PS-specific receptor

Gq protein-coupled phosphatidylinositol-Ca " " pathway. The binding of a hormone at a specific receptor site results in the activation of G-protein which, in turn, activates phospholipase C via Gga-OTP-protein. The action of phospholipase C on phosphatidylinositol 4,5-bisphosphate (PIP2) yields inositol trisphosphate (IP3) and diacylglycerol (DAG) which, along with phosphatidylserine (PS), activates protein kinase C. IP3 binds to receptors on SER, releasing Ca " which, in turn, activates another set of protein kinases. -I-, Activation. 

With regard to transport capacity, the introduction of the anti-human insulin receptor antibody (HIR MAb) 83-14 as a vector indicates the potential for future improvements in brain-specific delivery vectors. Compared to anti-TfR monoclonal antibodies, the brain de-hvery in primates is over 7-fold higher due to the high PS product of the HIR MAb. 

Del Rio B, Pedrero JMG, Martinez-Gampa G, ZuazuaP, Lazo PS, Ramos S, Melatonin, an endogenous-specific inhibitor of estrogen receptor a via calmodidin, J Biol Chem 279 38294-38302, 2004. 

Bergson C, Mrzljak L, Lidow MS, Goldman-Rakic PS M, Levenson R (1995a) Characterisation of subtype-specific antibodies to the human D5 dopamine receptor studies in primate brain and transfected mammalian cells. Proc Natl Acad USA 92 3468-3472. 

The involvement of specific residues in the determination of conductance properties of the protein is readily addressed by use of the synthetic proteins. Accordingly, a tethered tetramer of M2 8 segments in which serine-8 is replaced with alanine was synthesized. This analog, T4M28(S - A), also forms channels in PC membranes with a single-channel conductance in symmetric 0.5-M KCl of 20 pS (49), lower than the 24 pS observed with T4M28. These results are in accord with observations obtained with site-directed mutagenesis of rodent acetylcholine receptors (72). 

Quiocho FA, Ledvina PS. Atomic structure and specificity of bacteriai peripiasmic receptors for active transport and chemotaxis variation of common themes. Moi Microbioi 1996 20 17-25. 

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