% aqueous methanol, and dried. Thus. 4.5 g of kanamycin sulfate was obtained as a light brownish powder. 

Streptomyces kanamycetius Bekanamycin sulfate Kanamycin sulfate Streptomyces layendulae Cycloserine... 

Soybean meal, by fermentation Bacitracin Clavulanic acid Cycloserine Erythromycin Gentamicin sulfate Kanamycin sulfate Micronomicin Novobiocin Oleandomycin Oxamniquine Oxytetracycline Paromomycin Ribostamicin Sisomicin... 

Kanescin - Kanamycin sulfate Kano - Kanamycin sulfate Kantor - Minaprine Kantrex - Kanamycin sulfate Kapiride - Sulpiride Kapoxi - Amoxicillin Kappabi -Oibekacin... 

Isopropylamine [75-31-0] Kanamycin sulfate [133-92-6 25389-94-0]6 203 IB I(3)368A, N(1)242C NT8400000 NZ3225000, USP... 

Kaale, E., Van Schepdael, A., Roets, E., and Hoogmartens, J. (2001). Development and validation of a simple capillary zone electrophoresis method for the analysis of kanamycin sulfate with UV detection after pre-capillary derivatization. /. Chromatogr. A 924(1—2), 451—458. 

Materials for media (Bacto Tryptone, Bacto Yeast Extract and Difco SOB Medium, agar powder and NaCl) and antibiotics (ampicillin sodium and kanamycin sulfate). 

Although sedative antihistamines do not potentiate the effect of alcohol, they should be avoided in excess quantity. Overdose of astemizole can be treated with gastric lavage and supportive measures.86 Coadministration of astemizole and ter-fenadine with antiarrhythmics, antipsychotics, cisapride, and diuretics should be avoided. Chlorpheniramine maleate has been found to be incompatible with phe-nobarbitone sodium, kanamycin sulfate, and calcium chloride. Cyclizines have been used alone or with opioids in tablets or in injectable form for euphoric effects. Cyproheptadine has shown dependence in long-term use. Diphenhydramine is reported to be incompatible with amphotericin, cephalothin sodium, and hydrocortisone sodium succinate. Diphenhydramine and pheniramine maleate are sometimes used as drugs of abuse. Studies have shown that promethazine is adsorbed onto glass, plastic containers, and infusion systems.87... 

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