Vancomycin hydrochloride

Clinical Use. Vancomycin and teicoplanin as fomiulated dmgs are lyophilized powders to be reconstituted with sterile water for injection. Vancomycin hydrochloride [1404-93-9] is presented in vials of 500 mg that give 100—200 mL solution of pH 2.5—4.2. It is administered by slow (60 min) infusion at a dose of 500 mg every 6 h or 1 g every 12 h/d. The teicoplanin contains the five factors (87%) plus 13% of the pseudoaglycone T-A3-1. It is presented in vials containing 200 mg of lyophili ed power that after dissolution with 3 mL of solvent gives a solution at pH 7.5. The dose regimen is 200—800 mg/d by iv bolus adrninistration. 

Tarao K, Ikeda T, Hayashi K, Sakurai I A Successful use of vancomycin hydrochloride in the treatment of lactulose-resistant chronic hepatic encephalopathy. J Gastroenterol Hepatol 1989 4 284-286. 

Vancomycin hydrochloride 30 mg/kg per 24 hours IV in two equally divided doses not to exceed 2 g/24 hours unless serum concentrations are inappropriately low Pediatic dose 40 mg/kg 24 hours in two or three equally divided doses 4 IB Vancomycin therapy recommended only for patients unable to tolerate penicillin or ceftriaxone therapy... 

Vancomycin hydrochloride 30 mg/kg per 24 hours IV in two equally divided doses 6... 

VANCOMYCIN HYDROCHLORIDE STERILE USP 1GM VIAL 10 VIALS/PACKAGE 6505012478801 PG 61.03 ... 

Antibacterials ciprofloxacin hydrochloride co-trimoxazole (sulfamethoxazole/ trimethoprim) doxycycline hyclate mentronidazole vancomycin hydrochloride... 

Vancocin HC1 for oral solution contains vancomycin hydrochloride equivalent to 10 g (6.7 mmol) or 1 g (0.67 mmol) vancomycin. Calcium disodium edetate, equivalent... 

M. Mathew and V. DasGupta, Stability of vancomycin hydrochloride solutions at various pH values as determined by high-performance liquid chromatography, Drug Dev. Ind. Pharm., 27 100 (1994). 

Vancomycin Hydrochloride Solutions of vancomycin hydrochloride have an acid pH and incompatibility may reasonably be expected with alkaline preparations or drugs unstable at low pH. Vancomycin interacts with aminoglycosides, loop diuretics, general anesthetics, and neuromuscular blockers. 

Heparin and its salts are incompatible with many drugs including alteplase, amikacin sulfate, amiodarone hydrochloride, ampicillin sodium, aprotinin, benzylpenicillin potassium or sodium, cephalothin sodium, ciprofloxacin lactate, cytarabine, dacarbazine, daunorubicin hydrochloride, diazepam, dobutamine hydrochloride, doxorubicin hydrochloride, droperidol, erythromycin lactobionate, gentamicin sulfate, haloperidol lactate, hyaluronidase, hydrocortisone sodium succinate, kanamycin sulfate, methicillin sodium, netilmicin sulfate, some opioid analgesics, oxytetracycline hydrochloride, some phenothiazines, polymyxin B sulfate, streptomycin sulfate, tetracycline hydrochloride, tobramycin sulfate, vancomycin hydrochloride, vinblastine sulfate, cisatracurium besylate, labetalol hydrochloride, nicardipine hydrochloride, cefmetazole, sodium ions, and fat emulsion.110 112... 

Warfarin sodium may be adsorbed to PVC and intravenous infusion sets but may be minimized with glass containers or polyethylene-lined containers. Warfarin sodium is incompatible with solutions of adrenaline hydrochloride, amikacin sulfate, metaraminol tartrate, oxytocin, promazine hydrochloride, tetracycline hydrochloride, aminophylline, bretylium tosylate, ceftazidime, cimetidine hydrochloride, ciprofloxacin lactate, dobutamine hydrochloride, esmolol hydrochloride, gentamicin sulfate, labetalol hydrochloride, metronidazole hydrochloride, and vancomycin hydrochloride.130131... 

Tripotassium dicitrato bismuthate Triptorelin injection Tromantadine hydrochloride Vancomycin hydrochloride injection... 

Ultraviolet Spectrum. Vancomycin hydrochloride aqueous acid—281 nm (A = 34 b). 

Valrelease, 526 Vamidothion, 85 Van Deemter plots, 191 Van Urk reagent, 1171 Vancenase, 374 Vanceril, 374 Vancocin, 1060 Vancomycin, 1060 Vancomycin hydrochloride, 1060 Vandid, 593... 

Vancomycin hydrochloride is always administered intravenously (never intramuscularly), either by slow injection or hy continuous infusion, for the treatment of systemic infections. In shott-term therapy, the toxic side reactions arc usually slight, hut continued u.sc may lead to impaired auditory acuity, renal damage, phlebitis, and rashes. Bccau.se it is nut assorted or signilicantly degraded in the gastrointc.stinal tract, vancomycin may he administered orally fur the treatment of staphylococcal enterocolitis and for pseudomembranous colitis associated with clindamycin therapy. Some conversion to aglucovancomycin likely (Kcurs in the low pH of the stomach. The latter retains about three-fourths of the activity of vancomycin. 

Vancomycin hydrochloride.. 5.. . 56 Van dcr Waals loax-s.. 1.. It Van dcr Waats surface, in luoicLitlai miHlcliiig. 922. 922f... 

Vancomycin hydrochloride 30 mg/kg per 24 h IV in two equally divided doses, not to exceed 2 g/24 h unless serum levels are monitored 4 Vancomycin therapy is recommended for patients allergic to yfi-lactams (see text regarding drug levels) according to the guidelines, serum concentrations of vancomycin should be obtained 1 h after completion of the infusion and should be in the range of 30-45 mcg/mL for twice-daily dosing... 

Vancomycin hydrochloride -Methicillin-Resistant Staphylococci 30 mg/kg per 24 h IV in two equally divided doses, not to exceed 2g/24 h unless serum levels are monitored 4-6... 

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