Syrian hamster cells transformation

Kaul, K.L. Novak, R.F. (1987) Inhibition and induction of rabbit liver microsomal cytochrome P-450 by pyridine. J. Pharmacol, exp. Ther., 243, 384-390 Kerckaert, G.A., Brauninger, R., LeBoeuf, R.A. Isfort, R.J. (1996) Use of the Syrian hamster cell transformation assay for carcinogenicity prediction of chemicals currently being tested by the National Toxicology Program in rodent bioassays. Environ. Health Perspect, 104 (Suppl. 5), 1075-1084... 

Hesterberg TW, Butterick CJ, Oshimura M, et al. 1986. Role of phagocytosis in Syrian hamster cell transformation and cytogenetic effects induced by asbestos and short and long glass fibers. Cancer Res 46 5795-5802. 

DiPaolo JA, Casto BC. 1979. Quantitative studies of in vitro morphological transformation of Syrian hamster cells by inorganic metal salts. Cancer Res 39 3008-1013. 

Cell transformation, SA7/Syrian hamster cells ND + Hatch et al. (1982)... 

Xylene of unspecified grade did not induce morphological transformation in cultured Syrian hamster cells. 

There are also data that indicate that aluminum does not directly interact with DNA in mutagenicity tests. These data come from negative transformation assays in Syrian hamster cells (DiPaolo and Casto 1979), negative rec (recombination repair) assays in Bacillus subtilis (Kanematsu et al. 1980), and negative Ames assays in Salmonella typhimurium (Marzin and Phi 1985). These data are summarized in Table 2-4. 

J.A. DiPaolo et al., Nitration of carcinogenic and noncarcinogenic polycyclic aromatic hydrocarbons results in products able to induce transformation of Syrian hamster cells. Carcinogenesis 4, 357-359 (1983)... 

Oshimura M, Hesterberg TW, Barrett JC. 1986. An early, nonrandom karyotypic change in immortal Syrian hamster cell lines transformed by asbestos Trisomy of chromosome 11. Cancer Genet Cytogenet 22 225-237. 

Transformation of Syrian Hamster Cells by Metals. When cultures of cells were exposed to two nickel compounds with different carcinogenic potencies, there were differences in the incidence of transformed colonies that formed (Table II). Treatment with amorphous NiS resulted in a low incidence of transformation while treatment with crystalline NiaS2 induced the appearance of numerous transformed colonies (Table II). In this series of experiments, control cultures had no transformed colonies however, in some experiments there was an occasional incidence of spontaneous transformation. The induction of transformation by... 

Carcinogenic metal compoimds such as crystalline Ni3S2 induced a dose-dependent statistically significant incidence of transformation in secondary cultures of Syrian hamster cells. A chemically related compound, amorphous NiS, which is not carcinogenic, resulted in no statistically significant incidences of transformed colonies. Untreated control cultures also had no statistically significant incidence of transformation. We have... 

In this chapter, emphasis will be placed on the use of early passage Syrian hamster cells for identifying carcinogens. Results from this cell transformation system will be correlated with reported results from the bacterial mutagenesis system and chronic carcinogenicity tests in animals. 

Y. Ishii, J. A. Elliott, N. K. Mishra, and M. W. Lieberman, Quantitative studies of transformation by chemical carcinogens and ultraviolet radiation using a subclone of BHK21 Clone 13 Syrian hamster cells. Cancer Res. 37, 2023-2029 (1977). 

Syrian hamster embryo cells (clonal assay) Cell transformation No data — Amacher and Zelljadt 1983... 

Amacher DE, Zelljadt I. 1983. The morphological transformation of Syrian hamster embryo cells by chemicals reportedly nonmutagenic to Salmonella typhimurium. Carcinogenesis 4 291-295. 

Hayashi, N. Hasegawa, K. Barrett, J. C. Tsutsui, T. Estrogen-induced cell transformation and DNA adduct formation in cultured Syrian hamster embryo cells. Mol. Carcinog. 1996, 16, 149-156. 

Dunkel VC, Pienta RJ, Sivak A, et al. 1981. Comparative neoplastic transformation responses of Balb/3T-3 cells, Syrian hamster embryo cells, and Rauscher murine leukemia virus-infected Fischer 344 rat embryo cells to chemical carcinogens. J Nat Cancer Inst 67 1303-1315. 

Pienta RJ, Poiley JA, Lebherz WB III. 1977. Morphological transformation of early-passage golden Syrian hamster embryo cells derived from cryopreserved primary cultures as a reliable in vitro bioassay for identifying diverse carcinogens. Int J Cancer 19 642-655. 

Hepatocyte primary cultures Hepatocyte primary cultures Cell transformation Syrian hamster embryo cells... 

Sanner T, Rivedal E. 1985. Tests with the Syrian hamster embryo (SHE) cell transformation assay. In Ashby J, de Serres FJ, et al., eds. Progress in mutation research. Vol. 5. Evaluation of short-term tests for carcinogens. Amsterdam, The Netherlands Elsevier Science Publishers, 665-671. Sato M, Ishizu S, Momotuni H. 1975. [Determination of acrylonitrile, cyanide and thiocyanate in blood and urine.] Jap J Ind Health 17 99-105. (Japanese). 

Aniline transformed the Balb/3T3 mouse cell line at doses of 0.8 to 100 /dose-response effect), but not the Syrian hamster embryo cells (Dunkel et al. 1981). Results were negative in DNA damage assays in Escherichia coli (Mamber et al. 1983) and Bacillus subtilis (McCarroll et al. 1981). 

Lee, T.C., M. Oshimura, and J.C. Barrett. 1985. Comparison of arsenic-induced cell transformation, cytotoxicity, mutation and cytogenetic effects in Syrian hamster embryo cells in culture. Carcinogenesis 6 1421-1426. 

On the other hand, mercuric chloride, at a concentration of 50 /iM, also has been shown to enhance viral transformation of Syrian hamster embryo cells [252],... 

Tsutsui T, Hayashi N, Maizumi H, et al. 1997. Benzene-, catechol-, hydroquinone- and phenol-induced cell transformation, gene mutations, chromosome aberrations, aneuploidy, sister chromatid exchanges and unscheduled DNA synthesis in Syrian hamster embryo cells. Mutat Res 373 113-123. 

In Vitro Syrian Hamster Embryo Cell Transformation Test. 308... 

Isfort, R.J., Cody, D.B., Doerson, C., Kerckaert, G.A., and LeBoeuf, R.A., Alterations in cellular differentiation, mitogenesis, cytoskeleton and growth characteristics during Syrian hamster embryo cell multistep in vitro transformation, Int. J. Cancer, 59, 114, 1994. 

Engelhardt, G., Schwind, K.-R., and Mulller, B., The testing of chemicals in the Syrian hamster embryo (SHE) cell transformation assay for assessment of carcinogenic potential, Toxicology In Vitro, 8, 213, 2004. 

LeBoeuf, R.A., and Kerckaert, G., Enhanced morphological transformation of early passage Syrian hamster embryo cells cultured in medium with a reduced bicarbonate concentration and pH, Carcinogenesis, 8, 680, 1987. 

Syrian hamster embryo cells Enhanced transformation by SA7 adenovi res No data - Hatch et al. 1983... 

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