Chondroitin sulfate-proteoglycan

CS-PG, chondroitin sulfate-proteoglycan these are similar to the dermatan sulfate PGs (DS-PGs) of cartilage ffable 48-11). SPARC, secreted protein acidic and rich in cysteine. 

CSPG chondroitin sulfate proteoglycans GAP GTPase-activating protein... 

Laabs, T., Carulli, D., Geller, H. M., and Fawcett, J. W. (2005). Chondroitin sulfate proteoglycans in neural development and regeneration. Curr. Opin. Neurobiol. 15,116-120. 

Moyano, J. V., Carnemolla, B., Albar, J. P., Leprini, A., Gaggerol, B., Zardi, L., and Garcia-Pardo, A. (1999). Cooperative role for activated a4pl integrin and chondroitin sulfate proteoglycans in cell adhesion to the heparin III domain of fibronectin. ]. Biol. Chem. 274, 135-142. 

Proteoglycans bind to a variety of different proteins and polysaccharides. For example, the large extracellular matrix protein tenascin, which is important to adhesion, cell migration, and proliferation, binds to chondroitin sulfate proteoglycans such as neurocan.225 Syndecan, a transmembrane proteoglycan, carries both chondroitin and heparan sulfate chains, enabling it to interact with a variety of proteins that mediate cell-matrix adhesion.185... 

Nader HB. Characterization of heparan sulfate and a particular chondroitin 4-sulfate proteoglycan from platelets. Inhibition of the aggregation process by platelet chondroitin sulfate proteoglycan. J Biol Chem 1991 266( 16) 10518-10523. 

Oligosaccharide Fragments Isolated from the Carbohydrate-Protein Linkage-Region of Chondroitin Sulfate Proteoglycans... 

Chondroitin sulfate was identified in embryonic basement membrane on the basis of studies showing the susceptibility of sulfate-labeled material to chondroitinase and a reaction with monoclonal antibodies (Couchman et al., 1984 Paulsson et al., 1985b). Similarly, Reichert s membrane, endothelial L2, PYS cells, EHS tumor cells, and isolated glomeruli produce variable amounts of these proteoglycan (Oohira et al., 1983 Stow et al., 1983 Oldberg et al., 1981 Tyree et al., 1984 Hassell et al., 1980). The molecule produced by L2 cells (Mr 40K) contains a small protein core with a unique amino acid sequence (Bourdon et al., 1985). It appears that in such systems, little of the chondroitin sulfate proteoglycan is deposited in the matrix. 

Kmsius T, Finne J, Margohs RK, Margohs RU. Identification of an 0-glycosidic mannose-linked sialylated tetrasaccharide and keratan sulfate oligosaccharides in the chondroitin sulfate proteoglycan of brain. J. Biol. Chem. 1986 261(18) 8237-8242. 

Koprivica V, et al. EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans. 

Zuo J, Neubauer D, Dyess K, Ferguson TA, Muir D (1998) Degradation of chondroitin sulfate proteoglycan enhances die neurite-promoting potential of spinal cord tissue. Exp Neurol 154 654-662. 

Jones LL, Yamaguchi Y, Stallcup WB, Tuszynski MH (2002) NG2 is a major chondroitin sulfate proteoglycan produced after spinal cord injury and is expressed by macrophages and oligodendrocyte progenitors. J Neurosci 22 2792-2803. 

Jones LL, Margolis RU, Tuszynski MH (2003) The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury. Exp Neurol 182 399 11. 

Razin, E., Stevens, R.L., Akiyama, F., Schmid, K. and Austen, K.F. (1982). Culture from mouse bone marrow of a subclass of mast cells possessing a distinct chondroitin sulfate proteoglycan with glycosaminoglycans rich in N-acetylgalactosamine-4,6-disulphate. J. Biol. Chem. 257, 7229-7236. 

Iwata, M., Carlson, S. S. (1993). A large chondroitin sulfate proteoglycan has the characteristics of a general extracellular matrix component of adult brain. J. Neurosci. 13,195-207. 

Chondroitin, dermatan and their sulfates. Chondroitin sulfate proteoglycans have been localized to cartilage, bone, cornea and intervertebral disc, whereas dermatan sulfate is found in skin and aorta. In addition to its mechanical role, appears to have a host of regulatory functions. 

XV [al(XV)]3 Core protein of chondroitin sulfate proteoglycan Widespread near basal lamina in muscle... 

---