Related proteins

Biosynthesis. CRE is derived from a precursor of 196 amino acids (84,85). This gene contains one copy of CRE, which is flanked by double basic amino acids. The amino acid sequence of the CRE precursor suggests that it may arise from proteins related to POMC and neurophysins (31). The CRE precursor contains a cAMP responsive element which aHows stimulation of mRNA synthesis when intraceHular levels of cAMP are increased (86). 

La, T.N.B. Latchman, D.S. (1988). A cellular protein related to heat shock protein 90 accumulates during herpes simplex virus infection and is overexpressed in transformed cells. Exp. Cell Res. 178, 169-179. 

Structural transitions in the protein related to energy transformation and Na,K-transport... 

The author gratefully acknowledges the cooperation of Dr. Roger Cooke, the Department of Biochemistry and Biophysics, U.C.S.F., for contractile protein-related materials and assays. 

Singer A.G., Clancy A.N. and Macrides F. (1989). Conspecific and heterospecific proteins related to aphrodisin lack aphrodisiac activity in male hamsters. Chem Senses 14, 563-576. 

Gq and Gn are two closely related and widely distributed G-proteins whose a subunits stimulate PLC. They are not ADP-ribosylated by either PTx or CTx, so they are probably responsible for many instances of PTx-insensitive PLC stimulation. G14 and G15 are two more distantly related PTx-insensitive G-proteins that can stimulate PLC. G12 and G13 are other PTx-insensitive G-proteins related to Gq, while Gz is more closely related to G, the precise functions of these G-proteins are not yet clear. Though of restricted distribution (to hemopoietic-derived cells), G16 is interesting because it lacks receptor specificity and so acts as a universal PLC transducer. 

Hu B, Trinh K, Figueira WF, Price PA 1996 Isolation and sequence of a novel human chondrocyte protein related to mammalian members of the chitinase protein family. J Biol Chem 271 19415-19420... 

Shepard, I. L. Jenkins, D. C. Duckworth, J. R. Sportsman et al. Association of intestinal peptide transport with a protein related to the cadherin superfamily, Science 1994, 264, 430-433... 

Homo sapiens (compared to Drosophila melanogaster) Large-scale gene duplications with substantial expansion of genes involved in acquired immune response (B cells, T cells, major histocompatibility complex genes, cytokines, chemokines and their receptors), plasma proteases (complement and hemostatic proteins), proteins associated with apoptotic regulation and proteins related to neuronal network formation and electrical coupling... 

Evenepoel P, Claus D, Geypens B, Maes B, Hiele M, Rutgeerts P, et al Evidence for impaired assimilation and increased colonic fermentation of protein, related to gastric acid suppression therapy. Aliment Pharmacol Ther 1998 12 1011-1019. 

Drescher, U., Kremoser, C., Handwerker, C. et al. In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases. Cell 82 359-370,1995. 

The term "structural genomics" is used to describe how the primary sequence of amino acids in a protein relates to the function of that protein. Currently, the core of structural genomics is protein structure determination, primarily by X-ray crystallography, and the design of computer programs to predict protein fold structures for new proteins based on their amino acid sequences and structural principles derived from those proteins whose 3-dimensional structures have been determined. Plant natural product pathways are a unique source of information for the structural biologist in view of the almost endless catalytic diversity encountered in the various pathway enzymes, but based on a finite number of reaction types. Plants are combinatorial chemists par excellence, and understanding the principles that relate enzyme structure to function will open up unlimited possibilities for the... 

Of particular interest is the comparison of the performance of cation exchange and mixed mode sorbents for their efficacy in cleaning up endogenous phospholipids. Unlike the protein-related materials that are eluted in the very early stages of HPLC, these phospholipids elute in the hydro-phobic region and interfere with drug peaks which also elute around the same time. 

Table V shows a classification of binary relations gene-gene relations, protein-protein relations, and other molecule-molecule relations. Different sets of binary relations can then be related to different types of graphs. For example, the generalized protein-protein interaction network is equivalent to a set of protein-protein binary relations. The KEGG metabolic pathway is a generalized protein-protein network, but it is also a network of chemical compounds that can be converted to a set of com-...

Protein-protein relation Sequence similarity/orthology Enzyme-enzyme relation by successive reactions Transcription factor-transcribed gene product relation Direct protein-protein interaction... 

Rothe, M., et al.. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell,... 

AriNT A novel UBA-like domain is found in certain RING-finger type proteins related to the ariadne protein of the fruit fly. Here, the AriNT domain is invariably... 

Cullis PR, Chonn A, Semple SC. Interactions of liposomes and lipid-based carrier systems with blood proteins Relation to clearance behaviour in vivo. Adv Drug Deliv Rev 1998 32 3. 

The crystal structure of the peptide substrate-binding domain (140—245 of 517 residues of human al subunit) of the human type I enzyme forms 2.5 tetratricopeptide (TPR) repeat domains with five a helices (PDB accession number ITJC). The organization of tyrosine residues is suggested to be key to its interaction with the substrate peptide in a polyproline II helix. The TPR motif is composed of a 34 amino acid repeated a helical motif, and is typically involved in protein-protein interactions. The tandem repeats of TPR motifs are found in many proteins related to chaperone, cell cycle, transcription, and protein transport... 

Since the discovery of ubiquitin as a polypeptide modifier of substrate proteins, several other proteins related to ubiquitin have been discovered (Table 3). Some of the proteins such as small ubiquitin-related modifier (SUMO) and Rubl are conjugated to substrate proteins in a manner similar to conjugation of ubiquitin. It is not clear whether this process is generally applicable to all UbL proteins. SUMO and Rubl have been investigated in some detail and the findings are described below. 

Legouis, R., HardeUn, J. P., LeviUiers, J., et al. (1991) The candidate gene for the X-linked Kallmann syndrome encodes a protein related to adhesion molecules. Cell. 67, 423 35. 

Andersen, O.M., Reiche, J., Schmidt, V., et al. (2005) Neuronal sorting protein-related receptor sorLA/LRl 1 regulates processing of the amyloid precursor protein. Proc. Natl. Acad. Sci. U. S.A., 102, 13461-13466. 

Immunoglobulin. Immunoprotein glycoprotein of animal origin with known antibody activity, or protein related by chemical structure, which may or may not have antibody activity. Divided into five classes IgM, IgG, IgA, IgD, and IgE on the basis of structure and biological activity. Immunostimulant. Stimulating various functions or activities of the immune system. Immunosuppressant. An agent capable of suppressing immune responses. 

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