Chondroitin

Metabolic Functions. Manganese is essential for normal body stmcture, reproduction, normal functioning of the central nervous system, and activation of numerous enzymes (126). Synthesis of the mucopolysaccharide chondroitin sulfate involves a series of reactions where manganese is required in at least five steps (127). These reactions are responsible for formation of polysaccharides and linkage between the polysaccharide and proteins that form... [Pg.386]

CS, chondroitin sulfate DS, dermatan sulfate HS, heparan sulfate (an analog of heparin) ... [Pg.291]

Danaparoid (Orgaran mean MW, 6,000 Da) is a mixture of nonheparin glycosaminoglycans derived from pig gut (dermatan sulfate, heparan sulfate, chondroitin sulfate). Die anti-Xa/anti-IIa ratio (22 1) is even greater than seen with LMWH. Die anti-IIa effect may be mediated in part by dermatan sulfate, which catalyzes thrombin inhibition by heparin cofactor II. [Pg.110]

Chondroitin Chondroitin sulfate, chondroitin sulfuric acid, chonsurid Arthritis None significant if used as directed Because chondroitin is concentrated in cartilage, theoretically it produces no toxic or teratogenic effects. [Pg.659]

FlC. 32.—Antiparallel packing arrangement of the 2-fold helices of calcium chondroitin 4-sulfate (35). (a) Stereo view of two unit cells approximately normal to the he-plane. The two comer chains, drawn in filled bonds are hydrogen bonded to the antiparallel center chain (open bonds). Calcium ions (crossed circles), associating with sulfate and carboxylate groups and water molecules link adjacent antiparallel chains, which ate also directly hydrogen bonded. [Pg.381]

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