Cimetidine hydrochloride

Figure 1 is the infrared spectrum of cimetidine free base. Figure 2 is the infrared spectrum of cimetidine hydrochloride. The spectra were obtained as mineral oil dispersions from 400-625 cm-1 on a Perkin-Elmer Model 457A infrared spectrometer. The significant absorption bands in the spectra are ... 

The proton magnetic resonance spectrum of cimetidine hydrochloride was obtained by preparing a solution of approximately 100 mg/ml of the chanical in deuterated dimethyl sulfoxide containing tetramethylsilane as the internal standard. The chanical shift values of the hydrochloride salt differ from those of the free base and are ... 

The broad band decoupled carbon-13 NMR spectrum of cimetidine hydrochloride (Figure 3) was obtained by using a solution of approximately 100 mg/ml in deuterated dimethylsulf oxide. The deuterium signal of dimethylsulfoxide was used as the internal reference and the spectrum was obtained on a Varian Associates Model FT-80 fourier transform NMR spectrometer. The chemical shift assignments are ... 

This test may be used with the chemical, tablet, or liquid dosage form containing cimetidine or cimetidine hydrochloride. 

Fig. 12. Differential scanning calorimetric thermogram of cimetidine hydrochloride. 

The thermogravimetric curves for cimetidine and cimetidine hydrochloride are shown in Figure 13 and 14, respectively. The curves show that the compounds are stable up to a temperature of approximately 175-185°C and then decompose. The thermograms were obtained at a heating rate of 10°C/minute. 

Aqueous solutions of cimetidine and cimetidine hydrochloride are usually colorless to a very pale straw color. A saturated solution of the free base has a pH of approximately 9.0 and a 15% solution of the hydrochloride salt, a pH of approximately 3.7. 

A. Cimetidine and cimetidine hydrochloride have characteristic spectra (Figures 1 and 2). 

B. The ultraviolet absorption spectrum of a solution of cimetidine or cimetidine hydrochloride in 0.1N H2SO1, exhibits a maximum between 217 and 219 nm and a minimum at 210-212 nm (Figure 3). 

Warfarin sodium may be adsorbed to PVC and intravenous infusion sets but may be minimized with glass containers or polyethylene-lined containers. Warfarin sodium is incompatible with solutions of adrenaline hydrochloride, amikacin sulfate, metaraminol tartrate, oxytocin, promazine hydrochloride, tetracycline hydrochloride, aminophylline, bretylium tosylate, ceftazidime, cimetidine hydrochloride, ciprofloxacin lactate, dobutamine hydrochloride, esmolol hydrochloride, gentamicin sulfate, labetalol hydrochloride, metronidazole hydrochloride, and vancomycin hydrochloride.130131... 

Amsacrine Amsacrine is incompatible with sodium chloride mixtures and glucose-containing injections with acyclovir sodium, ganciclovir sodium, aztreonam, amphotericin, cimetidine hydrochloride, ceftazidime, frusemide, ceftriaxone sodium, heparin sodium, methylprednisolone sodium succinate, metoclopramide hydrochloride, and some antineoplastics.204 Asparaginase is incompatible with many drugs and rubber, and should be stored at 2° to 8 °C for stability. 

Ku, Y.-M. Min, D.I. Kumar, V. Noormohamed, S.E. Compatibility of tacrolimus injection with cimetidine hydrochloride injection in 0.9% sodium chloride injection. Am.J.Health-Syst.Pharm., 1995, 52, 2024-2025... 

Mahata, M.C. Morosco, R.S. Hippie, T.F. Stability of cimetidine hydrochloride and of clindamycin phosphate in water for injection stored in glass visds at two temperatures. Am.J.Hosp.Pfuxrm., 1993,50, 2559-2561... 

Elliott, G.T. McKenzie, M.W. Curry, S.H. Pieper, J.A. Quinn, S.L. Stability of cimetidine hydrochloride in admixtures after microwave thawing. Am.J.Hosp.Pharm., 1983, 40, 1002—1006 [stabilily-indicat-ing 5% dextrose saline]... 

Nahata, M.C. Morosco, R.S. Sabados, B.K. Weber, T.R. Stability and compatibility of anakinra with intravenous cimetidine hydrochloride or famotidine in 0.9% sodium chloride injection, J.Clin.Pharm. Ther., 1995,20, 97-99. 

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