Hamster Syrian

Benzyl chloride also induced in vitro cellular transformation in Syrian hamster embryo cultures and DNA alkylation in several organs of the male mouse following iv adrninistration. In summary, lARC states there is limited evidence that benzyl chloride is carcinogenic in experimental animals epidemiological data was inadequate to evaluate carcinogenicity to humans (67). 

Dzwonkowska A, Hubner H. 1986. Induction of chromosomal aberrations in the Syrian hamster by insecticides tested in vivo. Arch Toxicol 58 152-156. 

Syrian hamster embryo cells (clonal assay) Cell transformation No data — Amacher and Zelljadt 1983... 

Amacher DE, Zelljadt I. 1983. The morphological transformation of Syrian hamster embryo cells by chemicals reportedly nonmutagenic to Salmonella typhimurium. Carcinogenesis 4 291-295. 

Including In Syrian hamsters the pancreas, which has not been susceptible In rats to nitrosamlne carcinogenesis. 

Roy, D, Floyd, R.A. and Liehr, J.G. (1991). Elevated 8-hydroxy-deoxy anosine levels in DNA of diethylstilbcstrol-treated Syrian hamsters covalent DNA damage by free radicals generated by redox cycling of diethyl-stilbestrol. Cancer Res. 51, 3882-3885. 

Fischer R. and Brown P. (1993). Vaginal secretions increase the likelihood of inter-male aggression in Syrian hamsters. Physiol Behav 54, 213-214. 

Kollack-Walker S. and Newman S.W. (1997). Mating-induced expression of c-fos in the male Syrian hamster brain role of experience, pheromones, and ejaculations. Neurobiol J 32, 481-501. 

Wood R.I. (1998). Integration of chemosensory and hormonal input in the male Syrian hamster brain. Proc Natl Acad Sci 855, 362-372. 

Hayashi, N. Hasegawa, K. Barrett, J. C. Tsutsui, T. Estrogen-induced cell transformation and DNA adduct formation in cultured Syrian hamster embryo cells. Mol. Carcinog. 1996, 16, 149-156. 

Mewhinney JA, Hobbs CH, Mo T. 1976b. Toxicity of inhaled polydisperse or monodisperse aerosols of 241Am02 in Syrian hamsters III. In Boecker BB, Jones RK, Barnett NJ, eds. Inhalation toxicology research institute annual report Lovelace Biomedical and Environmental Research Institute. 

Seidel A. 1977. The deposition of241 Am and 252Cf in the skeleton of Chinese hamster, Syrian hamster and the rat. Health Phys 33 83-86. 

Seidel A, Wiener M, Kruger E, et al. 1986. Studies on the lysosomal binding of 141Ce, 239Np, 239Pu and 241 Am in rat and Syrian hamster liver using carrier-free electrophoresis. Int J Rad Appl Instrum B13(5) 515-518. 

Chinese hamster ovary cells Syrian hamster embryo cells Chromosomal aberration, DNA repair, mitotic disturbance NA + Bauchingerand Schmid 1972 Costa et al. 1982 Robison et al. 1984 Zelikoff et al. 1988 Ariza et al. 1998... 

Dunkel VC, Pienta RJ, Sivak A, et al. 1981. Comparative neoplastic transformation responses of Balb/3T-3 cells, Syrian hamster embryo cells, and Rauscher murine leukemia virus-infected Fischer 344 rat embryo cells to chemical carcinogens. J Nat Cancer Inst 67 1303-1315. 

Pienta RJ, Poiley JA, Lebherz WB III. 1977. Morphological transformation of early-passage golden Syrian hamster embryo cells derived from cryopreserved primary cultures as a reliable in vitro bioassay for identifying diverse carcinogens. Int J Cancer 19 642-655. 

Golombek, D. A Cardinali, D. P. (1993). Melatonin accelerates re-entrainment after phase advance of the light-dark cycle in Syrian hamsters. Antagonism by flumazenil. Chronobiol. Int. 10, 435-41. 

Haley, A.J. (1966) Biology of the rat nematode Nippostrongylus brasiliensis (Travassos, 1914). IV. Characteristics of N. brasiliensis after 1 to 40 serial passages in the Syrian hamster. Journal of Parasitology 52,109—116. 

Class D substances and with a 10 h half-time for Class W and Class Y substances. Absorption of material directly into blood is predicted to occur with a 15 min half-time for all compounds. Direct absorption is predicted for 0.5 of the Class D material, for 0.1 of the Class W material, and for 0.01 of the Class Y material. Cuddihy and Ozog (1973) studied direct absorption of 144CeCl3 solutions deposited in the nasal region of Syrian hamsters. About 0.04 of the deposited radiocerium was absorbed through the nasal membranes into the blood. This is about one-half of that predicted by the Task Group Model for nasal absorption of Class W compounds in humans. 

There are also significant species differences in respiratory tract deposition and clearance of inhaled particles (Thomas, 1972). Data from a number of studies are summarized in Table 14 to assist in evaluating the several factors that influence the retention of inhaled materials. In studies with rats, Syrian hamsters, Chinese hamsters, and mice, the l44Ce was generally lost at a more rapid rate from the pulmonary region than was noted for the dog. A major factor in this difference may be differences in initial deposition sites and perhaps... 

Syrian hamster inhalation CeOa, 860°C AMAD 1-2 p 26 d 84 d 340 d 7 7 5 life span (in progress) radiation pneumonitis, pulmonary fibrosis No No No Hobbs et al. (1975)... 

Cuddihy, R. G. and Ozog, J. A. (1973). Nasal absorption of CsCL, BaCl2, and CeCL, in Syrian hamsters, Health Phys. 25, 219. 

Hobbs, C. H., Benjamin, S. A. and McClellan, R. 0. (1975). Toxicity of inhaled 144Ce O2 in immature, young adult, and aged Syrian hamsters. Ill, page 178 in Inhalation Toxicology Research Institute Annual Report 1974-1975, Report No. LF-52 (Lovelace Foundation, Albuquerque, New Mexico). 

Hepatocyte primary cultures Hepatocyte primary cultures Cell transformation Syrian hamster embryo cells... 

Sanner T, Rivedal E. 1985. Tests with the Syrian hamster embryo (SHE) cell transformation assay. In Ashby J, de Serres FJ, et al., eds. Progress in mutation research. Vol. 5. Evaluation of short-term tests for carcinogens. Amsterdam, The Netherlands Elsevier Science Publishers, 665-671. Sato M, Ishizu S, Momotuni H. 1975. [Determination of acrylonitrile, cyanide and thiocyanate in blood and urine.] Jap J Ind Health 17 99-105. (Japanese). 

Monte Carlo/simulated annealing (MC/SA) algorithm for sequential assignment in uniformly 13C, 15N-labeled proteins [137]. The two-dimensional (2D) NCACX and NCOCX spectra measured for the fibril samples of full-length Syrian hamster prion protein (residues 23-231) have been analyzed by the MC/SA protocol, from which it has been concluded that the fibril core is formed primarily in the region of residues 173-224 [54]. 

Aniline transformed the Balb/3T3 mouse cell line at doses of 0.8 to 100 /dose-response effect), but not the Syrian hamster embryo cells (Dunkel et al. 1981). Results were negative in DNA damage assays in Escherichia coli (Mamber et al. 1983) and Bacillus subtilis (McCarroll et al. 1981). 

MacEwen, J.D., and E.H.Vemot. 1975. Acute inhalation toxicity of hydrazine, monomethylhydrazine and unsymmetrical dimethylhydrazine in golden Syrian hamsters. Toxic Hazards Research Unit Annual Report. AMRL-TR-75-57. Aerospace Medical Research Laboratory, Wright-Patterson AFB, OH. 

Olson, J.R., M.A. Holscher, and R.A. Neal. 1980a. Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the golden Syrian hamster. Toxicol. Appl. Pharmacol. 55 67-78. 

Lee, T.C., M. Oshimura, and J.C. Barrett. 1985. Comparison of arsenic-induced cell transformation, cytotoxicity, mutation and cytogenetic effects in Syrian hamster embryo cells in culture. Carcinogenesis 6 1421-1426. 

Syrian hamster, Cricetus sp. 0.12-2 Gy, single acute exposure Human, Homo sapiens Genes modifying cytoskeletal development adversely affected at all doses within 3 h by both high LET (neutrons) and low LET (gamma rays, X-rays) radiations 11... 

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