Predictions carcinogenicity

Kerckaert, GA., Brauninger, R., LeBoeuf, R.A. Isfort, R.J. (1996) Use of the Syrian hamster embryo cell transformation for carcinogenicity prediction of chemicals currently being tested by the National Toxicology Program in rodent bioassays. Environ. Health Perspect., 104 (Suppl. 5), 1075-1084... 

Mid 1990s The National Toxicology Program s carcinogenicity prediction challenge highlights the difficulty of estimating this endpoint... 

Table 8.3 First NTP Comparative Exercise on the Prediction of Rodent Carcinogenicity Prediction Systems...

Lagunin AA, Dearden JC, Filimonov DA, Poroikov VV. Computer-aided rodent carcinogenicity prediction. Mutat Res 2005 586 138-46. 

Lee Y, Buchanan BG, Rosenkranz HS. Carcinogenicity predictions for a group of 30 chemicals undergoing rodent cancer bioassays based on rules derived from subchronic organ toxicities. Environ Health Perspect 1996 104S(5) 1059—1063. 

A useful resource related to carcinogenicity, includes a wide array of publications from the Carcinogenic Potency Project. The references include papers on methodological analysis of the relevance of carcinogenicity prediction from bioassays, species comparisons, target organs, mechanism of carcinogenesis, risk assessment techniques, possible cancer hazards of natural and synthetic chemicals, and causes and prevention of cancer. 

Table 9.5. Results of carcinogenicity prediction (from Hileman 1993, copyright (1993) American Chemical Society)...

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