Streptomycin sulfate

Dihydrostreptomycin sulfate may be prepared from streptomycin sulfate by catalytic hydrogenation (Merck, Pfizer, Cyanamid), electrolytic reduction (Schenley, Olin Mathieson), or by sodium boro hydride reduction (Bristol), or by isolation from a fermentation process (Takeda). 

Banyu Dainippon Kaken Kyowa Meiji Nikken Sankyo Sanwa Taito Pfizer Takeda Toyo Jozo) USA Streptomycin Sulfate (Pfizer)... 

C2gH4jO 83-48-7) see Methandriol streptomycin hydrochloride (C2iH4 C1N70 2 7177-57-3) see Streptoniazid streptomycin sulfate... 

The cell-bound amylopullulanase was solubilized with detergent and lipase. It was then purified to homogeneity by treatment with streptomycin sulfate and ammonium sulfate, and by DEAE-Sephacel, octyl-Sepharose and puUulan-Sepharose column chromatography (12). The final enzyme solution was purified 3511-fold over the crude enzyme extract with an overall recovery of 42% and had a specific activity of 481 units/mg protein. The average molecular weight of the enzyme was 136,500 determined by gel filtration on Sephacryl S-200 and SDS-PAGE, and it had an isoelectric point at pH 5.9. It was rich in acidic and hydrophobic amino acids. The purified enzyme was quite thermostable in the absence of substrate even up to 90°C with essentially no loss of activity in 30 min. However, the enzyme lost about 40% of its original activity at 95 C tested for 30 min. The optimum tenq)erature for the action of the purified enzyme on pullulan was 90°C. However, the enzyme activity rapidly decreased on incubation at 95°C to only 38% of the maximal 30 min. The enzyme was stable at pH 3.0-5.0 and was optimally active at pH 5.5. It produced only maltotriose and no panose or isopanose from pullulan. 

Also refer to the streptomycin sulfate monograph in the Aminoglycosides. Parenteral section. 

Avoid concurrent or sequential use of other neurotoxic and/or nephrotoxic drugs with streptomycin sulfate, including neomycin, kanamycin, gentamicin, cephaloridine, paromomycin, viomycin, polymyxin B, colistin, tobramycin, and cyclosporine. 

Skin sensitivity Take care handling streptomycin for injection to avoid skin sensitivity reactions. As with all IM preparations, inject streptomycin sulfate injection well within the body of a relatively large muscle and take care to minimize the possibility of damage to peripheral nerves. 

Pharmacology Streptomycin sulfate is a bactericidal antibiotic that interferes with normal protein synthesis. 

For each test compound concentration, vehicle, negative or positive controls, make 8.25 mL of serum culture medium containing 70% rat serum, 30% sterile Tyrode s salt buffer with less than 1 mg/500 mL phenol red (free acid indicator) and 35 p,g/mL streptomycin sulfates. 

Aminoglycosides amikacin sulfate gentamicin sulfate netilmicin sulfate paromomycin sulfate streptomycin sulfate tobramycin sulfate... 

Oilier examples of this type of reaction are file conversion of the antibiotic streptomycin sulfate to its corresponding chloride hy means of anion exchange, the exchange of Na ions in milk for the K ion. and the conversion of NaCKdj to H CiOi by cation exchange The latter process is used extensively in the plaling industry to concentrate ICCrO, Iron rinse waters, with subsequent reuse of a toxic chemical ami reuse of ihe rinse water in what might be termed a closed system. 

Litchman and Upton [192] reported the determination of triethyla-mine in streptomycin sulfate and in methacycline hydrochloride to levels as low as 0.05%. A weighed sample was treated with 1M sodium hydroxide solution at 60°C for 1 hr. A headspace sample was manually withdrawn and analyzed on a polystyrene column at 160°C using a flame-ionization detector. The levels of triethylamine found ranged from 0.15% to 0.36% for streptomycin sulfate and from 0.06% to 0.13% for methacycline hydrochloride. Recoveries were better than 94%. The precision of the determination, based on five replicate weighings of sample, was 2% for streptomycin sulfate and 5% for methacycline hydrochloride. 

Kindig AC, Conquest LL, Taub FB. 1983. Differential sensitivity of new versus mature synthetic microcosms to streptomycin sulfate treatment. In Bishop WE, Cardwell RD, Heidolph BB, editors. Aquatic toxicology and hazard assessment sixth symposium. Volume ASTM STP 802. Philadelphia, (PA) American Society for Testing and Materials, p 192-203. 

Streptomycin Sulfate Streptomycin sulfate should be protected from moisture and is incompatible in the presence of acids and alkalis. Professionals who handle streptomycin should wear masks and rubber gloves, since streptomycin may cause severe dermatitis. 

Heparin and its salts are incompatible with many drugs including alteplase, amikacin sulfate, amiodarone hydrochloride, ampicillin sodium, aprotinin, benzylpenicillin potassium or sodium, cephalothin sodium, ciprofloxacin lactate, cytarabine, dacarbazine, daunorubicin hydrochloride, diazepam, dobutamine hydrochloride, doxorubicin hydrochloride, droperidol, erythromycin lactobionate, gentamicin sulfate, haloperidol lactate, hyaluronidase, hydrocortisone sodium succinate, kanamycin sulfate, methicillin sodium, netilmicin sulfate, some opioid analgesics, oxytetracycline hydrochloride, some phenothiazines, polymyxin B sulfate, streptomycin sulfate, tetracycline hydrochloride, tobramycin sulfate, vancomycin hydrochloride, vinblastine sulfate, cisatracurium besylate, labetalol hydrochloride, nicardipine hydrochloride, cefmetazole, sodium ions, and fat emulsion.110 112... 

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