Bretylium tosylate

Quaternization of o-bromo-iv,iv-dimethyIbenzylamine with the p-toluene-sulfonate of ethanol affords bretylium tosylate (78), an antihypertensive agent acting by peripheral sympathetic blockade. [Pg.55]

Brompheniramine maleate N-o-Bromobenzyl-(M,N -dimethylamine Bretylium tosylate... [Pg.1618]

Ethyl p-toluenesulfonate Bretylium tosylate N-ethyl o-toluidine Crotamiton Ethyl undecylenate lophendylate Ethyl urethane Mebuta mate 170 -Ethynyl estradiol Quinestrol... [Pg.1634]

Bretylate, molecular formula and structure, 5 96t Bretylium, molecular formula and structure, 5 96t Bretylium tosylate, 4 359t 5 103 Bretylol, molecular formula and structure, 5 96t... [Pg.117]

Pharmacology Bretylium tosylate inhibits norepinephrine release by depressing adrenergic nerve terminal excitability, inducing a chemical sympathectomy-like state. Bretylium blocks the release of norepinephrine in response to neuron stimulation. Peripheral adrenergic blockade causes orthostatic hypotension but has less effect on supine blood pressure. It has a positive inotropic effect on the myocardium. Pharmacokinetics Peak plasma concentration and peak hypotensive effects are seen within 1 hour of IM administration. However, suppression of premature ventricular beats is not maximal until 6 to 9 hours after dosing, when mean plasma concentration declines to less than 50% of peak level. Antifibrillatory effects occur within minutes of an IV injection. Suppression of ventricular tachycardia and other ventricular arrhythmias develops more slowly, usually 20 minutes to 2 hours after parenteral administration. [Pg.463]

Premix Solutions-. 500 mg/250 ml, 1000 mg/250 ml (Bretylium Tosylate-Dextrose). Indications and Dosages ... [Pg.151]

Antiadrenergic and cardiac depressant bretylium tosylate [61-75-6] CnH17BrN -xC7H703S... [Pg.299]

Bretylium is available only for intravenous use in the USA. In adults, an intravenous bolus of bretylium tosylate, 5 mg/kg, is administered over a 10-minute period. This dosage may be repeated after 30 minutes. Maintenance therapy is achieved by a similar bolus every 4-6 hours or by a constant infusion of 0.5-2 mg/min. [Pg.337]

Warfarin sodium may be adsorbed to PVC and intravenous infusion sets but may be minimized with glass containers or polyethylene-lined containers. Warfarin sodium is incompatible with solutions of adrenaline hydrochloride, amikacin sulfate, metaraminol tartrate, oxytocin, promazine hydrochloride, tetracycline hydrochloride, aminophylline, bretylium tosylate, ceftazidime, cimetidine hydrochloride, ciprofloxacin lactate, dobutamine hydrochloride, esmolol hydrochloride, gentamicin sulfate, labetalol hydrochloride, metronidazole hydrochloride, and vancomycin hydrochloride.130131... [Pg.350]

Note. For further information on bretylium tosylate see E. R. Garrett era/., Biopharm. Drug Disp., 1982, 5,129-164. [Pg.400]

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