Adipocyte differentiation related protein

ADPH was not identified as a major MFGM protein until recently because it co-migrates with the glycoprotein known as PAS 6/7. ADPH was known previously as adipocyte differentiation-related protein (ADRP) because it is expressed early during adipocyte differentiation and was believed to be expressed only in adipocytes (Jiang and Serrero, 1992). Since then, ADPH has been detected in a large number of tissues and cell types, where it invariably is associated with intracellular lipid droplets (Heid et al., 1996 1998 Brasaemle et al., 1997). 

Heid, H.W., Schnolzer, M., Keenan, T.W. 1996. Adipocyte differentiation-related protein is secreted into milk as a constituent of milk lipid globule membrane. Biochem. J. 320, 1025-1030. 

Perilipins Little is known about proteins on the surface of mammalian intracellular LD. Two groups of proteins whose association with LD in animal cells is well documented are the perilipins and adipocyte differentiation related protein (ADRP) (reviewed in Ref. [156]). The human ortholog of ADRP has been termed adipophilon [157]. Other proteins at or near the surface of the LD of adipocytes include the capsular proteins [158-160] and vimentin [153, 161]. Furthermore, certain enzymes, e.g. eicosanoid-forming enzymes, associate with LD in various types of cells [162-164]. 

D. Marchesan, M. Rutberg, L. Anders-SON, L. Asp, T. Larsson, J. Boren, B.R. Johansson, and S.-O. Oloesson, A phospholipase D-dependent process forms lipid droplets containing caveolin, adipocyte differentiation-related protein (ADRP), and vimentin in a cell-free system, J. 

Keenan, Adipocyte differentiation-related protein is secreted into milk as a constituent of milk lipid globule membrane,... 

J. Gao, H. Ye, and G. Serrero, Stimulation of adipose differentiation related protein (ADRP) expression in adipocyte precursors by long-chain fatty acids, J. 

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