Chondroitin sulfate, matrix systems

Chondroitin sulfate was identified in embryonic basement membrane on the basis of studies showing the susceptibility of sulfate-labeled material to chondroitinase and a reaction with monoclonal antibodies (Couchman et al., 1984 Paulsson et al., 1985b). Similarly, Reichert s membrane, endothelial L2, PYS cells, EHS tumor cells, and isolated glomeruli produce variable amounts of these proteoglycan (Oohira et al., 1983 Stow et al., 1983 Oldberg et al., 1981 Tyree et al., 1984 Hassell et al., 1980). The molecule produced by L2 cells (Mr 40K) contains a small protein core with a unique amino acid sequence (Bourdon et al., 1985). It appears that in such systems, little of the chondroitin sulfate proteoglycan is deposited in the matrix. 

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