Chondroitin structure

This substance is widely distributed in animal tissues. Its structure is similar to that of chondroitin sulfate, ex-... 

Chondroitin sulfates are located at sites of calcification in endochondral bone and are also found in cartilage. They are also located inside certain neurons and may provide an endoskeletal structure, helping to maintain their shape. 

Richy F, Bruyere O, Ethgen O, et al. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis A comprehensive meta-analysis. Arch Intern Med 2003 163 1514-1522. 

Fig. 19 Structures of glycosaminoglycans (A) chondroitin-4-sulfate (B) heparin sulfate (C) dermatin sulfate (D) hyaluronic acid (E) chondroitin-6-sulfate (F) keratin sulfate. 

Structural Studies on Chondroitin Sulfuric Acid. I. The Nature of... 

The first constitutional studies were made by Schmiedeberg97 who gave a general idea of the type of structure in chondroitin. Levene considered that the molecule was a tetrasaccharide composed of two glucuronic acid residues conjugated with two units of chondrosamine, esterified with sulfuric acid. On hydrolysis with hydrochloric acid the... 

The methylated derivatives served as the basis of elegant studies in which Jeanloz and his colleagues unequivocally established the structure of hyaluronan, dermatan sulfate, and the chondroitin sulfates. They also clarified many confusing issues, including the position of the sulfate groups in these polymers. In the course of this work, they proved that dermatan sulfate contained L-iduronic acid, a sugar not known before to occur in nature. 

Due to its similar structure to chondroitin sulfate and its ability to absorb 200-300 times its weight in water, many investigators have hypothesized that this brown... 

This compound was designed as potential inhibitor of chondroitin AC lyase from Flavobacterium heparinum, useful for the structural analysis of the enzyme active site. 

Zamfir A, Seidler DC, Kresse H, Peter-Katalinic J. 2002. Structural characterization of chondroitin/dermatin sulfate oligosaccharides from bovine aorta by capillary electrophoresis and electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Rapid Commun Mass Spectrom 16 2015. 

The primary structure of chondroitin 4-sulfate is the repeated disaccharide... 

Figure 3. Conformation of the K chondroitin 4-sulfate structure viewed normal to and along the helix axis. The 03 05 hydrogen bonds are shown by broken lines. (Reproduced with permission from ref. 18. Copyright 1983 Academic Press Inc.)...

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