Ciprofloxacin hydrochloride ophthalmic

The ciprofloxacin hydrochloride ophthalmic ointment consists of synthetic, sterile, multiple-dose, antimicrobials for topical ophthalmic use. Ciprofloxacin is a fluoroquinolone antibacterial that is active against a broad spectrum of gram-positive and gram-negative ocular pathogens. It is available as the monohydrochloride monohydrate salt of 1-cyclopropyl-6-fluoro-l,4-dihydro-4-oxo-7-(l-piperazinyl)-3-quinoline-carboxylic acid. It is a faint to light-yellow... 

Charoo, N. A., Kohli, K., Ali, A., and Anwer, A. (2003), Ophthalmic delivery of ciprofloxacin hydrochloride from different polymer formulations In vitro and in vivo studies, Drug Dev. Ind. Pharm., 29(2), 215-221. 

Balasubramaniam J, Pandit JK. Ion-activated in situ gelling systems for sustained release ophthalmic delivery of ciprofloxacin hydrochloride. Drug Delivery 2003 10(3) 185-191. 

Ciprofloxacin is commercially available as the monohydrate phase of its hydrochloride salt, and has been formulated for oral and ophthalmic administration. The compound has also been developed as the lactate salt for use in intravenous administration [3]. 

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