Syrian Hamster Embryo

Benzyl chloride also induced in vitro cellular transformation in Syrian hamster embryo cultures and DNA alkylation in several organs of the male mouse following iv adrninistration. In summary, lARC states there is limited evidence that benzyl chloride is carcinogenic in experimental animals epidemiological data was inadequate to evaluate carcinogenicity to humans (67). [Pg.61]

Syrian hamster embryo cells (clonal assay) Cell transformation No data — Amacher and Zelljadt 1983... [Pg.163]

Amacher DE, Zelljadt I. 1983. The morphological transformation of Syrian hamster embryo cells by chemicals reportedly nonmutagenic to Salmonella typhimurium. Carcinogenesis 4 291-295. [Pg.250]

Hayashi, N. Hasegawa, K. Barrett, J. C. Tsutsui, T. Estrogen-induced cell transformation and DNA adduct formation in cultured Syrian hamster embryo cells. Mol. Carcinog. 1996, 16, 149-156. [Pg.356]

Chinese hamster ovary cells Syrian hamster embryo cells Chromosomal aberration, DNA repair, mitotic disturbance NA + Bauchingerand Schmid 1972 Costa et al. 1982 Robison et al. 1984 Zelikoff et al. 1988 Ariza et al. 1998... [Pg.303]

Dunkel VC, Pienta RJ, Sivak A, et al. 1981. Comparative neoplastic transformation responses of Balb/3T-3 cells, Syrian hamster embryo cells, and Rauscher murine leukemia virus-infected Fischer 344 rat embryo cells to chemical carcinogens. J Nat Cancer Inst 67 1303-1315. [Pg.510]

Pienta RJ, Poiley JA, Lebherz WB III. 1977. Morphological transformation of early-passage golden Syrian hamster embryo cells derived from cryopreserved primary cultures as a reliable in vitro bioassay for identifying diverse carcinogens. Int J Cancer 19 642-655. [Pg.563]

Hepatocyte primary cultures Hepatocyte primary cultures Cell transformation Syrian hamster embryo cells... [Pg.62]

Sanner T, Rivedal E. 1985. Tests with the Syrian hamster embryo (SHE) cell transformation assay. In Ashby J, de Serres FJ, et al., eds. Progress in mutation research. Vol. 5. Evaluation of short-term tests for carcinogens. Amsterdam, The Netherlands Elsevier Science Publishers, 665-671. Sato M, Ishizu S, Momotuni H. 1975. [Determination of acrylonitrile, cyanide and thiocyanate in blood and urine.] Jap J Ind Health 17 99-105. (Japanese). [Pg.118]

Aniline transformed the Balb/3T3 mouse cell line at doses of 0.8 to 100 /dose-response effect), but not the Syrian hamster embryo cells (Dunkel et al. 1981). Results were negative in DNA damage assays in Escherichia coli (Mamber et al. 1983) and Bacillus subtilis (McCarroll et al. 1981). [Pg.50]

Lee, T.C., M. Oshimura, and J.C. Barrett. 1985. Comparison of arsenic-induced cell transformation, cytotoxicity, mutation and cytogenetic effects in Syrian hamster embryo cells in culture. Carcinogenesis 6 1421-1426. [Pg.1538]

On the other hand, mercuric chloride, at a concentration of 50 /iM, also has been shown to enhance viral transformation of Syrian hamster embryo cells [252],... [Pg.206]

Pienta RJ. 1980. Evaluation and relevance of the Syrian hamster embryo cell system. Applied Methods in Oncology 3 149-169. [Pg.278]

Tsutsui T, Hayashi N, Maizumi H, et al. 1997. Benzene-, catechol-, hydroquinone- and phenol-induced cell transformation, gene mutations, chromosome aberrations, aneuploidy, sister chromatid exchanges and unscheduled DNA synthesis in Syrian hamster embryo cells. Mutat Res 373 113-123. [Pg.229]

In Vitro Syrian Hamster Embryo Cell Transformation Test. 308... [Pg.305]

Isfort, R.J., Cody, D.B., Doerson, C., Kerckaert, G.A., and LeBoeuf, R.A., Alterations in cellular differentiation, mitogenesis, cytoskeleton and growth characteristics during Syrian hamster embryo cell multistep in vitro transformation, Int. J. Cancer, 59, 114, 1994. [Pg.313]

Engelhardt, G., Schwind, K.-R., and Mulller, B., The testing of chemicals in the Syrian hamster embryo (SHE) cell transformation assay for assessment of carcinogenic potential, Toxicology In Vitro, 8, 213, 2004. [Pg.313]

LeBoeuf, R.A., and Kerckaert, G., Enhanced morphological transformation of early passage Syrian hamster embryo cells cultured in medium with a reduced bicarbonate concentration and pH, Carcinogenesis, 8, 680, 1987. [Pg.313]

Syrian hamster embryo cells Enhanced transformation by SA7 adenovi res No data - Hatch et al. 1983... [Pg.48]

Hatch GG, Mamay PD, Ayer ML, et al. 1983. Chemical enhancement of viral transformation in Syrian hamster embryo cells by gaseous and volatile chlorinated methanes and ethanes. Cancer Res 43 1945-1950. [Pg.98]

Cultured cells (from human peripheral blood lymphocytes or from Syrian hamster embryo (SHE)) or cell lines (CHO, V79, CHL/IU, L5178 Y) are exposed to the test substances both with and without an exogenous source of metabolic activation unless primary cells with metabolizing capability are used. After exposure to the test substance, cell cultures are grown for a sufficient period to... [Pg.156]

Custer L, Gibson DP, Aardema MJ, Le Boeuf RA. A refined protocol for conducting the low pH 6.7 Syrian hamster embryo (SHE) cell transformation assay. Mutat Res 2000 455 129-39. [Pg.142]

Farmer P Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment ILSl/HESl research programme on alternative cancer models results of Syrian hamster embryo cell transformation assay. International Life Sciences Institute/Health and Environmental Science Institute. Toxicol Pathol 2002 30 536-8. [Pg.142]

Acetamide was mutagenic in Escherichia coli and Salmonella typhimurium-, this effect was independent of dose. Acetamide produced morphological transformation in Syrian hamster embryo cells in the absence of metabolic activation. However, acetamide did not induce reversions in several Salmonella typhimurium strains. ... [Pg.14]

Amitrole was not genotoxic in bacterial assays and cultured mammalian cells or in rodents exposed in vivo it did induce transformation of Syrian hamster embryo cells in vitro)... [Pg.44]

Schiffmann D, Reichert D, Henschler D. 1984. Induction of morphological transformation and unscheduled DNA synthesis in Syrian hamster embryo fibroblasts by hexachlorobutadiene and its putative metabolite pentachlorobutenoic acid. Cancer Lett 23 297-305. [Pg.111]

Mieronueleus formation, Syrian hamster embryo eells, in vitro Chromosomal aberrations, Chinese hamster Don eells in vitro Chromosomal aberrations, Chinese hamster lung eells in vitro... [Pg.107]

Chromosomal aberrations, rat liver RL4 eells in vitro Chromosomal aberrations, Syrian hamster embryo eells in vitro Aneuploidy, Chinese hamster liver eells in vitro Mitotie aberrations, Chinese hamster primary liver eells in vitro Aneuploidy, rat liver RL4 eells in vitro Cell transformation, BALB/3T3 mouse eells Cell transformation, BALB/3T3 mouse eells Cell transformation, C3H10T14 mouse eells... [Pg.108]

Cell transformation, RLV/Fiseher rat Cell transformation, SA7/Syrian hamster embryo eells Cell transformation, Syrian hamster embryo eells Unseheduled DNA synthesis, human hepatoeytes in vitro Gene mutation, human lymphoeytes, TK and HPRT loei in vitro Sister ehromatid exehange, human lymphoeytes in vitro Sister ehromatid exehange, human lymphoeytes (metabolie aetivation by eo-eultured with rat liver eells) in vitro Chromosomal aberrations, human lymphoeytes in vitro... [Pg.108]

Mieronueleus formation, B6C3F i mouse erythroeytes in vivo Chromosomal aberrations, Fiseher 344 rat bone marrow in vivo Chromosomal aberrations, Syrian hamster embryos in vivo Dominant lethal test, ICR Swiss miee in vivo Dominant lethal test, miee in vivo [strain not speeified] Dominant lethal test, ICR Swiss miee in vivo Aneuploidy, Fiseher 344 rat hepatoeytes in vivo... [Pg.110]

Cell transformation, Syrian hamster embryos in vivo/in vitro Binding (eovalent) to Fiseher 344 rat hepatoeyte DNA in vitro Binding (eovalent) to Fiseher 344 rat liver DNA in vivo... [Pg.110]

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