Chemicals carcinogenicity

In additional EPA studies, subchronic inhalation was evaluated ia the rat for 4 and 13 weeks, respectively, and no adverse effects other than nasal irritation were noted. In the above-mentioned NTP chronic toxicity study ia mice, no chronic toxic effects other than those resulting from bronchial irritation were noted. There was no treatment-related increase ia tumors ia male mice, but female mice had a slight increase in bronchial tumors. Neither species had an increase in cancer. Naphthalene showed no biological activity in other chemical carcinogen tests, indicating Htde cancer risk (44). No incidents of chronic effects have been reported as a result of industrial exposure to naphthalene (28,41). 

Some occupational hygiene aspects of man-made mineral fibres and new technology fibres Safe handling requirements dunng explosive, propellant and pyrotechnic manufacture Simplified calculations of blast induced injuries and damage Laboratory work with chemical carcinogens and oncogenes Rosin (colophony) a review... 

CCRIS - Chemical Carcinogenicity Research Information System... 

Cancer is a disorder of the body s control of the growth of cells. For a list of examples of human chemical carcinogens, and the relevant target organs, refer to Table 4.10. 

Richard AM, Benigni R. AI and SAR approaches for predicting chemical carcinogenicity survey and status report. SAR QSAR Environ Res 2002 13 1-19. 

Third, reactions of activated species of chemical carcinogens with DNA are thought to be of great importance in chemical carcinogenesis. Some chemicals (eg, benzojajpyrene) require activation by monooxygenases... 

The involvement of tobacco smoke carcinogens in the aetiology of lung cancer is conclusively established, but the role of specific chemical carcinogens as inducers of colorectal cancer is much less clear. Mutagenic pyrolysis products derived from cooked food have come under suspicion as possible... 

FAHEY J w, ZHANG Y and TALALAY P (1997) Btoccoli sprouts an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens , Proc Natl AcadSci USA, 94 10367-72. 

Magee, P.N. Montesano, R. Preussmann, R. "Chemical Carcinogens American Chemical Society Monograph 173 Washington, DC, 1976, pp. 491-625. 

Magee, P N Montesano, R Preussmann, R IN Searle, Charles E, Ed "Chemical Carcinogens" American Chemical Society Washington, DC, 1976 pp 491-625 ... 

Mahaffey WR, DT Gibson, CE Cerniglia (1988) Bacterial oxidation of chemical carcinogens formation of polycyclic aromatic acids from benz[a]anthracene. Appl Environ Microbiol 54 2415-2423. 

Roman-Franco, A.A. (1982). Non-enzymic extramicrosomal activation of chemical carcinogens by phagocytes a proposed new pathway. J. Theor. Biol. 97, 543-555. 

Other factors associated with the risk of NMSC include exposure to ionizing radiation and arsenic, which is connected with BCC. Chemical carcinogens that give rise to NMSC include industrial hydrocarbons that are found in coal tars, soot, asphalt, paraffin waxes, and tobacco.21 Exposure to the human papilloma virus (HPV-6, -11, -16, and -18) has been linked to SCC.31 Lastly, a personal history of previous melanoma is a risk factor for developing another primary melanoma. 

Dunkel VC, Pienta RJ, Sivak A, et al. 1981. Comparative neoplastic transformation responses of Balb/3T-3 cells, Syrian hamster embryo cells, and Rauscher murine leukemia virus-infected Fischer 344 rat embryo cells to chemical carcinogens. J Nat Cancer Inst 67 1303-1315. 

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