Chondroitin sulfate-protein complex, biosynthesis

Early studies of the turnover of the chondroitin sulfate protein complex of rat costal cartilage (Gross ei al., I960) show-ed that the carbohydrate and protein moieties were metabolized at the same rate. Similarly, Campo and Dziewiatkowski (1962) found that the formation of both moieties proceeded in a roughly parallel fashion in cartilage preparations incubated in vitro. However, these experiments did not permit any conclusions as to the order in which the tw O components were synthesized. The investigations of the eell-frcc biosynthesis of the protein polysaccharide, reviewed above, have indicated that the synthesis of the protein core, or at least part of it, precedes the formation of the chondroitin sulfate chains and... 

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