Tetracycline hydrochloride

See section on treatment of bacterial pneumonia. Macrolide/azalide erythromycin, clarithromycin, azithromycin. cTetracydine tetracycline hydrochloride, doxycydine. Cephalosporin cefuroxime, ceftriaxone, cefotaxime. eCarbapenem imipenem-cilastatin, meropenem. Fluoroquinolone ciprofloxacin, gatifloxacin, or levofloxacin. 

On this basis the drug tetracycline hydrochloride has been identified. Its percentage in a tablet has also been established. 

Vander Heyden, Y., Luypaert, K., Hartmann, C., Massart, D. L., Hoogmartens, J., and De Beer, J. (1995). Ruggedness tests on the high-performance liquid chromatography assay of the United States Pharmacopeia XXII for tetracycline hydrochloride. A comparison of experimental designs and statistical interpretations. Anal. Chim. Acta 312, 245-262. 

Tetracycline hydrochloride Achromycin, Panamycin, Hydrochloride Oral, IV 8 25-60... 

Antibiotics erythromycin erythromycin estolate minocycline hydrochloride tetracycline hydrochloride... 

Tetracycline hydrochloride and minocycline sulfosalicylate are used in the treatment of acne vulgaris. 

The oral dosage for rapidly excreted tetracyclines, equivalent to tetracycline hydrochloride, is 0.25-0.5 g four times daily for adults and 20-40 mg/kg/d for children (8 years of age and older). For severe systemic infections, the higher dosage is indicated, at least for the first few days. The daily dose is 600 mg for demeclocycline or methacycline, 100 mg once or twice daily for doxycycline, and 100 mg twice daily for minocycline. Doxycycline is the oral tetracycline of choice because it can be given as a once-daily dose and its absorption is not significantly affected by food. All tetracyclines chelate with metals, and none should be orally administered with milk, antacids, or ferrous sulfate. To avoid deposition in growing bones or teeth, tetracyclines should be avoided in pregnant women and children less than 8 years of age. 

Burger, A. and Ratz, A.W. (1990). Physical and chemical stability of amorphous and crystalline tetracycline hydrochloride,Sci. Pharm., 58 69-75. 

Asker AF, Habib MJ. Effect of certain additives on photodegradation of tetracycline hydrochloride solutions. J Parenter Sci Technol 1991 45 113-115. 

Tetracycline and tetracycline hydrochloride have been mostly used synonymously in this monography. Literature cites quite often tetracycline but it is presumed to be valid also for tetracycline hydrochloride. Generally solutions of tetracycline are made in dilute acids. Physical properties, spectra etc are given for tetracycline hydrochloride. 

---