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Doxorubicin hydrochloride

The chemotherapy of advanced Hodgkin s disease is one of the best examples of successful combination chemotherapy. Combination therapy with the MOPP regimen (mechlorethamine, Oncovin [vincristine sulfate], procarbazine, prednisone), alternating with ABVD (Adriamycin [doxorubicin hydrochloride], bleomycin, vinblastine, dacarbazine), has resulted in cure rates of 50 to 60%. [Pg.635]

Habib MJ, Asker AF. Photostabilization of doxorubicin hydrochloride with radioprotective and photoprotective agents potential mechanism for enhancing chemotherapy during radiotherapy. J Parenter Sci Technol 1989 43 259-261. [Pg.326]

Conversion of daunorobicin hydrochloride to 4 -epi-doxorubicin hydrochloride employing the trifluoroacetyl moiety for the 3 -amino group protection ... [Pg.1452]

H. G. Barth and A. Z. Conner, Determination of doxorubicin hydrochloride in pharmaceutical preparations using HPLC, J. Chromatogr., 131 375 (1977). [Pg.430]

Morphine Sulfate Morphine sulfate precipitates in alkaline media and drugs that are incompatible with it, including aminophylline, sodium salts of barbiturates, and phenytoin. Precipitate was found after 2 horns when morphine sulfate was formulated with acyclovir sodium.70 Incompatibilities also are reported with chlorpromazine hydrochloride injections containing chlorocresol. Admixture of morphine sulfate (1 mg/mL), doxorubicin in doxorubicin hydrochloride... [Pg.342]

Pethidine Hydrochloride Pethidine hydrochloride solutions are not compatible with barbiturates, aminophylline, morphine sulfate, sulfadiazine sodium, methicilline sodium, nitrofurantoin, phenytoin sodium, heparin sodium, sodium iodide, diethanolamine, sulfafurazol, acyclovir sodium, liposomal doxorubicin hydrochloride, frusemide, imipenem, and idarubicin. Visual incompatibilities are reported with mixtures of pethidine hydrochloride and cefoperazone sodium or mezlocillin sodium, nafcillin sodium and minocycline hydrochloride or tetracycline hydrochloride in 5% glucose injection.82 83... [Pg.344]

Heparin and its salts are incompatible with many drugs including alteplase, amikacin sulfate, amiodarone hydrochloride, ampicillin sodium, aprotinin, benzylpenicillin potassium or sodium, cephalothin sodium, ciprofloxacin lactate, cytarabine, dacarbazine, daunorubicin hydrochloride, diazepam, dobutamine hydrochloride, doxorubicin hydrochloride, droperidol, erythromycin lactobionate, gentamicin sulfate, haloperidol lactate, hyaluronidase, hydrocortisone sodium succinate, kanamycin sulfate, methicillin sodium, netilmicin sulfate, some opioid analgesics, oxytetracycline hydrochloride, some phenothiazines, polymyxin B sulfate, streptomycin sulfate, tetracycline hydrochloride, tobramycin sulfate, vancomycin hydrochloride, vinblastine sulfate, cisatracurium besylate, labetalol hydrochloride, nicardipine hydrochloride, cefmetazole, sodium ions, and fat emulsion.110 112... [Pg.349]

L.A. Trissel, et al., Compatibility of doxorubicin hydrochloride liposome injection with selected other drugs during simulated Y-site administration. Am. J. Health Sys. Pharmacol. 54 2708-2713, 1997. [Pg.365]

Milner LS, Wei SH, Houser MT (1991) Amelioration of glomerular injury in doxorubicin hydrochloride nephrosis by dimethylthiourea. J Lab Clin Med 118 427 134 Milner LS, Wei S, Kazakoff P et al. (1994) Synergistic effect of fish oil diet and dimethylurea in acute adriamycin nephrosis. AM J Med Sci 308 266-270 Mizuno S, Mizuno-Horikawa Y, Yue BF et al. (1999) Nephrotic mice (ICGN strain) A model of diffuse mesangial sclerosis in infantile nephrotic syndrome. Am J Nephrol 19 73-82... [Pg.132]

An antibiotic isolated from Streptomycespeucetius var. caesius. Doxorubicin Hydrochloride... [Pg.575]

Caution. Doxorubicin hydrochloride is irritant avoid contact with skin and mucous membranes. [Pg.575]

Infra-red Spectrum. Principal peaks at wavenumbers 1282, 990, 1010, 1587, 1612, 1204 (doxorubicin hydrochloride). [Pg.575]

Acetorphine Hydrochloride Medroxyprogesterone Acetate Niflumic Acid Aminocaproic Acid Doxorubicin Hydrochloride Diphenylpyraline Hydrochloride... [Pg.1090]

ADRIBLASTIN ADRIBLASTINE DOX HYDROCHLORIDE DOXORUBICIN DOXORUBICIN HYDROCHLORIDE O FI 106 n 6804... [Pg.753]

Asker AF, Habib MJ. Effect of glutathione on photolytic degradation of doxorubicin hydrochloride. J Parent Sci Tech 1988 42(5) 153-156. [Pg.40]

Drugs whose decomposition rates are influenced by the pH include doxorubicin hydrochloride (47), minoxidil (48), menadione sodium bisulfite (67), metronidazole (68), riboflavin (69), colchicine (70), tetracycline hydrochloride (71), phenobarbital (72), dacarbazine (73), furosemide (74), daunorubicin hydrochloride (75), and demeclo-cycline hydrochloride (76). Figures 3 to 6 illustrate how the pH of the solution can influence the degradation rate of some of the reported photolabile drugs. [Pg.351]

Ferdous and Asker (76) found that demeclocycline hydrochloride solution degraded more in clear than in amber glass vials when exposed to fluorescent radiation from cool white fluorescent tubes. Amber glass was also found to provide better protection for solutions of doxorubicin hydrochloride (47), minoxidil (48), and furosemide (74). Figures 15 and 16 illustrate the effect of type of glass on photodegradation of furosemide and democlocycline hydrochloride, respectively. [Pg.364]

Various UV absorbers have been used to protect photolabile solutions of drugs. p-Aminobenzoic acid absorbs UV radiation in the 360 to 313 nm UV region. Evidence of its photoprotective ability has been reported for solutions of colchicine (70), tetracycline hydrochloride (71), doxorubicin hydrochloride (77), and reserpine (106). [Pg.366]

Urocanic acid is considered one of the major absorbers of UV radiation in the epidermis with a at 278 nm at pH 7 (110) and therefore functions as a natural sunscreen (111). Habib and Asker (77) found that urocanic acid significantly enhanced the photostability of doxorubicin hydrochloride solutions. [Pg.366]

Uric acid in very low concentrations, very strongly absorbs UV radiation and for this reason, has been used to protect various FD C colors against fading when they will be probably exposed to direct sunlight (112). Uric acid has been found to enhance the photostability of solutions of colchicine (70) and FD C Blue No. 2 (82,113). Sodium urate, the neutral salt of uric acid, has a photoprotective effect on solutions of metronidazole (68), doxorubicin hydrochloride (77), and physostigmine sulfate (108). In addition to its photon-absorbing property, uric acid has been reported to also possess antioxidant quality (114). [Pg.366]

Sodium thiosulfate, however, is detrimental to the photostability of solutions of furosemide (74) and doxorubicin hydrochloride (77). [Pg.369]

In addition to dl-methionine, other amino acids also enhance the photostability of some drugs. Glycine was found to increase the photostability of doxorubicin hydrochloride (77) and furosemide (74). Dl-cysteine significantly increases the photostability of tetracycline hydrochloride (71). [Pg.369]

See other pages where Doxorubicin hydrochloride is mentioned: [Pg.1043]    [Pg.1043]    [Pg.1050]    [Pg.639]    [Pg.614]    [Pg.620]    [Pg.1050]    [Pg.380]    [Pg.36]    [Pg.1358]    [Pg.1083]    [Pg.1145]    [Pg.1662]    [Pg.349]    [Pg.367]    [Pg.369]    [Pg.103]    [Pg.521]    [Pg.523]   
See also in sourсe #XX -- [ Pg.69 ]



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