Rauscher murine leukemia virus

Dunkel VC, Pienta RJ, Sivak A, et al. 1981. Comparative neoplastic transformation responses of Balb/3T-3 cells, Syrian hamster embryo cells, and Rauscher murine leukemia virus-infected Fischer 344 rat embryo cells to chemical carcinogens. J Nat Cancer Inst 67 1303-1315. 

AntivertigO effect. Powdered rhizome, administered orally to human adults at a dose of 1 g/person, was active vs seasickness ° k Rhizome, administered orally to adults of both sexes at a dose of 1 g/person, was inactive. The treatment was administered 2 hours before the subjects were rotated in a chair making head movement until a symptom short of vomiting was reached ° Antiviral activity. Aqueous low-speed supernatant of the rhizome, at a concentration of 1% and the rhizome juice, produced strong activity on virus-top necrosis h Decoction of the rhizome together with c at a concentration of 250 pg/mL, was active on HlV-1 and Rauscher murine leukemia viruses. Reverse transcriptase activity was inhibited . Water extract of the rhizome, in cell culture at a concentration of 10%, was inactive on herpes virus type 2, A2-... 

Reverse transcriptase inhibition. Decoction of the rhizome, in cell culture, was active on Rauscher murine leukemia virus. The study was conducted with a prescription consisted of Bupleurum falcatum (Rt), Scutellaria baicalensis (Rt), Pinellia ternata (Tu), Zizyphus jujuba (Fr), Panax ginseng (Rt), and Glycyrrhiza glabra (Rh) h Serotonin antagonist activity. Acetone extract of the rhizome, at a concentration of 25 pg/mL, was active on the guinea pig ileum vs serotonin-induced contract-ions ° . 

Raman spectroscopy, 67 Rauscher murine leukemia virus, electron spin resonance (ESR) and, 51... 

Castanospermine has been screened for efficacy against simian immunodeficiency virus (265), and has been shown to prevent syncytium formation in feline astrocyte cultures infected with the feline immimodeficiency virus by modifying the viral cell envelope (266). It suppressed syncytium formation and hemolytic activity in baby hamster kidney cells infected with Newcastle disease virus however, synthesis and cell surface expression of the hemagglutinin-neuraminidase glycoprotein in the viral envelope were not affected, which strengthens the hypothesis that poor transport of the parent alkaloid across membrane barriers may limit its therapeutic use (267). Both 239 and its 6-0-butanoyl ester had comparable relative toxicities and antiviral effects on Rauscher murine leukemia virus (268), but the ester was more potent than the parent alkaloid in inhibiting replication of Moloney murine leukemia virus (258). The ester was also active against herpes simplex viruses types 1 and 2 (269,270). In the latter case, conclusive evidence was provided for intracellular hydrolysis to 239. 

McKissick, G.E., R.A. Griesemer, and R.L. Farrell. 1970. Aerosol transmission of Rauscher murine leukemia virus. J. Nat. Cancer Inst. 45 625-636. 

Several 2,5 -anhydro analogues of 3 -azido-2, 3 -dideoxyuridine (1, AZDU), 3 -azido-3 -deoxythymidine (2, AZT), 3 -azido-5-bromo-2, 3 -dideoxyuridine (5), 3 -azido-2, 3 -dideoxy-5-iodouridine (6), and the 3 -azido derivative of 2 -deoxy-5-methylisocytidine, compounds 38-42, have been synthesized and evaluated against human immunodeficiency virus (HIV-1) and Rauscher-murine leukemia virus (R-MuLV). in general, the parent compounds 1,2,5, and 6 were approximately 1.8 to 6 times more active against HIV-1 than their corresponding 2,5 -anhydro derivatives (compounds 38-41, Table 3). Compounds 38-41 have significant antiviral activity with respective EC50 values of 4.95,0.56, 28, and 27.1 pM. 3 -Azido-2, 3 -dideoxy-5-methylisocytidine (42) also demonstrated anti-HIV-1... 

Synthesis and antiviral activity of several 2,5 -anhydro analogues of 3 -azido-3 -deoxythymidine, 3 -azido-2 ,3 -dideoxyuridine, 3 -azido-2 ,3 -dideoxy-5-halouridines, and 3 -deoxythymidine against human immunodeficiency virus and Rauscher-murine leukemia virus, J. Med. Chem. 32 1891 (1989). 

Many of the rifaldehyde derivatives have also been screened for inhibition of the RNA-directed DNA polymerases (reverse transcriptases) of murine sarcoma virus (MSV) and Rauscher murine leukemia virus (RLV) and the purified DNA polymerases from human normal and leukemic lymphoblasts (40,163). Surprisingly perhaps, the best compounds shown in Fig. 19 (48, 49, rifampicin) were inactive. Further testing of derivatives of rifaldehyde indicated tl at a longer, bulkier side chain is needed at C-25 for inhibition of viral polymerases. 

Yang, S. S., F. M. Herrera, R. G. Smith, M. S. Reitz, G. Lancini, R. Ting, and R. C. Gallo Rifamycin Antibiotics Inhibitors of Rauscher Murine Leukemia Virus Reverse Transcriptase and of Purified DNA Polymerases from Human Normal and Leukemic Lymphoblasts. J. Nat. Cancer Inst. 49, 7 (1972). 

Total syntheses of chrysin (93) and luteolin (94), which are non-toxic potent inhibitors of reverse transcriptases from Rauscher murine leukemia (RLV) and the human immunodeficiency virus (HIV), were accomplished by Antus and coworkers via cyclodehydrogenation of the appropriately substituted 2 -hydroxy-chalcone (179) in the presence of PIDA/KOH in MeOH [136] (Scheme 45). 

Finally, due to the above conqretitive mechanism, quercetin, quercetagetin, m)uicetin, and especially baicalein were potent inhibitors of murine leukemia virus (MLV) (Rauscher and Moloney strains) and HTV-l reverse transcriptases (Ono et al. 1989). Comparative studies with other flavonoids (hydroxyflavones, dihydroxyflavones and polyhydroxyflavones, and flavanones) revealed that the presence of both the unsaturated double bond between po-... 

PMEA and its congeners are more effective in vivo than could be predicted from their in vitro potency. While less potent as an antiretrovirus agent than AZT in vitro, PMEA proved clearly superior to AZT when the two drugs were compared for their effectiveness in vivo, in mice infected with murine Moloney sarcoma virus [51,52]. PMEA was also shown to be effective against various other retrovirus infections, including Friend leukemia virus (FLV), Rauscher leukemia virus (RLV), and LP-BM5 (murine AIDS) virus infection in mice, feline leukemia virus (FeLV) or feline immunodeficiency virus (FIV) infection in cats, and SIV infection in macaque (rhesus) monkeys (for review, see Ref. 53). In the latter model [54], again PMEA proved far superior to AZT in suppressing several parameters of the disease. 

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